The effects of sildenafil citrate on the superior colliculus of adult Wistar rats (Rattus norvegicus) - a histological study
Titel:
The effects of sildenafil citrate on the superior colliculus of adult Wistar rats (Rattus norvegicus) - a histological study
Auteur:
Andrew O Eweka
Verschenen in:
Biology and medicine
Paginering:
Jaargang 2 (2010) nr. 1 pagina's 24-29
Jaar:
2010
Inhoud:
The histological effect of oral administration of sildenafil citrate (Viagra), commonly used as an aphrodisiac and forthe treatment of erectile dysfunction on one of the visual relay centres namely the superior colliculus (SC) of adultWistar rat was carefully studied. The rats of both sexes (n=24), average weight of 202g were randomly assigned intothree treatment (n=18) and control (n=6) groups. The rats in the treatment groups ‘A’, ‘B’ and ‘C’ receivedrespectively, 0.25mg/kg, 0.70mg/kg and 1.43mg/kg body weight of sildenafil citrate base dissolved in distilled waterdaily for 30 days, through orogastric feeding tube, while that of the control group D, received equal volume of distilledwater daily during the period of the experiment. The rats were fed with growers’ mash obtained from Edo Feeds andFlour Mill Ltd, Ewu, Edo State, Nigeria and were given water liberally. The rats were sacrificed on day thirty-one ofthe experiment. The Superior colliculus was carefully dissected out and quickly fixed in 10% formal saline forhistological studies. The histological findings after H&E method indicated that the treated section of the Superiorcolliculus showed some varying degree of cell clustering, cellular hypertrophy, and intercellular vacuolationsappearing in the stroma of the superior colliculus. Varying dosage and long administration of sildenafil citrate mayhave some deleterious effects on the neurons of the intracranial visual relay centre and this may probably have someadverse effects on visual sensibilities by its deleterious effects on the cells of the superior colliculus of adult Wistarrats. It is therefore recommended that further studies aimed at corroborating these observations be carried out.
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