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| Titel: |
The Effects of Histamine H3 Receptors on Contractile Responses on Rat Gastric Fundus |
| Auteur: |
Aşkın Hekimoğlu Ramazan Çiçek |
| Verschenen in: |
Dicle medical journal |
| Paginering: | Jaargang 33 (2006) nr. 3 pagina's 127-133 |
| Jaar: |
2006 |
| Inhoud: |
The aim of this study is to determine the effects of histamine receptors on the gastrointestinal system smooth muscle contractions and the role of histamine H3 receptors on these effects. İsolated rat gastric fundus preparations were hanged on isolated organ bath and histamine receptor agonist and anthagonists were added to the bath solution and the electrical field stimulation-induced contractile responses were evaluated. In our study groups after blocking one of the histamine receptors H1, H2,H3; contractile responses were observed. Then, other two receptors were blocked one by one or combination of them to observe the changes on the contractile responses given to the electrical stimulation .To blocke histamine receptors pyrilamine (10-6м) as H1 receptor blocker, famotidine (10-6м) as H2 receptor blocker and thioperamide (10-5м) as H3 receptor blocker and various combination of them were used. All groups were treated with H3 receptor anthagonist thioperamide (10-5м) and agonist (R)-α-methylhistamine (R)MHA on 10-8, 10-7, 10-6 ve 10-5 molar concentrations cumulatively to observe its mediator effects on contractile responses. We suggested that (R)-α-methylhistamine mediates the inhibition on the contractile effects of rat gastric fundus. This conclusion was supported by these findings: a) the selective agonists (R)MHA caused a dumping of the contractile effect of acetylcholine; b) the effect of (R)MHA was prevented by the selective H3 receptor antagonist thioperamide. |
| Uitgever: |
Dicle University Medical School (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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