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| Titel: |
High Education May Offer Protection Against Tauopathy in Patients with Mild Cognitive Impairment |
| Auteur: |
Rolstad, Sindre Nordlund, Arto Eckerström, Carl Gustavsson, Marie H. Blennow, Kaj Olesen, Pernille J. Zetterberg, Henrik Wallin, Anders |
| Verschenen in: |
Journal of Alzheimer's disease |
| Paginering: | Jaargang 21 (2010) nr. 1 pagina's 221-228 |
| Jaar: |
2010-04-22 |
| Inhoud: |
The concepts of brain and cognitive reserve stem from the observation that premorbid factors (e.g., education) result in variation in the response to brain pathology. Potential early influence of reserve on pathology, as assessed using the cerebrospinal fluid biomarkers total tau (t-tau) and amyloid-β42, and cognition was explored in mild cognitive impairment (MCI) patients who remained stable over a two-year period. A total of 102 patients with stable MCI grouped on the basis of educational level were compared with regard to biomarker concentrations and cognitive performance. Stable MCI patients with higher education had lower concentrations of t-tau as compared to those with lower education. Also, educational level predicted a significant proportion of the total variance in t-tau concentrations. Our results suggest that higher education may offer protection against tauopathy. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 5 van 30 gevonden artikelen
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