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| Titel: |
Correlation between Platelet Amyloid Precursor Protein Isoform Ratio and Cognition in Alzheimer's Disease |
| Auteur: |
Liu, Hsiu-Chih Wang, Hsiao-Chien Ko, Shun-Yao Wang, Pei-Ning Chi, Chin-Wen Hong, Chen-Jee Lin, Ker-Neng Liu, Tsung-Yun |
| Verschenen in: |
Journal of Alzheimer's disease |
| Paginering: | Jaargang 11 (2007) nr. 1 pagina's 77-84 |
| Jaar: |
2007-03-15 |
| Inhoud: |
This study analyzed whether platelet amyloid β-protein precursor (AβPP) isoform ratio correlates with cognition or cognitive decline in patients with Alzheimer's disease (AD). Platelet AβPP isoform ratio was measured, and cognitive assessment was performed using the Mini-Mental State Examination (MMSE) in 66 AD patients at baseline (T0) and in 29 of these patients in a one-year follow-up (T1). There was a significant correlation between the AβPP isoform ratios and MMSE scores in the 66 AD patients at T0. The T1 subjects were divided into two groups: 12 "no decliners" (MMSE score, T1-T0 ⩾ 0) and 17 "decliners" (MMSE score, T1-T0 < 0). The decliners group showed a significantly greater reduction of AβPP isoform ratio from T0 to T1 than the no decliners group. However, the decline of the ratio did not correlate with the decline of MMSE score. These findings indicate that AβPP isoform ratio correlates with cognition, and reduction in this ratio may be a marker for cognitive decline in AD patients. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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