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Details for article 5 of 7 found articles
| Title: |
Synthesis of conjugates of 3-hydroxy- and 3-phenoxybenzoic acids |
| Author: |
Paquet, A. Akhtar, M. H. Johns, M. |
| Appeared in: |
Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes |
| Paging: | Volume 28 (1993) nr. 2 pages 171-191 |
| Year: |
1993-04 |
| Contents: |
Conjugates of 3-hydroxy- 3-methoxy- and the 3-phenoxybenzoic acids, (the major metabolites of many pyrethroid pesticides) with acetyl- and benzoylornithine were synthesized by means of succinimidyl ester method or N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide mediated couplings. Methyl esters were removed by alkaline hydrolysis. Hydrogenolysis of N2-substituted N5-benzyloxy-carbonylornithine methyl ester derivatives gave corresponding 3-acylaminopiperidones. The glycylvaline methyl esters were prepared by stepwise lengthening starting with valine methyl ester using N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide as coupling reagent to introduce N-t-butyloxycarbonylglycine followed by coupling with the appropriate acid after the N-t-butyloxycarbonyl group removal. |
| Publisher: |
Taylor & Francis |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 5 of 7 found articles
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