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| Titel: |
Atypical antipsychotic agents for the schizophrenia prodrome: Not a clear first choice |
| Auteur: |
Kruszewski, Stefan P. Paczynski, Richard P. |
| Verschenen in: |
International journal of risk & safety in medicine |
| Paginering: | Jaargang 20 (2008) nr. 1-2 pagina's 37-44 |
| Jaar: |
2008-04-11 |
| Inhoud: |
Pharmacologic intervention at the earliest stages of suspected psychotic illness is an intuitively appealing concept and a logical extension of the current approach to many other diseases of the central nervous system. Atypical antipsychotic agents (ATAPs) seem to be a reasonable choice for early intervention because existing pre-clinical data suggest that they have pharmacologic properties which might confer ‘neuroprotection’. However, a critical analysis of the results of structured clinical investigations which have explored the use of ATAPs for new-onset psychotic symptoms raises safety concerns and does not support pre-medication in this setting as a preventive strategy. Caution in current practice is therefore appropriate, underscoring the need for much additional clinical research. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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