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| Titel: |
Three-dimensional model of bone marrow stromal cell culture |
| Auteur: |
Maciej Januszewski Zbigniew Dąbrowski Maria Adamus Tadeusz Niedźwiedzki |
| Verschenen in: |
Bio-medical materials and engineering |
| Paginering: | Jaargang 13 (2003) nr. 1 pagina's 1-9 |
| Jaar: |
2003-03-27 |
| Inhoud: |
In a hematopoietic microenvironment in vivo, spatial organisation of hematopoiesis is possible due to the existence of a three-dimensional framework, the main part of which is formed by a branching population of stromal cells. Most of the previous in vitro studies, concerning long-term bone marrow cultures, were based on a previously prepared, flat adherent layer of stromal cells. There are only few reports concerning the three-dimensional growth pattern of the bone marrow stroma. In the present study we used a new three-dimensional model of the stromal cell culture. The framework for the cultured stromal cells was a structure of a nonliving trabecular bone (Unilab Surgibone). After a period of about four weeks the stromal cells created a spatial network which filled the intertrabecular spaces of the spongy bone. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 9 van 9 gevonden artikelen
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