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Details van artikel 2 van 9 gevonden artikelen
| Titel: |
Delayed neuropathy in sheep by the phosphonothioate insecticide cyanofenphos |
| Auteur: |
El-Sebae, A. H. Soliman, S. A. Ahmed, Nabila S. |
| Verschenen in: |
Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes |
| Paginering: | Jaargang 14 (1979) nr. 3 pagina's 247-263 |
| Jaar: |
1979 |
| Inhoud: |
Cyanofenphos (surecide)(R), 25% E.C., O-ethyl O-(4-cyanophenyl) phenylphosphonothioate, was orally administered to one year old lambs at sublethal doses of 1 mg, 2 mg and 4 mg active ingredient kg-l day-1for time intervals 60, 45 and 30 days respectively. Irreversible paralytic ataxia symptoms of delayed neuropathy appeared at about 80, 50 and 30 days respectively. In weekly blood samples, AChE (acetyl-choline-sterase) and MAO (monoamine oxidase) activities were inhibited depending upon level of dosing and time interval. However no significant correlation was found between the extent of plasma AChE and MAO inhibition and the onset of ataxia symptoms. In brain samples from ataxiated animals, AChE, MAO and NTE (neurotoxic esterase) activities were assayed simultaneously with untreated animal. Direct correlation was shown between in vivo NTE inhibition and the occurence of delayed neuropathy. Cyanofenphos is the third compound of the phenyl phosphonothioate type on the market showing delayed neuropathy together with Leptophos and EPN. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 2 van 9 gevonden artikelen
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