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| Titel: |
Photodynamic therapies: Principles and present medical applications |
| Auteur: |
Silva, João N. Filipe, Paulo Morlière, Patrice Mazière, Jean-Claude Freitas, João P. Cirne de Castro, José L. Santus, René |
| Verschenen in: |
Bio-medical materials and engineering |
| Paginering: | Jaargang 16 (2006) nr. supplement-4 pagina's S147-S154 |
| Jaar: |
2006-07-13 |
| Inhoud: |
Photodynamic therapy (PDT) by porphyrins and related tetrapyrrole derivatives is an emerging new treatment modality of tumors of lung, eosophagus and skin and of age-related macular degeneration. Phase III clinical trials for other applications such as re-stenosis after angioplasty are also underway. Under systemic conditions, the transport of porphyrin photosensitizers by serum low density lipoproteins and their specific delivery to tumor cells and vasculature is a determinant of treatment effectiveness. However, this effectiveness can be improved by increasing the selectivity of the photosensitizer uptake by tumors and by using photosensitizers absorbing light in the 660-800 nm range where tissues have the highest transmittance. Another treatment showing great promise is the PDT of skin cancers after topical application of the protoporphyrin IX precursor delta-aminolevulinic acid (or its ester forms). In all the cases, the photosensitizers should be rapidly excreted to avoid a long lasting skin photosensitivity. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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