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Details for article 5 of 13 found articles
| Title: |
Determination of cytotoxicity of nephrotoxins on murine and human kidney cell lines |
| Author: |
Park, Eun-Kee Mak, Sally K. Kultz, Dietmar Hammock, Bruce D. |
| Appeared in: |
Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes |
| Paging: | Volume 43 (2008) nr. 1 pages 71-74 |
| Year: |
2008-01 |
| Contents: |
The present study investigates renal inner medullary collecting duct (mIMCD3) cells and human embryonic kidney cells (HEK293) for evaluation of cytotoxicity of nephrotoxic compounds. The 24 h LC50 values for cisplatin, paraquat and ibuprofen in mIMCD3 cells were 135, 155 and 3600 μM, respectively. The 24 h LC50 values for paraquat and ibuprofen in HEK293 cells were 180 and 1000 μM, respectively. Effects of hyperosmolality on cytotoxicity of paraquat were additive in mIMCD3 cells. These data demonstrate that renal hyperosmolality has an additive effect on cytoxicity of paraquat. |
| Publisher: |
Taylor & Francis |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 5 of 13 found articles
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