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Details for article 7 of 11 found articles
| Title: |
Pro- and Anti-inflammatory Reactions in Brain-dead Organ Donors |
| Author: |
J. Kaden G. May C. Wesslau M. Marzinzig D. Abendroth |
| Appeared in: |
Transplantationsmedizin |
| Paging: | Volume 20 (2008) nr. 1 pages 32-38 |
| Year: |
2008 |
| Contents: |
Inflammations, tissue injuries, hypoxies and infections cause an acute phase reaction characterized by production and release of certain cytokines and proteins. This initial immunoactivation is counterregulated by immunosuppressive acting metabolites of tryptophan via activation of the Indoleamine 2,3-dioxygenase. It should be proven whether this immunoregulatory mechanism functioning in live organisms is also being active after brain death in prospective organ donors. Following parameters were determined to characterize immunoreactions in brain dead donors: Interleukin-6 (IL-6), Interleukin-2-receptor (IL-2R), C-reactive protein (CRP), Lipopolysaccharide-binding protein (LBP), Myeloid-related protein 8/14 (MRP8/14), and kynurenine as indicator of the Indoleamine 2,3-dioxygenase activity. Immediately prior to explantation (laparascopy) all acute phase reactants were significantly increased in comparison to normal values (mean values: normal versus donors; IL-6: <3,1 vs 389 pg/ml, IL-2R: 267 vs 966 U/ml; CRP: <5 vs 87 µg/ml; LBP: 8,6 vs 32,6 µg/ml; MRP8/14: 6,08 vs 45,0 µg/ml). Also the antiinflammatory acting kynurenine level was doubled in comparision to normal (2,51 vs 5,47 nmol/ml; p < 0,05). In order to characterize the dynamic process of these changes, elevated concentrations were compared with respect to the duration of treatment on the ward. Both IL-6 and CRP levels showed a comparable course of increasing concentrations with a peak on day 3. Thereafter (days 4 and >4) lower concentrations were again measured. In contrast the kynurenine levels rose permanently in relation to the duration of treatment. This counter-rotating behaviour of pro- and antiinflammatory reactants shows functioning regulatory mechanisms of innate immunity also in brain-dead organ donors. |
| Publisher: |
Pabst Science Publishers |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 7 of 11 found articles
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