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Details van artikel 81 van 101 gevonden artikelen
| Titel: |
The Effects of Remote Ischemic Preconditioning On Pulmonary Ischemia-Reperfusion Injury on a Rat Model |
| Auteur: |
Hasan Akkoç İlker Kelle Ebru Kale Nihal Kılınç |
| Verschenen in: |
Dicle medical journal |
| Paginering: | Jaargang 35 (2008) nr. 3 pagina's 159-166 |
| Jaar: |
2008 |
| Inhoud: |
Ischemia and reperfusion of a tissue or a viscera can induce a protectiveeffect such as development of preconditioning on the other tissues which haveanother source of arterial blood flow. This mechanism of action is known asremote ischemic preconditioning. The objective of this study was to investigatethe effects of preconditioning formed by coronary artery occlusion over thepulmonary ischemia and ischemia-reperfusion injury in a rat model. We usedadult, 30 Sprague-Dawley rats (n=6). There were five experimental groups;Group 1: Control (Sham operated), Group 2: Pulmonary ischemia (30 min),Group 3: Pulmonary ischemia (30 min)-reperfusion (60 min), Group 4:Cardiac ischemic preconditioning followed by pulmonary ischemia (30 min),Group 5: Cardiac ischemic preconditioning followed by pulmonary ischemia(30 min)-reperfusion (60 min). In the end of experimental procedures,histopathological assessments were performed on lung tissue specimens andmalonyldialdehyde and purine nucleotide levels of lung tissue were measuredby High Performance Liquid Chromatography. As a conclusion, cardiacischemic preconditioning can induce a protective effect over the pulmonaryischemia and ischemia-reperfusion injury. It can be suggested that theprotective effect of remote ischemic preconditioning is related with adenosine. |
| Uitgever: |
Dicle University Medical School (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 81 van 101 gevonden artikelen
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