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                                       Details for article 9 of 10 found articles
 
 
  Synthesis and characterization of polyanhydride for local BCNU delivery carriers
 
 
Title: Synthesis and characterization of polyanhydride for local BCNU delivery carriers
Author: Moon Suk Kim
Kwang Su Seo
Ha Soo Seong
Sun Hang Cho
Hai Bang Lee
Keum Duck Hong
Sun Kyung Kim
Gilson Khang
Appeared in: Bio-medical materials and engineering
Paging: Volume 15 (2005) nr. 3 pages 229-238
Year: 2005-05-23
Contents: p-Carboxyphenoxy propane (CPP) prepolymer consisting of 4 units and sebacic acid (SA) prepolymer consisting of about 10 units were synthesized by reacting CPP and SA in the presence of excess acetic anhydride, respectively. Polyanhydride, poly(CPP-SA) copolymers were copolymerized by a melt polycondensation process with a mixture of CPP and SA prepolymer. Copolymers of average molecular weight up to 110,000 g/mol were achieved. The crystallinity of poly(CPP-SA) copolymers was decreased by the addition of the CPP homopolymer segment to SA homopolymer. Poly(CPP-SA) copolymers gradually degraded for period of 10 days. No large difference of weight loss observed according to molecular weight variation of poly(CPP-SA) copolymers. BCNU release from wafers fabricated by poly(CPP-SA) showed a sustained release pattern with no initial burst and delay of drug release.
Publisher: IOS Press
Source file: Elektronische Wetenschappelijke Tijdschriften
 
 

                             Details for article 9 of 10 found articles
 
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