| nr |
titel |
auteur |
tijdschrift |
jaar |
jaarg. |
afl. |
pagina('s) |
type |
| 1 |
A combination of 19F NMR and surface plasmon resonance for site-specific hit selection and validation of fragment molecules that bind to the ATP-binding site of a kinase
|
Nagatoishi, Satoru
|
|
|
26 |
8 |
p. 1929-1938
|
artikel
|
| 2 |
Adenosine analogs bearing phosphate isosteres as human MDO1 ligands
|
Zhang, Yuezhou
|
|
|
26 |
8 |
p. 1588-1597
|
artikel
|
| 3 |
A novel series of 4-methyl substituted pyrazole derivatives as potent glucagon receptor antagonists: Design, synthesis and evaluation of biological activities
|
Shu, Shuangjie
|
|
|
26 |
8 |
p. 1896-1908
|
artikel
|
| 4 |
Aralkyl selenoglycosides and related selenosugars in acetylated form activate protein phosphatase-1 and -2A
|
Kónya, Zoltán
|
|
|
26 |
8 |
p. 1875-1884
|
artikel
|
| 5 |
A Rhodamine B-based fluorescent probe for imaging Cu2+ in maize roots
|
Lv, Ting
|
|
|
26 |
8 |
p. 1448-1452
|
artikel
|
| 6 |
2-Arylthio-5-iodo pyrimidine derivatives as non-nucleoside HBV polymerase inhibitors
|
Wang, Jie
|
|
|
26 |
8 |
p. 1573-1578
|
artikel
|
| 7 |
Borrelidins F–I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89
|
Sun, Jianbin
|
|
|
26 |
8 |
p. 1488-1494
|
artikel
|
| 8 |
Design and synthesis of 1-(1-benzothiophen-7-yl)-1H-pyrazole, a novel series of G protein-coupled receptor 52 (GPR52) agonists
|
Nakahata, Takashi
|
|
|
26 |
8 |
p. 1598-1608
|
artikel
|
| 9 |
Design and synthesis of estrogen receptor ligands with a 4-heterocycle-4-phenylheptane skeleton
|
Eto, Ryo
|
|
|
26 |
8 |
p. 1638-1642
|
artikel
|
| 10 |
Design, synthesis and biological assessment of N-adamantyl, substituted adamantyl and noradamantyl phthalimidines for nitrite, TNF-α and angiogenesis inhibitory activities
|
Luo, Weiming
|
|
|
26 |
8 |
p. 1547-1559
|
artikel
|
| 11 |
Design, synthesis and biological evaluation of anti-pancreatic cancer activity of plinabulin derivatives based on the co-crystal structure
|
Fu, Zhangyu
|
|
|
26 |
8 |
p. 2061-2072
|
artikel
|
| 12 |
Design, synthesis and biological evaluation of novel 7-azaspiro[3.5]nonane derivatives as GPR119 agonists
|
Matsuda, Daisuke
|
|
|
26 |
8 |
p. 1832-1847
|
artikel
|
| 13 |
Design, synthesis and biological evaluation of novel hydroxamic acid based histone deacetylase 6 selective inhibitors bearing phenylpyrazol scaffold as surface recognition motif
|
Yang, Jinyu
|
|
|
26 |
8 |
p. 1418-1425
|
artikel
|
| 14 |
Design, synthesis and biological evaluation of novel 3-substituted pyrazolopyrimidine derivatives as potent Bruton’s tyrosine kinase (BTK) inhibitors
|
Zheng, Nan
|
|
|
26 |
8 |
p. 2165-2172
|
artikel
|
| 15 |
Design, synthesis, and evaluation of the antiproliferative activity of hydantoin-derived antiandrogen-genistein conjugates
|
George, Alex
|
|
|
26 |
8 |
p. 1481-1487
|
artikel
|
| 16 |
Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno[3′,2′:3,4]pyrido[1,2-b]isoquinoline and 5,8,12,12a-tetrahydro-6H-thieno[2′,3′:4,5]pyrido[2,1-a]isoquinoline derivatives as cellular activators of adenosine 5′-monophosphate-activated protein kinase (AMPK)
|
Gu, Zhanni
|
|
|
26 |
8 |
p. 2017-2027
|
artikel
|
| 17 |
Development of a microbioreactor for glycoconjugate synthesis
|
Haneda, Katsuji
|
|
|
26 |
8 |
p. 2092-2098
|
artikel
|
| 18 |
Development of benzoxazole deoxybenzoin oxime and acyloxylamine derivatives targeting innate immune sensors and xanthine oxidase for treatment of gout
|
Huang, Jun
|
|
|
26 |
8 |
p. 1653-1664
|
artikel
|
| 19 |
Development of selective inhibitors for the treatment of rheumatoid arthritis: (R)-3-(3-(Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)-3-oxopropanenitrile as a JAK1-selective inhibitor
|
Chough, Chieyeon
|
|
|
26 |
8 |
p. 1495-1510
|
artikel
|
| 20 |
2,4-Diamino-8-quinazoline carboxamides as novel, potent inhibitors of the NAD hydrolyzing enzyme CD38: Exploration of the 2-position structure-activity relationships
|
Deaton, David N.
|
|
|
26 |
8 |
p. 2107-2150
|
artikel
|
| 21 |
Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors
|
Rohde, Jason M.
|
|
|
26 |
8 |
p. 1727-1739
|
artikel
|
| 22 |
Discovery and optimization of tetrahydropyrido[4,3-d]pyrimidine derivatives as novel ATX and EGFR dual inhibitors
|
Jing, Tongfei
|
|
|
26 |
8 |
p. 1784-1796
|
artikel
|
| 23 |
Discovery of DSP-1053, a novel benzylpiperidine derivative with potent serotonin transporter inhibitory activity and partial 5-HT1A receptor agonistic activity
|
Yoshinaga, Hidefumi
|
|
|
26 |
8 |
p. 1614-1627
|
artikel
|
| 24 |
Discovery of 18β-glycyrrhetinic acid conjugated aminobenzothiazole derivatives as Hsp90-Cdc37 interaction disruptors that inhibit cell migration and reverse drug resistance
|
Jin, Le
|
|
|
26 |
8 |
p. 1759-1775
|
artikel
|
| 25 |
Discovery of isatin and 1H-indazol-3-ol derivatives as d-amino acid oxidase (DAAO) inhibitors
|
Szilágyi, Bence
|
|
|
26 |
8 |
p. 1579-1587
|
artikel
|
| 26 |
Discovery of novel 4-aryl-thieno[1,4]diazepin-2-one derivatives targeting multiple protein kinases as anticancer agents
|
Lee, Junghun
|
|
|
26 |
8 |
p. 1628-1637
|
artikel
|
| 27 |
Discovery of potent DOT1L inhibitors by AlphaLISA based High Throughput Screening assay
|
Song, Yakai
|
|
|
26 |
8 |
p. 1751-1758
|
artikel
|
| 28 |
Discovery of selective EGFR modulator to inhibit L858R/T790M double mutants bearing a N-9-Diphenyl-9H-purin-2-amine scaffold
|
Hu, Jinxing
|
|
|
26 |
8 |
p. 1810-1822
|
artikel
|
| 29 |
Editorial Board
|
|
|
|
26 |
8 |
p. ii
|
artikel
|
| 30 |
Enhancing the anti-biofilm activity of 5-aryl-2-aminoimidazoles through nature inspired dimerisation
|
Trang, Tran Thi Thu
|
|
|
26 |
8 |
p. 1470-1480
|
artikel
|
| 31 |
Fine-tuning the physicochemical properties of peptide-based blood–brain barrier shuttles
|
Ghasemy, Somaye
|
|
|
26 |
8 |
p. 2099-2106
|
artikel
|
| 32 |
Fluorine-18 labeling of an anti-HER2 VHH using a residualizing prosthetic group via a strain-promoted click reaction: Chemistry and preliminary evaluation
|
Zhou, Zhengyuan
|
|
|
26 |
8 |
p. 1939-1949
|
artikel
|
| 33 |
Graphical abstract TOC
|
|
|
|
26 |
8 |
p. IBC
|
artikel
|
| 34 |
Graphical abstract TOC
|
|
|
|
26 |
8 |
p. OBC
|
artikel
|
| 35 |
Graphical abstract TOC continued
|
|
|
|
26 |
8 |
p. IV-XX
|
artikel
|
| 36 |
High expression of integrin αvβ3 enables uptake of targeted fluorescent probes into ovarian cancer cells and tumors
|
Shaw, Scott K.
|
|
|
26 |
8 |
p. 2085-2091
|
artikel
|
| 37 |
Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion
|
Wilke, Julian
|
|
|
26 |
8 |
p. 1453-1461
|
artikel
|
| 38 |
Identification of novel PDEδ interacting proteins
|
Küchler, Philipp
|
|
|
26 |
8 |
p. 1426-1434
|
artikel
|
| 39 |
In silico studies, synthesis and pharmacological evaluation to explore multi-targeted approach for imidazole analogues as potential cholinesterase inhibitors with neuroprotective role for Alzheimer’s disease
|
Gurjar, Archana S.
|
|
|
26 |
8 |
p. 1511-1522
|
artikel
|
| 40 |
Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer’s disease
|
Lu, Xin
|
|
|
26 |
8 |
p. 1665-1674
|
artikel
|
| 41 |
Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine
|
Hanaki, Mizuho
|
|
|
26 |
8 |
p. 1538-1546
|
artikel
|
| 42 |
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer’s disease
|
Xu, Rui
|
|
|
26 |
8 |
p. 1885-1895
|
artikel
|
| 43 |
New histone demethylase LSD1 inhibitor selectively targets teratocarcinoma and embryonic carcinoma cells
|
Hoang, Nam
|
|
|
26 |
8 |
p. 1523-1537
|
artikel
|
| 44 |
New phenylaniline derivatives as modulators of amyloid protein precursor metabolism
|
Gay, Marion
|
|
|
26 |
8 |
p. 2151-2164
|
artikel
|
| 45 |
Novel 4-aminoquinazoline derivatives induce growth inhibition, cell cycle arrest and apoptosis via PI3Kα inhibition
|
Fan, Yan-Hua
|
|
|
26 |
8 |
p. 1675-1685
|
artikel
|
| 46 |
Novel 6-aryl substituted 4-pyrrolidineaminoquinazoline derivatives as potent phosphoinositide 3-kinase delta (PI3Kδ) inhibitors
|
Xin, Minhang
|
|
|
26 |
8 |
p. 2028-2040
|
artikel
|
| 47 |
Novel quinazoline derivatives bearing various 6-benzamide moieties as highly selective and potent EGFR inhibitors
|
Hou, Weijie
|
|
|
26 |
8 |
p. 1740-1750
|
artikel
|
| 48 |
PET probe detecting non-small cell lung cancer susceptible to epidermal growth factor receptor tyrosine kinase inhibitor therapy
|
Makino, Akira
|
|
|
26 |
8 |
p. 1609-1613
|
artikel
|
| 49 |
Pharmacophore requirements for HIV-1 reverse transcriptase inhibitors that selectively “Freeze” the pre-translocated complex during the polymerization catalytic cycle
|
Lacbay, Cyrus M.
|
|
|
26 |
8 |
p. 1713-1726
|
artikel
|
| 50 |
pH-dependent production of himeic acid A and its non-enzymatic conversions to himeic acids B and C
|
Katsuki, Ayako
|
|
|
26 |
8 |
p. 1869-1874
|
artikel
|
| 51 |
Probing biological activity through structural modelling of ligand-receptor interactions of 2,4-disubstituted thiazole retinoids
|
Haffez, Hesham
|
|
|
26 |
8 |
p. 1560-1572
|
artikel
|
| 52 |
Sequence-specific DNA binding Pyrrole–imidazole polyamides and their applications
|
Kawamoto, Yusuke
|
|
|
26 |
8 |
p. 1393-1411
|
artikel
|
| 53 |
Structural basis of the broad substrate tolerance of the antibody 7B9-catalyzed hydrolysis of p-nitrobenzyl esters
|
Miyamoto, Naoki
|
|
|
26 |
8 |
p. 1412-1417
|
artikel
|
| 54 |
Structural design, synthesis and substituent effect of hydrazone-N-acylhydrazones reveal potent immunomodulatory agents
|
Meira, Cássio S.
|
|
|
26 |
8 |
p. 1971-1985
|
artikel
|
| 55 |
Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles
|
Sutherland, Hamish S.
|
|
|
26 |
8 |
p. 1797-1809
|
artikel
|
| 56 |
Structure optimization and preliminary bioactivity evaluation of N-hydroxybenzamide-based HDAC inhibitors with Y-shaped cap
|
Yu, Chenggong
|
|
|
26 |
8 |
p. 1859-1868
|
artikel
|
| 57 |
Studies on non-steroidal inhibitors of aromatase enzyme; 4-(aryl/heteroaryl)-2-(pyrimidin-2-yl)thiazole derivatives
|
Sahin, Zafer
|
|
|
26 |
8 |
p. 1986-1995
|
artikel
|
| 58 |
Sulfamic acid promoted one-pot synthesis of phenanthrene fused-dihydrodibenzo-quinolinones: Anticancer activity, tubulin polymerization inhibition and apoptosis inducing studies
|
Kumar, Niggula Praveen
|
|
|
26 |
8 |
p. 1996-2008
|
artikel
|
| 59 |
Synthesis and biological evaluation of histone deacetylase and DNA topoisomerase II-Targeted inhibitors
|
Yamashita, Mitsuaki
|
|
|
26 |
8 |
p. 1920-1928
|
artikel
|
| 60 |
Synthesis and biological evaluation of pyrimidine derivatives as novel human Pin1 inhibitors
|
Cui, Guonan
|
|
|
26 |
8 |
p. 2186-2197
|
artikel
|
| 61 |
Synthesis and evaluation of a novel ‘off-on’ chemical sensor based on rhodamine B and the 2,5-pyrrolidinedione moiety for selective discrimination of glutathione and its bioimaging in living cells
|
Xue, Zhenzhen
|
|
|
26 |
8 |
p. 1823-1831
|
artikel
|
| 62 |
Synthesis and evaluation of 4′,5′-dihydrospiro[piperidine-4,7′-thieno[2,3-c]pyran] analogues against both active and dormant Mycobacterium tuberculosis
|
Alluri, Kiran Kumar
|
|
|
26 |
8 |
p. 1462-1469
|
artikel
|
| 63 |
Synthesis and evaluation of 2,9-disubstituted 8-phenylthio/phenylsulfinyl-9H-purine as new EGFR inhibitors
|
Hei, Yuan-Yuan
|
|
|
26 |
8 |
p. 2173-2185
|
artikel
|
| 64 |
Synthesis and evaluation of 1H-pyrrole-2,5-dione derivatives as cholesterol absorption inhibitors for suppressing the formation of foam cells and inflammatory response
|
Yuan, Xinrui
|
|
|
26 |
8 |
p. 1435-1447
|
artikel
|
| 65 |
Synthesis and evaluation of novel dolastatin 10 derivatives for versatile conjugations
|
Yokosaka, Shinya
|
|
|
26 |
8 |
p. 1643-1652
|
artikel
|
| 66 |
Synthesis and fungicidal activity of novel imidazole-based ketene dithioacetals
|
Jeanmart, Stephane
|
|
|
26 |
8 |
p. 2009-2016
|
artikel
|
| 67 |
Synthesis and SAR study of new hydroxy and chloro-substituted 2,4-diphenyl 5H-chromeno[4,3-b]pyridines as selective topoisomerase IIα-targeting anticancer agents
|
Magar, Til Bahadur Thapa
|
|
|
26 |
8 |
p. 1909-1919
|
artikel
|
| 68 |
Synthesis, antitumor activity and DNA binding features of benzothiazolyl and benzimidazolyl substituted isoindolines
|
Sović, Irena
|
|
|
26 |
8 |
p. 1950-1960
|
artikel
|
| 69 |
Synthesis, evaluation and CoMFA/CoMSIA study of nitrofuranyl methyl N-heterocycles as novel antitubercular agents
|
Wang, Apeng
|
|
|
26 |
8 |
p. 2073-2084
|
artikel
|
| 70 |
Synthesis of 3-aza[4.4.3]propellanes with high σ1 receptor affinity
|
Torres-Gómez, Héctor
|
|
|
26 |
8 |
p. 1705-1712
|
artikel
|
| 71 |
Synthesis, photophysical properties, and photodynamic activity of positional isomers of TFPP-glucose conjugates
|
Fadlan, Arif
|
|
|
26 |
8 |
p. 1848-1858
|
artikel
|
| 72 |
Synthesis, structure-activity relationships and preliminary mechanism study of N-benzylideneaniline derivatives as potential TLR2 inhibitors
|
Cai, Shaoyi
|
|
|
26 |
8 |
p. 2041-2050
|
artikel
|
| 73 |
Targeting RORs nuclear receptors by novel synthetic steroidal inverse agonists for autoimmune disorders
|
Dal Prà, Matteo
|
|
|
26 |
8 |
p. 1686-1704
|
artikel
|
| 74 |
The discovery of novel diarylpyri(mi)dine derivatives with high level activity against a wide variety of HIV-1 strains as well as against HIV-2
|
Lu, Xueyi
|
|
|
26 |
8 |
p. 2051-2060
|
artikel
|
| 75 |
Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells
|
Wei, Xin
|
|
|
26 |
8 |
p. 1776-1783
|
artikel
|
| 76 |
Xanthone derivatives as phosphoglycerate mutase 1 inhibitors: Design, synthesis, and biological evaluation
|
Wang, Penghui
|
|
|
26 |
8 |
p. 1961-1970
|
artikel
|
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