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Details van artikel 2 van 9 gevonden artikelen
| Titel: |
B-Lymphocyte/Plasma Cell Accumulation and Expression of the B-Cell Specific Chemokine MIP-3a /CCR-6 in Acute Liver Allograft Rejection |
| Auteur: |
M. G. Krukemeyer L. Morawietz M. Harren C. Radke P. Gratze P. Neuhaus V. Krenn |
| Verschenen in: |
Transplantationsmedizin |
| Paginering: | Jaargang 15 (2003) nr. 1 pagina's 40-46 |
| Jaar: |
2003 |
| Inhoud: |
Although humoral antibody mediated mechanisms play a role in liver allograft rejection, no data exist concerning B-lymphocytes and plasma cells. The aim of this study was to analyse whether 1) B-lymphocytes and plasma cells are present in biopsies of acute graft rejection. 2) B-lymphocytes and plasma cells are expanded by local proliferation or immigration and 3) whether the B-cell specific chemokine MIP-3a /CCR-6 is expressed in liver tissue. Biopsies of 20 patients with acute graft rejection (AR-biopsies) were analysed by immunohistochemistry (CD20, CD38, CD 138, CD 20/Ki67, MIP-3a , CCR-6) and by RT-PCR (MIP-3a ,CCR-6). In all biopsies with acute graft rejection (RAI-Score 1-9) CD20+ B-lymphocytes and CD38+/138+ plasma cells could be detected, MIP-3a or CCR-6 expression could be observed in all AR-biopsies on granulocytes and mononuclear cells, which was confirmed by RT-PCR. In comparison of AR-biopsies with AO-biopsies (biopsies taken before transplantation) there was a significant increase in the quantity of CD20+ B-lymphocytes (p=0,002) and CD38+/CD138+ plasma cells (p=0,022) whereas no significant differences could be observed in the quantity of proliferating B-lymphocytes (p=0,262). These data suggest that local B-lymphocyte/plasma cell expansion occurs not by proliferation but by immigration. The local expression of MIP-3a and CCR-6 indicates that this chemokine is involved in B-cell accumulation during acute graft rejection and suggests a local, antibody mediated pathomechanism in acute liver allograft rejection. |
| Uitgever: |
Pabst Science Publishers |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 2 van 9 gevonden artikelen
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