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Details van artikel 5 van 12 gevonden artikelen
| Titel: |
Mitochondrial Oxidant Signalling in Alzheimer's Disease |
| Auteur: |
Viña, Jose Lloret, Ana Vallés, Soraya L. Borrás, Consuelo Badía, Mari-Carmen Pallardó, Federico V. Sastre, Juan Alonso, Maria-Dolores |
| Verschenen in: |
Journal of Alzheimer's disease |
| Paginering: | Jaargang 11 (2007) nr. 2 pagina's 175-181 |
| Jaar: |
2007-05-21 |
| Inhoud: |
The role of free radicals in Alzheimer disease pathophysiology has been appreciated for a long time. Originally, radicals were considered as causative of oxidative damage. More recently their role as signalling molecules in this, as well as in other fields of free radical biology, has been underscored. Mitochondria are both generators and targets of radical damage in aging. In this paper we review evidence that radicals generated in mitochondria in the presence of Aβ are signals that trigger both the mitochondrial and the extra-mitochondrial pathways of apoptosis. There are gender specific differences in mitochondrial Aβ toxicity: mitochondria from young (but not from old) females appear to be protected. 17-β Estradiol or phytoestrogens like genistein prevent the formation of oxidants by mitochondria and protect against mitochondrial Aβ toxicity. Experiments reported here indicate that phytoestrogens might have a role in the prevention of Alzheimer's disease. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 5 van 12 gevonden artikelen
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