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| Titel: |
Assay of radical scavenging activity of antidotes against chemical warfare agents by DPPH test using sequential injection technique |
| Auteur: |
Vit Koleckar Daniel Jun Lubos Opletal Ludek Jahodar Kamil Kuca |
| Verschenen in: |
Journal of applied biomedicine |
| Paginering: | Jaargang 5 (2007) nr. 2 pagina's 81-84 |
| Jaar: |
2007 |
| Inhoud: |
Free radicals are believed to play an important role in many pathological states. Consequentlyantioxidants are receiving increased attention in medicinal research. As part of studies of the biologicaleffects of the antidotes against chemical warfare agents currently used in the Czech Armed Forces, elevencompounds were assayed for their free radical scavenging activity. An optimized PC-controlled sequentialinjection analysis (SIA) system with spectrophotometric detection was used for evaluation of theantioxidation activity of the antidotes. The automated method is based on the known reaction of 2,2ยด-diphenyl-1-picrylhydrazyl radical (DPPH) with antioxidants. Only the radical scavenging activity of thetested compound 2,3-dimercaptopropanol (BAL) was found to be weaker compared to the referenceantioxidant acidum ascorbicum. Other tested antidotes did not possess any DPPH radical scavengingactivity. The results obtained show that a correlation between the required biological activity (prophylaxisor treatment of intoxications by warfare agents) and possible antioxidation activity of the tested antidotesis doubtful. |
| Uitgever: |
University of South Bohemia (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 3 van 8 gevonden artikelen
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