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| Titel: |
The Matrix Reloaded: New Insights from Type IV Collagen Derived Endogenous Angiogenesis Inhibitors and their Mechanism of Action |
| Auteur: |
Akulapalli Sudhakar |
| Verschenen in: |
Journal of bioequivalence & bioavailability |
| Paginering: | Jaargang 01 (2009) nr. 02 pagina's 052-062 |
| Jaar: |
2009 |
| Inhoud: |
Angiogenesis, the process of neovascularization from parent blood vessels, is a prerequisite for many physiological and pathological conditions that is regulated by a balance between the levels of endogenous angiogenic stimulators and matrix reloaded angiogenic regulators. Several non-collagenous carboxy terminal end domains inchains of type IV collagen matrix reloaded molecules selectively interact with proliferating endothelial cells by binding to distinct integrins and regulate intracellular signaling and inhibit angiogenesis. This review will focus on the current understanding of extra cellular matrix type IV collagen reloaded endogenous angiogenesis inhibitors and their mechanism of action. |
| Uitgever: |
OMICS Publishing Group (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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