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                             76 results found
no title author magazine year volume issue page(s) type
1 A combination of 19F NMR and surface plasmon resonance for site-specific hit selection and validation of fragment molecules that bind to the ATP-binding site of a kinase Nagatoishi, Satoru

26 8 p. 1929-1938
article
2 Adenosine analogs bearing phosphate isosteres as human MDO1 ligands Zhang, Yuezhou

26 8 p. 1588-1597
article
3 A novel series of 4-methyl substituted pyrazole derivatives as potent glucagon receptor antagonists: Design, synthesis and evaluation of biological activities Shu, Shuangjie

26 8 p. 1896-1908
article
4 Aralkyl selenoglycosides and related selenosugars in acetylated form activate protein phosphatase-1 and -2A Kónya, Zoltán

26 8 p. 1875-1884
article
5 A Rhodamine B-based fluorescent probe for imaging Cu2+ in maize roots Lv, Ting

26 8 p. 1448-1452
article
6 2-Arylthio-5-iodo pyrimidine derivatives as non-nucleoside HBV polymerase inhibitors Wang, Jie

26 8 p. 1573-1578
article
7 Borrelidins F–I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89 Sun, Jianbin

26 8 p. 1488-1494
article
8 Design and synthesis of 1-(1-benzothiophen-7-yl)-1H-pyrazole, a novel series of G protein-coupled receptor 52 (GPR52) agonists Nakahata, Takashi

26 8 p. 1598-1608
article
9 Design and synthesis of estrogen receptor ligands with a 4-heterocycle-4-phenylheptane skeleton Eto, Ryo

26 8 p. 1638-1642
article
10 Design, synthesis and biological assessment of N-adamantyl, substituted adamantyl and noradamantyl phthalimidines for nitrite, TNF-α and angiogenesis inhibitory activities Luo, Weiming

26 8 p. 1547-1559
article
11 Design, synthesis and biological evaluation of anti-pancreatic cancer activity of plinabulin derivatives based on the co-crystal structure Fu, Zhangyu

26 8 p. 2061-2072
article
12 Design, synthesis and biological evaluation of novel 7-azaspiro[3.5]nonane derivatives as GPR119 agonists Matsuda, Daisuke

26 8 p. 1832-1847
article
13 Design, synthesis and biological evaluation of novel hydroxamic acid based histone deacetylase 6 selective inhibitors bearing phenylpyrazol scaffold as surface recognition motif Yang, Jinyu

26 8 p. 1418-1425
article
14 Design, synthesis and biological evaluation of novel 3-substituted pyrazolopyrimidine derivatives as potent Bruton’s tyrosine kinase (BTK) inhibitors Zheng, Nan

26 8 p. 2165-2172
article
15 Design, synthesis, and evaluation of the antiproliferative activity of hydantoin-derived antiandrogen-genistein conjugates George, Alex

26 8 p. 1481-1487
article
16 Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno[3′,2′:3,4]pyrido[1,2-b]isoquinoline and 5,8,12,12a-tetrahydro-6H-thieno[2′,3′:4,5]pyrido[2,1-a]isoquinoline derivatives as cellular activators of adenosine 5′-monophosphate-activated protein kinase (AMPK) Gu, Zhanni

26 8 p. 2017-2027
article
17 Development of a microbioreactor for glycoconjugate synthesis Haneda, Katsuji

26 8 p. 2092-2098
article
18 Development of benzoxazole deoxybenzoin oxime and acyloxylamine derivatives targeting innate immune sensors and xanthine oxidase for treatment of gout Huang, Jun

26 8 p. 1653-1664
article
19 Development of selective inhibitors for the treatment of rheumatoid arthritis: (R)-3-(3-(Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)-3-oxopropanenitrile as a JAK1-selective inhibitor Chough, Chieyeon

26 8 p. 1495-1510
article
20 2,4-Diamino-8-quinazoline carboxamides as novel, potent inhibitors of the NAD hydrolyzing enzyme CD38: Exploration of the 2-position structure-activity relationships Deaton, David N.

26 8 p. 2107-2150
article
21 Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors Rohde, Jason M.

26 8 p. 1727-1739
article
22 Discovery and optimization of tetrahydropyrido[4,3-d]pyrimidine derivatives as novel ATX and EGFR dual inhibitors Jing, Tongfei

26 8 p. 1784-1796
article
23 Discovery of DSP-1053, a novel benzylpiperidine derivative with potent serotonin transporter inhibitory activity and partial 5-HT1A receptor agonistic activity Yoshinaga, Hidefumi

26 8 p. 1614-1627
article
24 Discovery of 18β-glycyrrhetinic acid conjugated aminobenzothiazole derivatives as Hsp90-Cdc37 interaction disruptors that inhibit cell migration and reverse drug resistance Jin, Le

26 8 p. 1759-1775
article
25 Discovery of isatin and 1H-indazol-3-ol derivatives as d-amino acid oxidase (DAAO) inhibitors Szilágyi, Bence

26 8 p. 1579-1587
article
26 Discovery of novel 4-aryl-thieno[1,4]diazepin-2-one derivatives targeting multiple protein kinases as anticancer agents Lee, Junghun

26 8 p. 1628-1637
article
27 Discovery of potent DOT1L inhibitors by AlphaLISA based High Throughput Screening assay Song, Yakai

26 8 p. 1751-1758
article
28 Discovery of selective EGFR modulator to inhibit L858R/T790M double mutants bearing a N-9-Diphenyl-9H-purin-2-amine scaffold Hu, Jinxing

26 8 p. 1810-1822
article
29 Editorial Board
26 8 p. ii
article
30 Enhancing the anti-biofilm activity of 5-aryl-2-aminoimidazoles through nature inspired dimerisation Trang, Tran Thi Thu

26 8 p. 1470-1480
article
31 Fine-tuning the physicochemical properties of peptide-based blood–brain barrier shuttles Ghasemy, Somaye

26 8 p. 2099-2106
article
32 Fluorine-18 labeling of an anti-HER2 VHH using a residualizing prosthetic group via a strain-promoted click reaction: Chemistry and preliminary evaluation Zhou, Zhengyuan

26 8 p. 1939-1949
article
33 Graphical abstract TOC
26 8 p. IBC
article
34 Graphical abstract TOC
26 8 p. OBC
article
35 Graphical abstract TOC continued
26 8 p. IV-XX
article
36 High expression of integrin αvβ3 enables uptake of targeted fluorescent probes into ovarian cancer cells and tumors Shaw, Scott K.

26 8 p. 2085-2091
article
37 Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion Wilke, Julian

26 8 p. 1453-1461
article
38 Identification of novel PDEδ interacting proteins Küchler, Philipp

26 8 p. 1426-1434
article
39 In silico studies, synthesis and pharmacological evaluation to explore multi-targeted approach for imidazole analogues as potential cholinesterase inhibitors with neuroprotective role for Alzheimer’s disease Gurjar, Archana S.

26 8 p. 1511-1522
article
40 Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer’s disease Lu, Xin

26 8 p. 1665-1674
article
41 Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine Hanaki, Mizuho

26 8 p. 1538-1546
article
42 Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer’s disease Xu, Rui

26 8 p. 1885-1895
article
43 New histone demethylase LSD1 inhibitor selectively targets teratocarcinoma and embryonic carcinoma cells Hoang, Nam

26 8 p. 1523-1537
article
44 New phenylaniline derivatives as modulators of amyloid protein precursor metabolism Gay, Marion

26 8 p. 2151-2164
article
45 Novel 4-aminoquinazoline derivatives induce growth inhibition, cell cycle arrest and apoptosis via PI3Kα inhibition Fan, Yan-Hua

26 8 p. 1675-1685
article
46 Novel 6-aryl substituted 4-pyrrolidineaminoquinazoline derivatives as potent phosphoinositide 3-kinase delta (PI3Kδ) inhibitors Xin, Minhang

26 8 p. 2028-2040
article
47 Novel quinazoline derivatives bearing various 6-benzamide moieties as highly selective and potent EGFR inhibitors Hou, Weijie

26 8 p. 1740-1750
article
48 PET probe detecting non-small cell lung cancer susceptible to epidermal growth factor receptor tyrosine kinase inhibitor therapy Makino, Akira

26 8 p. 1609-1613
article
49 Pharmacophore requirements for HIV-1 reverse transcriptase inhibitors that selectively “Freeze” the pre-translocated complex during the polymerization catalytic cycle Lacbay, Cyrus M.

26 8 p. 1713-1726
article
50 pH-dependent production of himeic acid A and its non-enzymatic conversions to himeic acids B and C Katsuki, Ayako

26 8 p. 1869-1874
article
51 Probing biological activity through structural modelling of ligand-receptor interactions of 2,4-disubstituted thiazole retinoids Haffez, Hesham

26 8 p. 1560-1572
article
52 Sequence-specific DNA binding Pyrrole–imidazole polyamides and their applications Kawamoto, Yusuke

26 8 p. 1393-1411
article
53 Structural basis of the broad substrate tolerance of the antibody 7B9-catalyzed hydrolysis of p-nitrobenzyl esters Miyamoto, Naoki

26 8 p. 1412-1417
article
54 Structural design, synthesis and substituent effect of hydrazone-N-acylhydrazones reveal potent immunomodulatory agents Meira, Cássio S.

26 8 p. 1971-1985
article
55 Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles Sutherland, Hamish S.

26 8 p. 1797-1809
article
56 Structure optimization and preliminary bioactivity evaluation of N-hydroxybenzamide-based HDAC inhibitors with Y-shaped cap Yu, Chenggong

26 8 p. 1859-1868
article
57 Studies on non-steroidal inhibitors of aromatase enzyme; 4-(aryl/heteroaryl)-2-(pyrimidin-2-yl)thiazole derivatives Sahin, Zafer

26 8 p. 1986-1995
article
58 Sulfamic acid promoted one-pot synthesis of phenanthrene fused-dihydrodibenzo-quinolinones: Anticancer activity, tubulin polymerization inhibition and apoptosis inducing studies Kumar, Niggula Praveen

26 8 p. 1996-2008
article
59 Synthesis and biological evaluation of histone deacetylase and DNA topoisomerase II-Targeted inhibitors Yamashita, Mitsuaki

26 8 p. 1920-1928
article
60 Synthesis and biological evaluation of pyrimidine derivatives as novel human Pin1 inhibitors Cui, Guonan

26 8 p. 2186-2197
article
61 Synthesis and evaluation of a novel ‘off-on’ chemical sensor based on rhodamine B and the 2,5-pyrrolidinedione moiety for selective discrimination of glutathione and its bioimaging in living cells Xue, Zhenzhen

26 8 p. 1823-1831
article
62 Synthesis and evaluation of 4′,5′-dihydrospiro[piperidine-4,7′-thieno[2,3-c]pyran] analogues against both active and dormant Mycobacterium tuberculosis Alluri, Kiran Kumar

26 8 p. 1462-1469
article
63 Synthesis and evaluation of 2,9-disubstituted 8-phenylthio/phenylsulfinyl-9H-purine as new EGFR inhibitors Hei, Yuan-Yuan

26 8 p. 2173-2185
article
64 Synthesis and evaluation of 1H-pyrrole-2,5-dione derivatives as cholesterol absorption inhibitors for suppressing the formation of foam cells and inflammatory response Yuan, Xinrui

26 8 p. 1435-1447
article
65 Synthesis and evaluation of novel dolastatin 10 derivatives for versatile conjugations Yokosaka, Shinya

26 8 p. 1643-1652
article
66 Synthesis and fungicidal activity of novel imidazole-based ketene dithioacetals Jeanmart, Stephane

26 8 p. 2009-2016
article
67 Synthesis and SAR study of new hydroxy and chloro-substituted 2,4-diphenyl 5H-chromeno[4,3-b]pyridines as selective topoisomerase IIα-targeting anticancer agents Magar, Til Bahadur Thapa

26 8 p. 1909-1919
article
68 Synthesis, antitumor activity and DNA binding features of benzothiazolyl and benzimidazolyl substituted isoindolines Sović, Irena

26 8 p. 1950-1960
article
69 Synthesis, evaluation and CoMFA/CoMSIA study of nitrofuranyl methyl N-heterocycles as novel antitubercular agents Wang, Apeng

26 8 p. 2073-2084
article
70 Synthesis of 3-aza[4.4.3]propellanes with high σ1 receptor affinity Torres-Gómez, Héctor

26 8 p. 1705-1712
article
71 Synthesis, photophysical properties, and photodynamic activity of positional isomers of TFPP-glucose conjugates Fadlan, Arif

26 8 p. 1848-1858
article
72 Synthesis, structure-activity relationships and preliminary mechanism study of N-benzylideneaniline derivatives as potential TLR2 inhibitors Cai, Shaoyi

26 8 p. 2041-2050
article
73 Targeting RORs nuclear receptors by novel synthetic steroidal inverse agonists for autoimmune disorders Dal Prà, Matteo

26 8 p. 1686-1704
article
74 The discovery of novel diarylpyri(mi)dine derivatives with high level activity against a wide variety of HIV-1 strains as well as against HIV-2 Lu, Xueyi

26 8 p. 2051-2060
article
75 Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells Wei, Xin

26 8 p. 1776-1783
article
76 Xanthone derivatives as phosphoglycerate mutase 1 inhibitors: Design, synthesis, and biological evaluation Wang, Penghui

26 8 p. 1961-1970
article
                             76 results found
 
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