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| Titel: |
From oxidative DNA damage to molecular epidemiology |
| Auteur: |
Katarina Volkovova Maria Dusinska Andrew R. Collins |
| Verschenen in: |
Journal of applied biomedicine |
| Paginering: | Jaargang 4 (2005) nr. 1 pagina's 39-43 |
| Jaar: |
2005 |
| Inhoud: |
Reactive forms of oxygen are released during normal respiration, by the oxidative burst of themacrophages in response to infection, and by a variety of exogenous environmental agents. Oxidativestress, caused by imbalance between the production of reactive forms of oxygen and their elimination,leads to oxidative damage of biomolecules. It is generally accepted that oxidative stress is involved eitheras cause or effect in a variety of human degenerative diseases. The antioxidant hypothesis proposes thatnatural antioxidants in fruit and vegetables scavenge free radicals before they can cause damage. To testthe hypothesis a reliable biomarker for in vivo assessment of oxidative damage is needed which can becorrelated with antioxidant levels on one hand and with disease on the other. Oxidative damage tolymphocyte DNA can be measured by the comet assay or by HPLC. This paper gives a brief review ofthe methods and their application both in in vitro and in in vivo studies dealing with mutagenesis andcarcinogenesis. Molecular epidemiological studies in Slovakia concerning different disease states, agingand the role of diet, and antioxidant supplementation in prevention are reviewed as well. |
| Uitgever: |
University of South Bohemia (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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