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Details van artikel 4 van 8 gevonden artikelen
| Titel: |
Down syndrome and coexistent autoimmune diseases |
| Auteur: |
Dimitry Chistiakov |
| Verschenen in: |
Journal of applied biomedicine |
| Paginering: | Jaargang 5 (2007) nr. 2 pagina's 71-76 |
| Jaar: |
2007 |
| Inhoud: |
Down syndrome (DS) is often accompanied by autoimmune diseases. Among those, autoimmune thyroiddisease, type 1 diabetes and celiac disease are the most common. The major cause of enhancedvulnerability of DS patients to a variety of autoimmune diseases is impaired immune response, withmultiple abnormalities in all components of the immune system, especially in cell-mediated immunity.This could explain a significantly higher frequency of autoimmune disorders in DS compared to thegeneral population. The diagnosis of autoimmune diseases accompanying DS could be complicated bymasking effects of the underlying features of the syndrome such as failure to thrive, short stature anddelayed puberty. However, screening for immunological signs of coexistent autoimmunity such as tissuespecificantibodies and monitoring insulin secretion, glucose levels, thyroid function and other metabolicparameters should help in early diagnosis of coexistent autoimmunity in DS patiens. |
| Uitgever: |
University of South Bohemia (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 4 van 8 gevonden artikelen
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