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Details van artikel 29 van 180 gevonden artikelen
| Titel: |
Drug Release Kinetics of Spray-Dried Chitosan Microspheres |
| Auteur: |
Liu, Chengsheng Desai, Kashappa Goud H. Tang, Xuexi Chen, Xiguang |
| Verschenen in: |
Drying technology |
| Paginering: | Jaargang 24 (2006) nr. 6 pagina's 769-776 |
| Jaar: |
2006-07-01 |
| Inhoud: |
The aim of this article was to investigate the drug release kinetics of spray-dried chitosan microspheres using various kinetic models. The mean particle size and encapsulation efficiency of cross-linked chitosan microspheres was between 3.8 and 4.2 μm and 96.3 and 98.7%, respectively. Spray-dried chitosan microspheres were spherical in shape with smooth surface. The surface morphology of spray-dried chitosan microspheres was affected by the crystallinity of the loaded drug and cross-linking agent. The release data of the spray-dried chitosan microspheres were treated with zero-order, first-order, Higuchi, Korsmeyer, and Kopcha kinetic models and best fit was observed with Higuchi model, indicating the release of drug from spray-dried chitosan microspheres followed Fick's law of diffusion. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 29 van 180 gevonden artikelen
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