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Details van artikel 21 van 24 gevonden artikelen
| Titel: |
Relationship Between Pharmacological Potency and Surface Activity of Cholic Acid Analogs |
| Auteur: |
T.H. Zhang J. Lin C.G. Liu R.G. Ding J.X. Ruan X.H. Sun C.Q. Huang X.C. Zhang |
| Verschenen in: |
International journal of pharmacology |
| Paginering: | Jaargang 4 (2008) nr. 5 pagina's 407-409 |
| Jaar: |
2008 |
| Inhoud: |
The aim of this study was to elucidate whether changes of surface activity of cholic acid analogs may lead to alteration of its pharmacological potency. The potencies of various cholic acid analogs were explored by two mice models, Perfluoroisobutylene induced pulmonary edema and Xylene induced ear edema. Determination of the Critical Micelle Concentration (CMC), an index for the comparison of the surface activity, of cholic acid analogs was also conducted. The results showed that administration of cholic acid analogs decreased the water content in the organ with a potency of chendehydroxycholic acid > dehydroxycholic acid > ursodehydroxycholic acid > hyodehydroxycholic acid > cholic acid. This is in accordance with the sequence of CMC. We suggest, that the effects of cholic acid analogs might be closely related with their surface activity. |
| Uitgever: |
Asian Network for Scientific Information (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 21 van 24 gevonden artikelen
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