Protective role of tetrahydrocurcumin on changes in the fatty acid composition in streptozotocin - nicotinamide induced type 2 diabetic rats
Titel:
Protective role of tetrahydrocurcumin on changes in the fatty acid composition in streptozotocin - nicotinamide induced type 2 diabetic rats
Auteur:
Pidaran Murugan Leelavinothan Pari
Verschenen in:
Journal of applied biomedicine
Paginering:
Jaargang 5 (2007) nr. 1 pagina's 31-38
Jaar:
2007
Inhoud:
Curcumin is the most active component of turmeric. It is believed that curcumin is a potent antioxidantand anti-inflammatory agent. Tetrahydrocurcumin (THC), one of the major metabolites of curcumin,exhibits many of the same physiological and pharmacological activities as curcumin and in some systemsmay exert greater antioxidant activity than curcumin. The aim of this study was to evaluate the effect ofTHC on the blood glucose, plasma insulin and fatty acid composition of the total lipids in the liver,kidney and brain of control and streptozotocin (STZ)-nicotinamide diabetic rats. The analysis of fattyacids showed that there was a significant increase in the concentrations of palmitic acid (16:1), stearicacid (18:0) and oleic acid (18:1) in the liver, kidney and brain, whereas the concentrations of linolenicacid (18:3) and arachidonic acid (20:4) were significantly decreased. Oral administration of the THC (80mg/kg body weight) for 45 days to diabetic rats decreased the concentrations of fatty acids, viz., palmitic,stearic, and oleic acid, whereas linolenic and arachidonic acid were elevated. These results suggest thatTHC exhibits antidiabetic and antihyperlipidemic effects in STZ-nicotinamide induced diabetic rats. Italso prevents the fatty acid changes produced during diabetes. The antidiabetic and antihyperlipidemiceffects of THC are more potent than those of curcumin at the same dose. The results of the present studyindicate that THC showed an antihyperlipidemic effect in addition to its antidiabetic effect in type 2diabetic rats.
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