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| Titel: |
Serum Levels of Myeloid-Related Protein 8/14 (MRP8/14): Dynamics and Diagnostic Relevance after Kidney Transplantation |
| Auteur: |
J. Kaden G. May V. Strobelt S. Mauracher A. Zecher C. Wesslau |
| Verschenen in: |
Transplantationsmedizin |
| Paginering: | Jaargang 15 (2003) nr. 1 pagina's 31-39 |
| Jaar: |
2003 |
| Inhoud: |
In a total of 723 sera from 52 kidney graft recipients and 23 organ donors the serum concentrations of MRP8/14 were retrospectively measured by an enzyme immunoassay in one run. The aim of this study was to find out quantitative changes of the MRP8/14 serum levels in connection with characterized events after kidney transplantation (KTx). In the pre-KTx sera tested the mean MRP8/14 level was 6.7 ± 3.5 µg/ml (reference value, 6.08 ± 2.22 µg/ml; upper normal level [ x + 2s] , 10.96 µg/ml). In 7 out of 52 recipients without intraoperative ATG prophylaxis the MRP8/14 level rose within the reference range to 10.2 ± 6.2 at the first post-KTx day. In contrast, the intraoperative T cell depletion by means of antilymphocytic antibodies caused a significant increase of the MRP8/14 level to 21.2 ± 12.5 µg/ml. In recipients with immediate (n=14) or delayed (n=11) graft function without any other complications all post-KTx values - except the post-KTx peak - were within the reference range. In 10 prednisolone-sensitive and 14 prednisolone-resistant rejection episodes no diagnostically usable changes of the MRP8/14 levels could be found except in one antibody-mediated accelerated rejection. Also, in 6 recipients with cytomegalovirus infection, the detection of pp65 positive peripheral blood cells was not associated with alterations of the MRP8/14 serum level. In contrast, significant elevations of the MRP8/14 levels were found in gram-positive bacteremia as well as in superinfected (CMV, soor) pneumocystis carinii pneumonias. In most cases the changes of MRP8/14 levels were comparable with those described for the lipopolysaccharide-binding protein, but in simultaneous determinations no correlation (R2=0.067) could be found between the concentrations of both proteins at the same day. In contrast, the C-reactive protein rose in all kinds of inflammatory events, although to very different levels. |
| Uitgever: |
Pabst Science Publishers |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 9 van 9 gevonden artikelen
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