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| Titel: |
Carcinogenicity of hexachlorocyclohexane (BHC) in pure inbred swiss mice |
| Auteur: |
Kashyap, S. K. Nigam, S. K. Gupta, R. C. Karnik, A. B. Chatterjee, S. K. |
| Verschenen in: |
Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes |
| Paginering: | Jaargang 14 (1979) nr. 3 pagina's 305-318 |
| Jaar: |
1979 |
| Inhoud: |
Inbxed Swiss nice were treated with technical BHC (1) orally with the diet or by intubation and (2) by skin painting. The total duration of the experiment was 80 weeks. There was no difference in body growth and mortality between the experimental and control groups. Symptoms of intoxication in the form of convulsions and tendency of circling in one direction with drooping ears were observed alongwith corneal opacity 40 weeks after the experiment. Oral BHC treatment resulted in a significant increase in the incidence of liver tumours and tumours of lymphoreticular tissue. Males and females were equally susceptibie. Skin painting of mice did not significantly increase the incidence of tumour. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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