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| Titel: |
THE ROLE OF PLASMA MEMBRANE Ca2+-ATPase IN EXCITABLE CELLS SIGNALING |
| Auteur: |
Ludmila Zylinska |
| Verschenen in: |
Electronic journal of pathology and histopathology |
| Paginering: | Jaargang 6 (2002) nr. 1 pagina's 14 |
| Jaar: |
2002-03-25 |
| Inhoud: |
During the last decade the mechanisms of Ca2+ regulation in the brain have been extensively investigated in a variety of neural cells. These investigations demonstrate that intraneuronal Ca2+ participate in the multiple controls of important neural functions, like excitability, neurotransmitters release or long-term changes in synaptic efficacy. Moreover, there is a significant number of data confirming that the impairment of calcium homeostasis is closely linked with aging and several brain disorders. The plasma membrane Ca2+-ATPase (PMCA) is a ubiquitously expressed protein, which constitutes a high affinity system extruding Ca2+ outside the cell and maintains the intracellular Ca2+ in the submicromolar range in a resting state. In neuronal tissues more than 26 transcripts of the four separate PMCA genes are distributed in a region specific manner. Differences in the structure and localization of PMCA variants are thought to correlate with specific regulatory properties and may have consequences for proper Ca2+ signaling or for the response to the brain malfunction. Below some new aspects of the Ca2+-ATPase modulation in physiological and pathological conditions will be discussed which may influence neuronal calcium signaling. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 16 van 17 gevonden artikelen
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