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| Titel: |
Does intrinsic immune defect against common microbial pathogens play an important role in arthritic manifestation? |
| Auteur: |
S Subramanian D Subramanian |
| Verschenen in: |
Biology and medicine |
| Paginering: | Jaargang 1 (2009) nr. 3 pagina's Rev1 |
| Jaar: |
2009 |
| Inhoud: |
The autoimmune diseases are characterized by inflammation and resulting degradation of macromolecules ofspecific foci. Etiopathogenesis of arthritis is still unclear. In recent times many studies have been published,giving satisfactory explanation of infection and defective immune mechanisms for arthritic etio-pathogenesis.Understanding etio-pathogenesis is the most important and fundamental aspect of any particular problem. Manyhave given their different views on the above to educate the society. Out of these views, very few clear viewswere brought to the notice on immune dysfunction to common microbial infections. Convincingly, the above mayhave a strong connection to the disorder. Generally, it is thought that common microbial infections cause knownproblems but in unforeseen situation the dysregulation of immune function may also have acceptable reasonbehind the etio-pathogenesis. Vice-versa, defective immune functions like defective B cell function, defective BCell Receptor signaling mechanism, dysregulated cytokine function, auto-antibodies’ cross reactivity to selfantigens, inappropriate complement cascade events and defective apoptosis are few privileged environmentswhich are discussed here for possible explanation of etiology of rheumatoid arthritis. This review deals withinfection connection and defective immune mechanism of rheumatoid manifestation for further betterunderstanding of etiopathogenesis. |
| Uitgever: |
E Business Navigators (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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