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| Titel: |
Role of sonic hedgehog signaling pathway in neuroblastoma development |
| Auteur: |
Mehdi Hayat Shahi |
| Verschenen in: |
Biology and medicine |
| Paginering: | Jaargang 1 (2009) nr. 4 pagina's Rev2 |
| Jaar: |
2009 |
| Inhoud: |
Malignant transformation of normal cells is a complex and accumulative process. Understanding this event givesinsight into mechanisms of developmental biology and physical interaction of cellular machinery with surroundingambient factors. However, the trend of embryonic malignancy is not interactive with ambient factors, rather a cause ofderegulations of internal developmental process. In this review, we have attempted to explore the possibility of sonichedgehog role in the development of neuroblastoma tumour. It is the major extra cranial tumour and develops in veryearly stage of childhood. Sonic hedgehog signaling is very well studied in another major childhood tumour i.e.medulloblastoma that contributes 20-25% of childhood tumours, and 1/4th of medulloblastoma is due of abnormality inthe Shh signaling pathway. Therefore, we would consider whether Shh could also contribute to the development ofneuroblastoma. Although scientists are coming up with role of Shh in the neuroblastoma, the sonic hedgehogsignaling is very much a promising pathway because of its multi-dimensional role not only in CNS development butalso in organogenesis and other major tumour development. |
| Uitgever: |
E Business Navigators (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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