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Details van artikel 5 van 18 gevonden artikelen
| Titel: |
Comparative Effects of Aβ_{(1-42)}-Al Complex from Rat and Human Amyloid on Rat Endothelial Cell Cultures |
| Auteur: |
Drago, Denise Folin, Marcella Baiguera, Silvia Tognon, Giuseppe Ricchelli, Fernanda Zatta, Paolo |
| Verschenen in: |
Journal of Alzheimer's disease |
| Paginering: | Jaargang 11 (2007) nr. 1 pagina's 33-44 |
| Jaar: |
2007-03-15 |
| Inhoud: |
Metal ions are widely recognized as a key factor for the conformational changes and aggregation of the Alzheimer's disease amyloid (Aβ). So far Al^{3+} has received much less attention than other biometals in terms of interaction with Aβ. Brain endothelial cells have been identified as important regulators of the neuronal microenvironment, including Aβ levels. The purpose of this study is to compare the effects of the complex amyloid (Aβ _{1-42})-Al, from human and rat, with the effects produced by metal-free Aβ on rat neuroendothelial cells (NECs). To establish Aβ and Aβ-Al toxicity on NECs, survival, vitality, and angiogenesis are evaluated. Cell survival is reduced by human and rat Aβ in a time-dependent manner. This toxic effect is remarkably pronounced in the presence of human Aβ-Al. Moreover, rat Aβ has anti-angiogenic properties on NECs, and this effect is aggravated dramatically by using both human and rat Aβ-Al complexes. The data and arguments presented herein clearly demonstrate the involvement of Al^{3+} in Aβ aggregation and, consequently, increasing endothelial cell toxicity. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 5 van 18 gevonden artikelen
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