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| Titel: |
Chronobiology’s progress: season's appreciations 2004-2005: time-, frequency-, phase-, variable-, individual-, age- and site-specific chronomics |
| Auteur: |
Franz Halberg Germaine Cornelissen George Katinas Levan Tvildiani Marina Gigolashvili Ketevan Janashia Tim Toba Miguel Revilla Michal Zeman Philip Regal Robert B. Sothern Hans W. Wendt Zhengrong Wang Rita Jozsa R. B. Singh Gen Mitsutake Sergei M. Chibisov Jong Lee Dan Holley James E. Holte Robert P. Sonkowsky Othild Schwartzkopff Patrick Delmore Kuniaki Otsuka Earl E. Bakken Jerzy Czaplicki |
| Verschenen in: |
Journal of applied biomedicine |
| Paginering: | Jaargang 4 (2006) nr. 1 pagina's 1-38 |
| Jaar: |
2006 |
| Inhoud: |
New components of transdisciplinary spectra or known components in new variables in us, matchingthose around us, are being mapped. Their hardly trivial interactions associated with the good and badaround us – from religiosity to crime and war – are being rendered measurable, for the eventualdevelopment of countermeasures to the diseases of societies and nations. Internal cycles not only underlielife itself and underlie our evolving genetics at all levels of organization; they also constitute the essentialcontrol and reference information in all transdisciplinary science. In preparing for travel to Mars andother missions in space that may take more than a year, let us do what is immediately practicable.Transyears may have very small amplitudes yet are associated with sudden cardiac death in someterrestrial locations; if they should play a role in these electrical incidents of the heart, among others likemyocardial infarction and stroke, they will jeopardize lengthy missions in extraterrestrial space, awayfrom hospitals.The likelihood of stroke or cardiac death can be immediately reduced by chronobiologicallyassessing blood pressure and heart rate variability and by optimizing the efficacy of timed treatmentrather than relying on an unacceptable and often inaccurate spotcheck and treating by convenience ratherthan pertinence. Needed are: detection of nocturnal abnormality when medication may no longer beeffective (or is too effective) neither seen during office visits by day; detection of circadian hyperamplitude-tension (CHAT) associated with a risk of stroke and kidney disease greater than other risks (including “hypertension” when all risks are assessed concomitantly); detection of CHAT as high riskamong normotensives who may not need anti-hypertensive medication; individualized inferentialstatistical testing to determine whether a drug or non-drug intervention such as autogenic training(relaxation) is effective and for how long (detecting any initial and later success or failure), some ofwhich conditions otherwise are not found without chronobiology; individualization of treatment timing,since the same dose of the same medication can further lower the subject's blood pressure average andcircadian amplitude when the timing of daily administration is optimized, as ascertained by sequentialtesting and parameter tests.Thus, we save lives by monitoring and assessing, and if need be treating, vascular disease riskthrough chronobiologically interpreted 24-hour or preferably longer (24-hour/7-day) blood pressure andheart rate variability. Abnormalities in the variability of blood pressure and heart rate, impossible to findduring a conventional office visit (the latter aiming at the fiction of a “true” blood pressure), can raisecardiovascular disease risk in the next six years from 4% to 100%. |
| Uitgever: |
University of South Bohemia (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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