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Details for article 15 of 17 found articles
| Title: |
Signal transduction and regulation of the epidermal growth factor receptor |
| Author: |
Hongbing Li Paloma I. Palomo-Jiménez María José Ruano Antonio Villalobo |
| Appeared in: |
Electronic journal of pathology and histopathology |
| Paging: | Volume 6 (2002) nr. 1 pages 07 |
| Year: |
2002-03-25 |
| Contents: |
The epidermal growth factor receptor (EGFR) is a plasma membrane tyrosine kinase that belongs, together with other three related members, to the ErbB family of receptors. These receptors share a large group of polypeptide ligands, that induce homodimerization or heterodimerization among themselves, and the activation of their intrinsic tyrosine kinases followed by their transphosphorylation. The active phosphorylated receptors generate a series of signaling events conducted to initiate cell proliferation, differentiation and/or antiapoptotic responses. In this short review it will be analysed some major signaling pathways initiated by EGFR activation, the regulatory mechanisms controlling its tyrosine kinase activity, some of which are mediated by the calcium signal generated by the own receptor, and its downregulation and internalisation. Moreover, the cross-talk between the EGFR and other ErbB family members, and between the EGFR and other non-related receptors, will be described. Finally, the importance of this receptor in embryogenesis and in proliferative processes in adult individuals will be analysed by the description of some genetic alterations that result in the occurrence of important foetal malformations and the generation of cancerous tumors. |
| Publisher: |
IOS Press |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 15 of 17 found articles
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