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| Titel: |
Cyclosporine C2-Monitoring for Optimisation of Immunosuppression in Renal Transplantation – Recommendations According to First Experience in German Centers |
| Auteur: |
B. Nashan V. W. Armstrong K. Budde L. Fricke U. Heemann R. Lück E. Röthele E. H. Scheuermann B. Suwelack |
| Verschenen in: |
Transplantationsmedizin |
| Paginering: | Jaargang 15 (2003) nr. 1 pagina's 15-24 |
| Jaar: |
2003 |
| Inhoud: |
Cyclosporine has been worldwide the mainstay of immunosuppressive therapy in organ transplant recipients for prevention of acute and chronic rejection in the past two decades. The dosage is usually adjusted on the basis of whole blood through level (C0 level) monitoring. However, it became evident after the development of the microemulsion formulation that a better correlation of the drug level taken two hours after medication (C2 level) reflects the improved bioavailability of Cyclosporine much better. Interpatient variability in absorption as well as improved identification of over- or underdosing offer the opportunity of an individualized monitoring in order to improve drug exposure. C2 levels published in the international literature mainly represent North-American clinical experience and practice with traditionally higher cyclosporine dosing in comparison to Europe. Since C2-Monitoring has been introduced in german centers since last year, there was anonymous agreement for a consensus meeting to discuss recommendations for cyclosporine monitoring, better reflecting the German practice. The presented consensus focuses on immunosuppression in renal transplantation. |
| Uitgever: |
Pabst Science Publishers |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 3 van 9 gevonden artikelen
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