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| Titel: |
Potentiating Effect of Piperine on Hepatoprotective Activity of Boerhaavia diffusa to Combat Oxidative Stress |
| Auteur: |
S.K. Desai V.S. Gawali A.B. Naik L.L. D`souza |
| Verschenen in: |
International journal of pharmacology |
| Paginering: | Jaargang 4 (2008) nr. 5 pagina's 393-397 |
| Jaar: |
2008 |
| Inhoud: |
The hydro alcoholic extract of roots of Boerhaavia diffusa (HEBD) was evaluated for its hepatoprotective activity against CCl4 and Rifampicin - Isoniazid combination induced hepatotoxicity at two dose levels 150 and 300 mg kg-1 . HEBD exhibited a significant protective action on the liver evident by a reduction in the elevated levels of serum lysosomal enzymes namely Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transminase (SGOT), Alkaline Phosphatase (ALP) in both CCl4 and Rifampicin-Isoniazid induced hepatotoxicity. Thus HEBD showed a dose dependent hepatoprotective activity. In addition, the hepatoprotective activity of Boerhaavia diffusa was evaluated for possible potentiation in the presence of piperine based on recent research which has reported the latter enhancing bioavailability of certain drugs and nutritional compounds. Piperine was checked for potentiation, if any, at two dose levels 10 and 20 mg, respectively. Piperine was found to produce a dose dependent potentiation of the hepatoprotective activity of Boerhaavia diffusa. |
| Uitgever: |
Asian Network for Scientific Information, Pakistan (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 20 van 24 gevonden artikelen
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