The histological effects of mixed diet containing Pausinystalia yohimbe ground stem bark on the kidney of adult Wistar rats (Rattus norvegicus)
Titel:
The histological effects of mixed diet containing Pausinystalia yohimbe ground stem bark on the kidney of adult Wistar rats (Rattus norvegicus)
Auteur:
Andrew O Eweka
Verschenen in:
Biology and medicine
Paginering:
Jaargang 2 (2010) nr. 1 pagina's 30-36
Jaar:
2010
Inhoud:
The effect of yohimbine, used as an aphrodisiac and for the treatment of erectile dysfunction in males on the kidneysof adult Wistar rat was investigated. Both adult male and female Wistar rats (n=30), average weight of 190g, wererandomly assigned into three treatments (n=24) and control (n=6) groups; labeled A (n=8), B (n=8), C (n=8) and D,control (n=6) groups respectively and were administered with ground stem bark of Pausinystalia yohimbe in variousamounts; Group A: 30g, Group B: 50g and Group C: 70g mixed with equal amount of feeds (550grams/day ofgrowers’ mash) for a period of 14 days. The control rats received equal amount of the growers’ mash without groundstem bark of Pausinystalia yohimbe added. The growers’ mash was obtained from Edo Feeds and Flour Mill Ltd,Ewu, Edo State and the rats were given water liberally. The rats were sacrificed on day fifteen of the experiment. Thekidneys were carefully dissected out and quickly fixed in 10% buffered formaldehyde for routine histologicalprocedures. The histological findings in the treated groups showed distortion of the renal cortical structures,vacuolations appearing in the stroma and some degree of cellular necrosis, with degenerative and atrophic changesas compared to the control group. These findings indicate that yohimbine may have some deleterious effects on thekidneys of adult Wistar rats at varied doses. It is recommended that further studies aimed at corroborating thesefindings be carried out.
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