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Details van artikel 15 van 31 gevonden artikelen
| Titel: |
Integrins and cell signaling in chondrocytes |
| Auteur: |
Loeser, Richard F. |
| Verschenen in: |
Biorheology |
| Paginering: | Jaargang 39 (2002) nr. 1-2 pagina's 119-124 |
| Jaar: |
2002-07-11 |
| Inhoud: |
Integrins are adhesion receptor heterodimers that transmit information from the extracellular matrix (ECM) to the cell through activation of cell signaling pathways. Chondrocytes express several members of the integrin family including α5β1 which is the primary chondrocyte receptor for fibronectin. Cell signaling mediated through integrins regulates several chondrocyte functions including differentiation, matrix remodeling, responses to mechanical stimulation and cell survival. Integrinmediated activation of members of the mitogen-activated protein kinase family likely plays a key role in transmitting signals regulating chondrocyte gene expression. Upstream mediators of mitogen-activated protein kinase (MAP kinase) activation include focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (pyk2) which are both expressed by chondrocytes. A better understanding of chondrocyte integrin signaling is needed to define the mechanisms by which the ECM regulates chondrocyte function. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 15 van 31 gevonden artikelen
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