Digitale Bibliotheek
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                             130 gevonden resultaten
nr titel auteur tijdschrift jaar jaarg. afl. pagina('s) type
1 Abnormal regulation of membrane-less organelles contributes to profilin1-associated ALS Ma, Guoqiang

301 7 p.
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2 Acyl chains stabilize the acylated domain and determine the receptor-mediated interaction of the Bordetella adenylate cyclase toxin with cell membrane Espinosa-Vinals, Carlos

301 7 p.
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3 A distinct class of ferredoxin:NADP+ oxidoreductase enzymes driving thermophilic ethanol production Huang, Shu

301 7 p.
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4 A glycine at position 105 leads to clavulanic acid and avibactam resistance in class A β-lactamases Radojković, Marko

301 7 p.
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5 Analysis of chondroitin degradation by components of a Bacteroides caccae polysaccharide utilization locus Alvarez, Bernadette

301 7 p.
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6 Ancestral evolution of oxidase activity in a class of (S)-nicotine and (S)-6-hydroxynicotine-degrading flavoenzymes Zhang, Zhiyao

301 7 p.
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7 A novel compound DBZ alleviates chronic inflammatory pain and anxiety-like behaviors by targeting the JAK2-STAT3 signaling pathway Sun, Bao

301 7 p.
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8 A repertoire of visible light–sensitive opsins in the deep-sea hydrothermal vent shrimp Rimicaris hybisae Nagata, Yuya

301 7 p.
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9 Armless hairpin-like tRNAs in Romanomermis culicivorax: Evolutionary adaptation of a mitochondrial elongation factor EF-Tu Bernier, Dorian

301 7 p.
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10 ARRDC3 tyrosine phosphorylation functions as a switch to control c-Src versus WWP2 interactions and distinct scaffolding functions Caplan, Mika

301 7 p.
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11 ATPase-dependent duplex nucleic acid unwinding by SARS-CoV-2 nsP13 relies on facile binding and translocation along single-stranded nucleic acid Park, Jinwoo

301 7 p.
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12 A versatile fluorescence polarization-based deubiquitination assay using an isopeptide bond substrate mimetic (IsoMim) Zhang, Jiatong

301 7 p.
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13 Bacterial genome-encoded ParMs Ali, Samson

301 7 p.
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14 BET bromodomain inhibitors attenuate transcription of a subset of IL-1-induced NF-κB targets that promote inflammation in β-cells Nord, Joshua A.

301 7 p.
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15 Biochemical and structural characterization of a GNAT superfamily protein acetyltransferase from Helicobacter pylori Dadireddy, Venkatareddy

301 7 p.
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16 Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraints Alexander, Patrick

301 7 p.
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17 Biosynthesis of fatty aldehydes and alcohols in the eye and their role in meibogenesis Yuksel, Seher

301 7 p.
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18 Calcium triggers calmodulin degradation to induce EGF receptor instability and overcome non-small cell lung cancer resistance to tyrosine kinase inhibitors Li, Luping

301 7 p.
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19 Characterization of ADAMTS9 proteoglycanase activity: Comparison with ADAMTS1, ADAMTS4, and ADAMTS5 Martin, Daniel R.

301 7 p.
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20 Characterization of Caenorhabditis elegans sphingomyelin synthases through heterologous expression Guzman, Gaelen

301 7 p.
artikel
21 Characterization of H3K4me3 in mouse oocytes at the metaphase II stage Takasu, Atsushi

301 7 p.
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22 Characterization of the activity of KTX-1001, a small molecule inhibitor of multiple myeloma SET domain using surface plasmon resonance Lewis, Chad A.

301 7 p.
artikel
23 Characterizing the excision of 7,8-dihydro-8-oxoadenine by thymine DNA glycosylase Servius, Hardler W.

301 7 p.
artikel
24 Circular RNA-OGDH promotes PANoptosis in diabetic cardiomyopathy: A novel mechanistic insight Guan, Jingyue

301 7 p.
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25 Colchicine inhibits vascular calcification by suppressing inflammasome activation through the enhancement of the Sirt2-PP2Ac signaling pathway Yang, Shu

301 7 p.
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26 Complete biosynthesis of the fungal alkaloid zinnimidine: Biochemical insights into the isoindolinone core formation Luo, Ling

301 7 p.
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27 Cover
301 7 p.
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28 CpgD is a phosphoglycerate cytidylyltransferase required for ceramide diphosphoglycerate synthesis Dhakephalkar, Tanisha

301 7 p.
artikel
29 Crosstalk between iron and flavins in the opportunistic fungal pathogen Candida albicans David, Marika S.

301 7 p.
artikel
30 Crustacean methyl farnesoate–binding protein is an insect juvenile hormone–binding protein homolog that inhibits molting Yang, Hao

301 7 p.
artikel
31 Cryo-EM structures reveal the PP2A–B55α and Eya3 interaction that can be disrupted by a peptide inhibitor Shi, Shasha

301 7 p.
artikel
32 Cytochrome P450BM-3 and P450 11A1 retain Compound I (FeO3+) chemistry with electrophilic substrates poised for Compound 0 (Fe3+O2 −) reactions McCarty, Kevin D.

301 7 p.
artikel
33 Differential activation of the inositol 5-phosphatase SHIP2 by EGF and insulin signaling pathways Damouni, Amir

301 7 p.
artikel
34 Dimerization of the BAR domain–containing protein FAM92A modulates lipid binding and interaction with CBY1 Xu, Xiaohan

301 7 p.
artikel
35 Efficient cell-free translation from diverse human cell types Ziegelmüller, Jana

301 7 p.
artikel
36 Endogenous formation of phosphatidylhomoserine in Escherichia coli through phosphatidylserine synthase Ng, Elise Zi Qi

301 7 p.
artikel
37 Endothelial protein C receptor and thrombomodulin facilitate protease-activated receptor 1 cleavage at Arginine-46 by thrombin and activated protein C Biswas, Indranil

301 7 p.
artikel
38 Estradiol (E2) concentration shapes the chromatin binding landscape of estrogen receptor alpha Han, Amy L.

301 7 p.
artikel
39 Evaluation of AlphaFold modeling for elucidation of nanobody–peptide epitope interactions Sachdev, Shivani

301 7 p.
artikel
40 FAK activity exacerbates disturbed flow-mediated atherosclerosis via VEGFR2-CBL-NF-κB signaling Murphy, James M.

301 7 p.
artikel
41 Fast peptide bond formation and release by the ribosomal large subunit Bao, Letian

301 7 p.
artikel
42 FHL2 facilitates LUSC growth and therapy resistance through PI3K/AKT/mTOR activation Zhang, Lingxian

301 7 p.
artikel
43 Functional genomics and structural insights into maize aldo-keto reductase-4 family: Stress metabolism and substrate specificity in embryos Morais de Sousa, Sylvia

301 7 p.
artikel
44 Functional insights into Plasmodium actin-depolymerizing factor interactions with phosphoinositides Lasiwa, Devaki

301 7 p.
artikel
45 Genetic deficiency of EXOSC10 ribonuclease disrupts spermatogenesis and male fertility in mice Yu, Junjie

301 7 p.
artikel
46 High-throughput epigenetic profiling immunoassays for accelerated disease research and clinical development Van den Ackerveken, Priscilla

301 7 p.
artikel
47 HIPK4 accelerates cutaneous squamous cell carcinoma progression by phosphorylating TAp63 and inhibiting EFEMP1 expression Guo, Ze

301 7 p.
artikel
48 5hmC enhances PARP trapping and restores PARP inhibitor sensitivity in chemoresistant BRCA1/2-deficient cells Kharat, Suhas S.

301 7 p.
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49 How short is too short for amyloid fibrils?: Molecular dynamics of oligomers of infectious prion core structures Artikis, Efrosini

301 7 p.
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50 HSD3B1 upregulation via LRH1 sustains estrogen receptor signaling and promotes endocrine resistance in breast cancer Li, Xiuxiu

301 7 p.
artikel
51 Humanin variants aggregate to produce different fibril morphologies Morris, Daniel L.

301 7 p.
artikel
52 Hypoxia-inducible factor-1 alpha modulates muscle growth and the molting process through its regulation of glycolysis in Neocaridina davidi Li, Ran

301 7 p.
artikel
53 Identification and characterization of mono- and bifunctional galactan synthases in the pediatric pathogen Kingella kingae Porsch, Eric A.

301 7 p.
artikel
54 Identification of substrates and sequence requirements for CARNMT1-mediated histidine methylation of C3H zinc fingers Małecki, Jędrzej M.

301 7 p.
artikel
55 Induction of the zinc finger transcription factor GATA2 promotes kidney inflammation-related gene expression Takai, Jun

301 7 p.
artikel
56 Inhibition of sulfotransferase SULT2B1 prevents obesity and insulin resistance by regulating energy expenditure and intestinal lipid absorption Wang, Jingyuan

301 7 p.
artikel
57 Interactome of FMRP-N-tat therapeutic unveils key interactions for cellular function in Fragile X neurons Leguay, Kévin

301 7 p.
artikel
58 In vivo pulse-chase in Caenorhabditis elegans reveals intestinal histone turnover changes upon starvation Borchers, Christopher

301 7 p.
artikel
59 Itraconazole and posaconazole, inhibitors of NPC1 sterol transport, act as pharmacological chaperones after washout Wang, Weixiang A.

301 7 p.
artikel
60 Live-cell imaging of DNA damage and cell cycle progression uncovers distinct responses during neural differentiation of hiPSCs Shimada, Mikio

301 7 p.
artikel
61 Long AKAP18 isoforms anchor ubiquitin specific proteinases and coordinate calcium reuptake at the sarcoplasmic reticulum Park, Taeyeop

301 7 p.
artikel
62 Lysophospholipid stereoisomers exert distinct GPR55-mediated functions via different Gα subunits Guy, Adam T.

301 7 p.
artikel
63 Machine learning–based multimodal radiomics and transcriptomics models for predicting radiotherapy sensitivity and prognosis in esophageal cancer Ye, Chengyu

301 7 p.
artikel
64 Mannose-modified hemocyanin enhances pathogen endocytosis by crustacean hemocytes Li, Jiaxi

301 7 p.
artikel
65 Map of the neuronal O-glycoproteome reveals driver functions in the regulated secretory pathway Madsen, Thomas D.

301 7 p.
artikel
66 Mechanisms of USP18 specificity toward ISG15 revealed by paralog sequence analysis comparison Bonacci, Thomas

301 7 p.
artikel
67 MicroRNA-129-5p-mediated translational repression of microglial ROCK1 leads to enhanced phagocytosis Dey, Rajib Kumar

301 7 p.
artikel
68 Mitochondrial tRNA processing defects reprogram mitochondrial and cellular homeostasis Zhu, Gao

301 7 p.
artikel
69 Modulation of cyanobacterial Photosystem I protein environment and spectral capacity in response to changes in electron flow pathways and photon flux Smolinski, Sharon L.

301 7 p.
artikel
70 Molecular basis for presentation of N-myristoylated peptides by the chicken YF1∗7.1 molecule Khandokar, Yogesh

301 7 p.
artikel
71 Molecular basis of acyl-CoA ester recognition by α-methylacyl-CoA racemase from Mycobacterium tuberculosis Mojanaga, Otsile O.

301 7 p.
artikel
72 Molecular consequences of SCA5 mutations in the spectrin-repeat domains of β-III-spectrin Denha, Sarah A.

301 7 p.
artikel
73 Molecular insights into chemotherapy resistance mediated by MLL-AF9 fusion gene in pediatric B-cell acute lymphoblastic leukemia Sang, Xu

301 7 p.
artikel
74 Molecular mechanism of antagonist recognition and regulation of the α1A-adrenoceptor Liu, Sisi

301 7 p.
artikel
75 M54 selectively stabilizes the circadian clock component of CRY1 and enhances the period of circadian rhythm at cellular level Gül, Zeynep Melis

301 7 p.
artikel
76 Multiple, redundant carboxylic acid transporters support mitochondrial metabolism in Plasmodium falciparum Rajaram, Krithika

301 7 p.
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77 Myristoylation of TMEM106B by NMT1/2 regulates TMEM106B trafficking and turnover Lacrampe, Alexander

301 7 p.
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78 Nanobodies targeting EGFR provide insight into conformations stabilized by glioblastoma mutations Watson, Sean M.

301 7 p.
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79 NDRG1 and its family members: More than just metastasis suppressor proteins and targets of thiosemicarbazones Azad, Mahan Gholam

301 7 p.
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80 Orthologues of the human protein histidine methyltransferase METTL9 display distinct substrate specificities Schroer, Lisa

301 7 p.
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81 Paracrine regulation of pancreatic cancer cell response to chemotherapy by GLI2–collagen I signaling Vera, Renzo E.

301 7 p.
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82 Perturbations in L-serine metabolism regulate protein quality control through the sensor of the retrograde response pathway R TG 2 in Saccharomyces cerevisiae Saxena, Kanika

301 7 p.
artikel
83 Phosphorylation of syntenin-1 by TBK1 promotes proliferation and migration of non-small cell lung cancer cells Gao, Lin

301 7 p.
artikel
84 PLK1-mediated PDHA1 phosphorylation drives mitochondrial dysfunction, mitophagy, and cancer progression in Cr(VI)-associated lung cancer Zhang, Qiongsi

301 7 p.
artikel
85 Post-transcriptional regulation of H19 by m6A reader proteins: H19 stability versus miR-675 biogenesis Jana, Samarjit

301 7 p.
artikel
86 Potential blocker of SARS-CoV entry and a narrow functionality of its spike protein motifs on Qubevirus platform Dzelamonyuy, Aristide

301 7 p.
artikel
87 Proton gradient controls the lateral rearrangement of inner membrane domains in response to membrane fluidizer stress in Mycobacterium smegmatis Prithviraj, Malavika

301 7 p.
artikel
88 Quantification profiles of enzyme activity, secretion, and psychosine levels of Krabbe disease galactosylceramidase missense variants Peng, Hui

301 7 p.
artikel
89 Rag GTPases control lysosomal acidification by regulating v-ATPase assembly in Drosophila Zhou, Ying

301 7 p.
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90 Regulation of NRF2 by stably associated phosphoinositides and small heat shock proteins in response to stress Chen, Changliang

301 7 p.
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91 Regulatory helix plays a key role in genetic ON–OFF switching for the 2′-deoxyguanosine-sensing mRNA element Chaudhury, Susmit Narayan

301 7 p.
artikel
92 Retraction: Induction of Hypoxia-inducible Factor 1 Activity by Muscarinic Acetylcholine Receptor Signaling Hirota, Kiichi

301 7 p.
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93 Retraction: Nitric Oxide Induces Hypoxia-inducible Factor 1 Activation That Is Dependent on MAPK and Phosphatidylinositol 3-Kinase Signaling Kasuno, Kenji

301 7 p.
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94 Secreted EMC10 inhibits muscle GLUT4 activity and glucose uptake in mice Jin, Shuoshuo

301 7 p.
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95 Select early growth response (Egr) isoforms augment hypoxia inducible factor 2 (HIF-2) regulation of erythropoietin (Epo) gene expression in mammals Nagati, Jason S.

301 7 p.
artikel
96 Single-subunit RNA polymerases, KpnP, Ro45Iw, and CD23823, with precise terminal synthesis Takatsuki, Haruka

301 7 p.
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97 Staphylococcus aureus as an emerging model to study bacterial cell division Ramos-León, Félix

301 7 p.
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98 Structural and functional insights into Listeria monocytogenes phage endolysin PlyP100: A promising food safety tool Bateman, Karson R.

301 7 p.
artikel
99 Structural basis for sirtuin 2 activity and modulation: Current state and opportunities Bernhard, Samuel P.

301 7 p.
artikel
100 Structural basis for the substrate specificity of Helix pomatia AMP deaminase and a chimeric ADGF adenosine deaminase Kaur, Gundeep

301 7 p.
artikel
101 Structural basis of cuproenzyme nitrite reduction at the level of a single hydrogen atom Fukuda, Yohta

301 7 p.
artikel
102 Structural insights and rational design of Pseudomonas putida KT2440 omega transaminases for enhanced biotransformation of (R)-PAC to (1R, 2S)-Norephedrine Das, Parijat

301 7 p.
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103 Structural insights into the catalytic cycle of G protein–coupled receptor kinase 5 and a possible regulatory site for potassium ion Chen, Yueyi

301 7 p.
artikel
104 Structure–function analysis defines the minimal functional C-terminal domain of the variant surface glycoprotein of Trypanosoma brucei Jones, Nicola G.

301 7 p.
artikel
105 SUMOylation targets O-GlcNAcase to chaperone-mediated autophagy Yan, Sheng

301 7 p.
artikel
106 Targeted incorporation of collagen IV to the basement membrane: A step forward for developing extracellular protein therapies Pokidysheva, Elena N.

301 7 p.
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107 Targeted removal of the 16S rRNA anti-Shine–Dalgarno sequence by a Mycobacterium tuberculosis MazF toxin Sherrier, Timothy W.

301 7 p.
artikel
108 The AhR regulates IFN-induced immune checkpoints in lung cancer cells through HNRNPH1, an RNA-binding protein, and INCR1, a novel long non-coding RNA Lara, Brian

301 7 p.
artikel
109 The binding sites of carbon dioxide, nitrous oxide, and xenon reveal a putative exhaust channel for bovine cytochrome c oxidase Muramoto, Kazumasa

301 7 p.
artikel
110 The common homocystinuria-associated P1173L variant of human methionine synthase impairs reductive methylation Guha, Arkajit

301 7 p.
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111 The common yet enigmatic activity of histone tail clipping Duncan, Elizabeth M.

301 7 p.
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112 The ER-associated degradation adaptor SEL1L is dispensable for ER homeostasis and the differentiation of spermatogenic cells Tushi, Nusrat Jahan

301 7 p.
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113 The gut microbiota mediates epoxy eicosanoid metabolism in the colon Jing, Nan

301 7 p.
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114 The hematin-dihydroartemisinin adduct mobilizes a potent mechanism to suppress β-hematin crystallization Azargoshasb, Hamidreza

301 7 p.
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115 The human autophagy-initiating complexes ULK1C and PI3KC3-C1 Chen, Minghao

301 7 p.
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116 The molecular basis of T cell receptor recognition of citrullinated tenascin-C presented by HLA-DR4 Dao, Hien Thy

301 7 p.
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117 The phosphatase activity of the PPP2R5D-PP2A holoenzyme modulates liprin-α1 liquid-liquid phase separation Mayer, Abigail

301 7 p.
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118 The Ser7 phosphorylation of RNA polymerase II-CTD is required for the recruitment of E3 ubiquitin ligase Asr1 and subtelomeric gene silencing Sudarshan, Nikita

301 7 p.
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119 The sphingosine-1-phosphate receptor 2 S1PR2 mediates chronic glucocorticoid exposure-induced hepatic steatosis and hypertriglyceridemia Chang, Maggie

301 7 p.
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120 The stage-specific roles of HIF-1α in regulating mESC pluripotency during oxygen transition Li, Meng

301 7 p.
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121 The transcription factor HOXA9 induces expression of the chromatin modifier SMYD3 to drive leukemogenesis Zhang, Liping

301 7 p.
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122 Topological isomers of a potent wound healing peptide: Structural insights and implications for bioactivity Raffaelli, Tiziano

301 7 p.
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123 Tripartite binding mode of cohesin-dockerin complexes from Ruminococcus flavefaciens involving naturally truncated dockerins Duarte, Marlene

301 7 p.
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124 Unifying perspectives on the activity and genotypic targeting of pharmacological chaperones Tedman, Austin

301 7 p.
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125 Unique structural features define the decarboxylation activity of a CYP152 fatty acid decarboxylase from Lacicoccus alkaliphilus Phaisan, Suppalak

301 7 p.
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126 USP10 inhibits the degradation of α-synuclein, a pathogenic factor associated with Parkinson's disease, by inhibiting chaperone-mediated autophagy Anisimov, Sergei

301 7 p.
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127 USP25 maintains KRAS expression and inhibiting the deubiquitinase suppresses KRAS signaling in human cancer Ma, Huailu

301 7 p.
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128 Written in chromatin: The enduring legacy of C. David Allis Strahl, Brian D.

301 7 p.
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129 WT EGFR and the oncogenic mutant EGFR (L858R) employ distinct mechanisms for export from the endoplasmic reticulum, a process critical for their activation Wang, Mo

301 7 p.
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130 YEATS2 O-GlcNAcylation promotes chromatin association of the ATAC complex and lung cancer tumorigenesis Zhao, Jianxin

301 7 p.
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                             130 gevonden resultaten
 
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