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| Titel: |
Synthesis and characterization of polyanhydride for local BCNU delivery carriers |
| Auteur: |
Moon Suk Kim Kwang Su Seo Ha Soo Seong Sun Hang Cho Hai Bang Lee Keum Duck Hong Sun Kyung Kim Gilson Khang |
| Verschenen in: |
Bio-medical materials and engineering |
| Paginering: | Jaargang 15 (2005) nr. 3 pagina's 229-238 |
| Jaar: |
2005-05-23 |
| Inhoud: |
p-Carboxyphenoxy propane (CPP) prepolymer consisting of 4 units and sebacic acid (SA) prepolymer consisting of about 10 units were synthesized by reacting CPP and SA in the presence of excess acetic anhydride, respectively. Polyanhydride, poly(CPP-SA) copolymers were copolymerized by a melt polycondensation process with a mixture of CPP and SA prepolymer. Copolymers of average molecular weight up to 110,000 g/mol were achieved. The crystallinity of poly(CPP-SA) copolymers was decreased by the addition of the CPP homopolymer segment to SA homopolymer. Poly(CPP-SA) copolymers gradually degraded for period of 10 days. No large difference of weight loss observed according to molecular weight variation of poly(CPP-SA) copolymers. BCNU release from wafers fabricated by poly(CPP-SA) showed a sustained release pattern with no initial burst and delay of drug release. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 9 van 10 gevonden artikelen
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