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| Titel: |
Solubility and Dissolution Improvement of Aceclofenac using Different Nanocarriers |
| Auteur: |
Faiyaz Shakeel Wafa Ramadan Sheikh Shafiq |
| Verschenen in: |
Journal of bioequivalence & bioavailability |
| Paginering: | Jaargang 01 (2009) nr. 02 pagina's 039-043 |
| Jaar: |
2009 |
| Inhoud: |
The aim of the present investigation was to improve solubility and dissolution of the lipophilic drug aceclofenac using three nanocarriers namely nanoemulsion, solid lipid nanosuspension and polymeric nanosuspension. The solubility of aceclofenac in distilled water and different nanocarriers was determined using the UV spectrophotometer method at the wavelength of 274 nm. Dissolution studies of pure aceclofenac suspension and its nanocarriers were performed using USP dissolution apparatus in distilled water. The highest solubility (198.53 mg/ml) as well as % dissolution (99.5) of aceclofenac was obtained with nanoemulsion formulation as comparedto lipid and polymeric nanosuspension. The results of solubility and dissolution were highly significant in nanoemulsion as compared to lipid and polymeric nanosuspension (P<0.01). Dissolution profile of aceclofenac in lipid and polymeric nanosuspension was significant as compared to pure aceclofenac suspension (P<0.05). These results indicated that nanoemulsion is a promising nanocarrier as compared to lipid and polymeric nanosuspension for solubility and dissolution enhancement of aceclofenac. |
| Uitgever: |
OMICS Publishing Group (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 4 van 5 gevonden artikelen
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