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| Titel: |
The chitinase 3-like human protein 2 (CHI3L2) activates ERK1/2 signaling pathway in human embryonic kidney cells (HEK293) |
| Auteur: |
Areshkov P. O. Kavsan V. M. |
| Verschenen in: |
Biopolymers and cell |
| Paginering: | Jaargang 25 (2009) nr. 6 pagina's 500-503 |
| Jaar: |
2009 |
| Inhoud: |
Aim. To show that CHI3L2 activates the extracellular signal regulated kinase (ERK1/ERK2) mediated cascade similarly to the homologous CHI3L1 protein. Methods. The involvement of CHI3L2 in ERK1/ERK2 phosphorylation was evaluated by Western blotting with either polyclonal anti-ERK1/ERK2 or monoclonal anti- phospho-ERK1/ERK2 antibodies. Results. The checking of CHI3L2 possibility to initiate MAPK cascade showed the phosphorylation of ERK1/ERK2 in HEK293 after addition of CHI3L2 to DMEM. Conclusions. Chitinase-like protein CHI3L2 activates phosphorylation of ERK1/ERK2 in human embryonic kidney cells (HEK293) and thus initiates the MAP kinase signaling cascade which may lead to increased cell proliferation or differentiation. |
| Uitgever: |
Institute of molecular biology and genetics, National Academy of Sciences of Ukraine (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 11 van 11 gevonden artikelen
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