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Details for article 4 of 30 found articles
| Title: |
Cerebrospinal Fluid from Alzheimer's Disease Patients Promotes Amyloid β-Protein Oligomerization |
| Author: |
Ikeda, Tokuhei Ono, Kenjiro Elashoff, David Condron, Margaret M. Noguchi-Shinohara, Moeko Yoshita, Mitsuhiro Teplow, David B. Yamada, Masahito |
| Appeared in: |
Journal of Alzheimer's disease |
| Paging: | Volume 21 (2010) nr. 1 pages 81-86 |
| Year: |
2010-04-22 |
| Contents: |
Oligomers of the amyloid β-protein (Aβ) play an important role in Alzheimer's disease (AD). We hypothesized that AD patients have a central nervous system environment that promotes Aβ oligomerization. We investigated the effect of cerebrospinal fluid (CSF) from 33 patients with AD and 33 age-matched, non-demented controls on oligomerization of Aβ1-40 and Aβ1-42 using the technique of photo-induced cross-linking of unmodified proteins. CSF inhibited oligomerization of both Aβ1-40 and Aβ1-42. This inhibitory effect was significantly weaker in AD patients than in non-demented controls. Our results indicate that AD patients have a CSF environment favorable for Aβ oligomerization. |
| Publisher: |
IOS Press |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 4 of 30 found articles
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