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| Titel: |
Synthesis of conjugates of 3-hydroxy- and 3-phenoxybenzoic acids |
| Auteur: |
Paquet, A. Akhtar, M. H. Johns, M. |
| Verschenen in: |
Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes |
| Paginering: | Jaargang 28 (1993) nr. 2 pagina's 171-191 |
| Jaar: |
1993-04 |
| Inhoud: |
Conjugates of 3-hydroxy- 3-methoxy- and the 3-phenoxybenzoic acids, (the major metabolites of many pyrethroid pesticides) with acetyl- and benzoylornithine were synthesized by means of succinimidyl ester method or N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide mediated couplings. Methyl esters were removed by alkaline hydrolysis. Hydrogenolysis of N2-substituted N5-benzyloxy-carbonylornithine methyl ester derivatives gave corresponding 3-acylaminopiperidones. The glycylvaline methyl esters were prepared by stepwise lengthening starting with valine methyl ester using N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide as coupling reagent to introduce N-t-butyloxycarbonylglycine followed by coupling with the appropriate acid after the N-t-butyloxycarbonyl group removal. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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