nr |
titel |
auteur |
tijdschrift |
jaar |
jaarg. |
afl. |
pagina('s) |
type |
1 |
A biosensor of protein foldedness identifies increased “holdase” activity of chaperones in the nucleus following increased cytosolic protein aggregation
|
Raeburn, Candice B. |
|
|
298 |
8 |
p. |
artikel |
2 |
Activity-based protein profiling reveals active serine proteases that drive malignancy of human ovarian clear cell carcinoma
|
Mehner, Christine |
|
|
298 |
8 |
p. |
artikel |
3 |
A human IgE bispecific antibody shows potent cytotoxic capacity mediated by monocytes
|
Vukovic, Natasa |
|
|
298 |
8 |
p. |
artikel |
4 |
Allosteric enhancement of the BCR-Abl1 kinase inhibition activity of nilotinib by cobinding of asciminib
|
Oruganti, Baswanth |
|
|
298 |
8 |
p. |
artikel |
5 |
An acyl-adenylate mimic reveals the structural basis for substrate recognition by the iterative siderophore synthetase DesD
|
Yang, Jinping |
|
|
298 |
8 |
p. |
artikel |
6 |
A natural fusion of flavodiiron, rubredoxin, and rubredoxin oxidoreductase domains is a self-sufficient water-forming oxidase of Trichomonas vaginalis
|
Abdulaziz, Evana N. |
|
|
298 |
8 |
p. |
artikel |
7 |
A naturally occurring membrane-anchored Gαs variant, XLαs, activates phospholipase Cβ4
|
Phan, Hoa T.N. |
|
|
298 |
8 |
p. |
artikel |
8 |
A new deep learning technique reveals the exclusive functional contributions of individual cancer mutations
|
Gupta, Prashant |
|
|
298 |
8 |
p. |
artikel |
9 |
A new paradigm for regulation of protein phosphatase 2A function via Src and Fyn kinase–mediated tyrosine phosphorylation
|
Sontag, Jean-Marie |
|
|
298 |
8 |
p. |
artikel |
10 |
Antibacterial peptide CyclomarinA creates toxicity by deregulating the Mycobacterium tuberculosis ClpC1–ClpP1P2 protease
|
Taylor, Gabrielle |
|
|
298 |
8 |
p. |
artikel |
11 |
A peptoid-based inhibitor of protein arginine methyltransferase 1 (PRMT1) induces apoptosis and autophagy in cancer cells
|
Brekker, Mollie A. |
|
|
298 |
8 |
p. |
artikel |
12 |
A purified energy-converting hydrogenase from Thermoanaerobacter kivui demonstrates coupled H+-translocation and reduction in vitro
|
Katsyv, Alexander |
|
|
298 |
8 |
p. |
artikel |
13 |
A quantitative high-throughput screen identifies compounds that lower expression of the SCA2-and ALS-associated gene ATXN2
|
Scoles, Daniel R. |
|
|
298 |
8 |
p. |
artikel |
14 |
A simple protocol for the production of highly deuterated proteins for biophysical studies
|
Li, Jess |
|
|
298 |
8 |
p. |
artikel |
15 |
A single amino acid residue tunes the stability of the fully reduced flavin cofactor and photorepair activity in photolyases
|
Wen, Bin |
|
|
298 |
8 |
p. |
artikel |
16 |
A small molecule toll-like receptor antagonist rescues α-synuclein fibril pathology
|
Chedid, Jessica |
|
|
298 |
8 |
p. |
artikel |
17 |
Astrocyte ethanol exposure reveals persistent and defined calcium response subtypes and associated gene signatures
|
Kim, Hyun-Bum |
|
|
298 |
8 |
p. |
artikel |
18 |
A transthyretin monomer intermediate undergoes local unfolding and transient interaction with oligomers in a kinetically concerted aggregation pathway
|
Sun, Xun |
|
|
298 |
8 |
p. |
artikel |
19 |
A UHM–ULM interface with unusual structural features contributes to U2AF2 and SF3B1 association for pre-mRNA splicing
|
Galardi, Justin W. |
|
|
298 |
8 |
p. |
artikel |
20 |
A WWP2–PTEN–KLF5 signaling axis regulates odontoblast differentiation and dentinogenesis in mice
|
Fu, Jing |
|
|
298 |
8 |
p. |
artikel |
21 |
Biochemical characterization of the first step in sulfonolipid biosynthesis in Alistipes finegoldii
|
Radka, Christopher D. |
|
|
298 |
8 |
p. |
artikel |
22 |
Bruton’s tyrosine kinase phosphorylates scaffolding and RNA-binding protein G3BP1 to induce stress granule aggregation during host sensing of foreign ribonucleic acids
|
Kim, Susana S-Y. |
|
|
298 |
8 |
p. |
artikel |
23 |
Calcium and the Ca-ATPase SPCA1 modulate plasma membrane abundance of ZIP8 and ZIP14 to regulate Mn(II) uptake in brain microvascular endothelial cells
|
Steimle, Brittany L. |
|
|
298 |
8 |
p. |
artikel |
24 |
Casein kinase 1δ/ε phosphorylates fused in sarcoma (FUS) and ameliorates FUS-mediated neurodegeneration
|
Kishino, Yuya |
|
|
298 |
8 |
p. |
artikel |
25 |
Cell-intrinsic Wnt4 ligand regulates mitochondrial oxidative phosphorylation in macrophages
|
Tlili, Mouna |
|
|
298 |
8 |
p. |
artikel |
26 |
β-Cells retain a pool of insulin-containing secretory vesicles regulated by adherens junctions and the cadherin-binding protein p120 catenin
|
Dissanayake, Waruni C. |
|
|
298 |
8 |
p. |
artikel |
27 |
Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in mice
|
Schumacher, Fabian |
|
|
298 |
8 |
p. |
artikel |
28 |
Characterizing unexpected interactions of a glutamine transporter inhibitor with members of the SLC1A transporter family
|
Freidman, Natasha J. |
|
|
298 |
8 |
p. |
artikel |
29 |
Clathrin adaptor AP-1–mediated Golgi export of amyloid precursor protein is crucial for the production of neurotoxic amyloid fragments
|
Januário, Yunan C. |
|
|
298 |
8 |
p. |
artikel |
30 |
Combined proteomic and biochemical analyses redefine the consensus sequence requirement for epidermal growth factor-like domain hydroxylation
|
Brewitz, Lennart |
|
|
298 |
8 |
p. |
artikel |
31 |
Coming full circle: On the origin and evolution of the looping model for enhancer–promoter communication
|
Popay, Tessa M. |
|
|
298 |
8 |
p. |
artikel |
32 |
Context-dependent pro- and anti-resection roles of ZKSCAN3 in the regulation of fork processing during replication stress
|
Yang, Zheng |
|
|
298 |
8 |
p. |
artikel |
33 |
Contribution of HIF-P4H isoenzyme inhibition to metabolism indicates major beneficial effects being conveyed by HIF-P4H-2 antagonism
|
Tapio, Joona |
|
|
298 |
8 |
p. |
artikel |
34 |
Copper inhibits protein maturation in the secretory pathway by targeting the Sec61 translocon in Saccharomyces cerevisiae
|
Saha, Nitu |
|
|
298 |
8 |
p. |
artikel |
35 |
Correction: A membrane ATPase without transporter activity: Guido Guidotti’s laboratory and the search for CD39
|
Oldach, Laurel |
|
|
298 |
8 |
p. |
artikel |
36 |
Correction: A novel NF-κB-inducing kinase-MAPK signaling pathway up-regulates NF-κB activity in melanoma cells
|
Dhawan, Punita |
|
|
298 |
8 |
p. |
artikel |
37 |
Correction: Antibody recognition of complement factor H reveals a flexible loop involved in atypical hemolytic uremic syndrome pathogenesis
|
Yokoo, Takanori |
|
|
298 |
8 |
p. |
artikel |
38 |
Correction: Schizosaccharomyces pombe Ppr10 and Mpa1 together mediate mitochondrial translational initiation
|
Luo, Ying |
|
|
298 |
8 |
p. |
artikel |
39 |
Cover
|
|
|
|
298 |
8 |
p. |
artikel |
40 |
Crystal structure of Grimontia hollisae collagenase provides insights into its novel substrate specificity toward collagen
|
Ikeuchi, Takeaki |
|
|
298 |
8 |
p. |
artikel |
41 |
Crystal structure of the Rubella virus protease reveals a unique papain-like protease fold
|
Cheong, Ezekiel Ze Ken |
|
|
298 |
8 |
p. |
artikel |
42 |
Crystal structure of Trypanosoma cruzi heme peroxidase and characterization of its substrate specificity and compound I intermediate
|
Freeman, Samuel L. |
|
|
298 |
8 |
p. |
artikel |
43 |
DEAD box 1 (DDX1) protein binds to and protects cytoplasmic stress response mRNAs in cells exposed to oxidative stress
|
Li, Lei |
|
|
298 |
8 |
p. |
artikel |
44 |
Disrupting the plastidic iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viability
|
Renaud, Eléa A. |
|
|
298 |
8 |
p. |
artikel |
45 |
Distinct basolateral amygdala excitatory inputs mediate the somatosensory and aversive-affective components of pain
|
Meng, Xiaojing |
|
|
298 |
8 |
p. |
artikel |
46 |
Elucidation of binding preferences of YEATS domains to site-specific acetylated nucleosome core particles
|
Kikuchi, Masaki |
|
|
298 |
8 |
p. |
artikel |
47 |
Energetic determinants of animal cell polarity regulator Par-3 interaction with the Par complex
|
Penkert, Rhiannon R. |
|
|
298 |
8 |
p. |
artikel |
48 |
Evolutionary origin and functional diversification of aminotransferases
|
Koper, Kaan |
|
|
298 |
8 |
p. |
artikel |
49 |
Exploring high-resolution chromatin interaction changes and functional enhancers of myogenic marker genes during myogenic differentiation
|
Long, Keren |
|
|
298 |
8 |
p. |
artikel |
50 |
Expression of a novel mycobacterial phosphodiesterase successfully lowers cAMP levels resulting in reduced tolerance to cell wall–targeting antimicrobials
|
Thomson, Michael |
|
|
298 |
8 |
p. |
artikel |
51 |
Extended DNA-binding interfaces beyond the canonical SAP domain contribute to the function of replication stress regulator SDE2 at DNA replication forks
|
Weinheimer, Alexandra S. |
|
|
298 |
8 |
p. |
artikel |
52 |
Genomic analysis of 1,25-dihydroxyvitamin D3 action in mouse intestine reveals compartment and segment-specific gene regulatory effects
|
Aita, Rohit |
|
|
298 |
8 |
p. |
artikel |
53 |
Glycogen synthase kinase homolog Rim11 regulates lipid synthesis through the phosphorylation of Pah1 phosphatidate phosphatase in yeast
|
Khondker, Shoily |
|
|
298 |
8 |
p. |
artikel |
54 |
GRASP55 regulates the unconventional secretion and aggregation of mutant huntingtin
|
Ahat, Erpan |
|
|
298 |
8 |
p. |
artikel |
55 |
Heterozygous p.Y955C mutation in DNA polymerase γ leads to alterations in bioenergetics, complex I subunit expression, and mtDNA replication
|
Rahman, Md. Mostafijur |
|
|
298 |
8 |
p. |
artikel |
56 |
Human testis–specific Y-encoded protein-like protein 5 is a histone H3/H4-specific chaperone that facilitates histone deposition in vitro
|
Dalui, Sambit |
|
|
298 |
8 |
p. |
artikel |
57 |
Identification and functional characterization of mRNAs that exhibit stop codon readthrough in Arabidopsis thaliana
|
Sahoo, Sarthak |
|
|
298 |
8 |
p. |
artikel |
58 |
Identification of a distal enhancer that determines the expression pattern of acute phase marker C-reactive protein
|
Wang, Ming-Yu |
|
|
298 |
8 |
p. |
artikel |
59 |
Identification of allosteric hotspots regulating the ribosomal RNA binding by antibiotic resistance-conferring Erm methyltransferases
|
Bhujbalrao, Ruchika |
|
|
298 |
8 |
p. |
artikel |
60 |
Identification of cell type–specific correlations between ERK activity and cell viability upon treatment with ERK1/2 inhibitors
|
Lebedev, Timofey D. |
|
|
298 |
8 |
p. |
artikel |
61 |
Identification of the amino acid residues involved in the species-dependent differences in the pyridoxine transport function of SLC19A3
|
Miyake, Kohei |
|
|
298 |
8 |
p. |
artikel |
62 |
Identification of the riboflavin cofactor-binding site in the Vibrio cholerae ion-pumping NQR complex: A novel structural motif in redox enzymes
|
Tuz, Karina |
|
|
298 |
8 |
p. |
artikel |
63 |
Impaired mitophagy in Sanfilippo a mice causes hypertriglyceridemia and brown adipose tissue activation
|
Tillo, Miguel |
|
|
298 |
8 |
p. |
artikel |
64 |
Incorporation of fucose into glycans independent of the GDP-fucose transporter SLC35C1 preferentially utilizes salvaged over de novo GDP-fucose
|
Skurska, Edyta |
|
|
298 |
8 |
p. |
artikel |
65 |
Inhibition of lipid kinase PIKfyve reveals a role for phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics through VPS34 activity
|
Saffi, Golam T. |
|
|
298 |
8 |
p. |
artikel |
66 |
Insights into the structural dynamics and helicase-catalyzed unfolding of plant RNA G-quadruplexes
|
Wang, Liu |
|
|
298 |
8 |
p. |
artikel |
67 |
Integrated regulation of PKA by fast and slow neurotransmission in the nucleus accumbens controls plasticity and stress responses
|
Thomas, Rachel |
|
|
298 |
8 |
p. |
artikel |
68 |
Intermolecular functional coupling between phosphoinositides and the potassium channel KcsA
|
Kiya, Takunari |
|
|
298 |
8 |
p. |
artikel |
69 |
In vitro single molecule and bulk phase studies reveal the AP-1 transcription factor cFos binds to DNA without its partner cJun
|
Leech, James T. |
|
|
298 |
8 |
p. |
artikel |
70 |
Lipoate protein ligase B primarily recognizes the C8-phosphopantetheine arm of its donor substrate and weakly binds the acyl carrier protein
|
Dhembla, Chetna |
|
|
298 |
8 |
p. |
artikel |
71 |
Mapping interactions between the CRAC activation domain and CC1 regulating the activity of the ER Ca2+ sensor STIM1
|
Shrestha, Nisha |
|
|
298 |
8 |
p. |
artikel |
72 |
Mechanisms orchestrating the enzymatic activity and cellular functions of deubiquitinases
|
Estavoyer, Benjamin |
|
|
298 |
8 |
p. |
artikel |
73 |
Metalloprotease ADAM9 cleaves ephrin-B ligands and differentially regulates Wnt and mTOR signaling downstream of Akt kinase in colorectal cancer cells
|
Chandrasekera, Pathirennehelage |
|
|
298 |
8 |
p. |
artikel |
74 |
Modularity of the hydrophobic core and evolution of functional diversity in fold A glycosyltransferases
|
Venkat, Aarya |
|
|
298 |
8 |
p. |
artikel |
75 |
Molecular basis for variations in the sensitivity of pathogenic rhodopsin variants to 9-cis-retinal
|
Roushar, Francis J. |
|
|
298 |
8 |
p. |
artikel |
76 |
Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox
|
Xie, Jing |
|
|
298 |
8 |
p. |
artikel |
77 |
Nuclear protein quality control in yeast: The latest INQuiries
|
Kumar, Arun |
|
|
298 |
8 |
p. |
artikel |
78 |
Nuclear ribonucleoprotein RALY targets virus nucleocapsid protein and induces autophagy to restrict porcine epidemic diarrhea virus replication
|
Qin, Wenzhen |
|
|
298 |
8 |
p. |
artikel |
79 |
Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir
|
Jemth, Ann-Sofie |
|
|
298 |
8 |
p. |
artikel |
80 |
Oncogenic KRAS G12C: Kinetic and redox characterization of covalent inhibition
|
Huynh, Minh V. |
|
|
298 |
8 |
p. |
artikel |
81 |
Overexpression of MRX9 impairs processing of RNAs encoding mitochondrial oxidative phosphorylation factors COB and COX1 in yeast
|
Chagas, Jhulia Almeida Clarck |
|
|
298 |
8 |
p. |
artikel |
82 |
Phosphate position is key in mediating transmembrane ion channel TMEM16A–phosphatidylinositol 4,5-bisphosphate interaction
|
Tembo, Maiwase |
|
|
298 |
8 |
p. |
artikel |
83 |
Phosphorylation of mixed lineage kinase MLK3 by cyclin-dependent kinases CDK1 and CDK2 controls ovarian cancer cell division
|
Cedeno-Rosario, Luis |
|
|
298 |
8 |
p. |
artikel |
84 |
Phosphorylation on Syk Y342 is important for both ITAM and hemITAM signaling in platelets
|
Kostyak, John C. |
|
|
298 |
8 |
p. |
artikel |
85 |
PKCα and PKCδ: Friends and Rivals
|
Black, Jennifer D. |
|
|
298 |
8 |
p. |
artikel |
86 |
PKGIα is activated by metal-dependent oxidation in vitro but not in intact cells
|
Aminzai, Sahar |
|
|
298 |
8 |
p. |
artikel |
87 |
Polyunsaturated fatty acids promote the rapid fusion of lipid droplets in Caenorhabditis elegans
|
Wang, Yanli |
|
|
298 |
8 |
p. |
artikel |
88 |
Profiling 26,000 Aplysia californica neurons by single cell mass spectrometry reveals neuronal populations with distinct neuropeptide profiles
|
Chan-Andersen, Peter C. |
|
|
298 |
8 |
p. |
artikel |
89 |
Proteasome activator 28γ (PA28γ) allosterically activates trypsin-like proteolysis by binding to the α-ring of the 20S proteasome
|
Thomas, Taylor A. |
|
|
298 |
8 |
p. |
artikel |
90 |
Proximity-based labeling reveals DNA damage–induced phosphorylation of fused in sarcoma (FUS) causes distinct changes in the FUS protein interactome
|
Johnson, Michelle A. |
|
|
298 |
8 |
p. |
artikel |
91 |
PvdM of fluorescent pseudomonads is required for the oxidation of ferribactin by PvdP in periplasmic pyoverdine maturation
|
Sugue, Michael-Frederick |
|
|
298 |
8 |
p. |
artikel |
92 |
Recent insights into noncanonical 5′ capping and decapping of RNA
|
Doamekpor, Selom K. |
|
|
298 |
8 |
p. |
artikel |
93 |
Reduction of protein disulfide isomerase results in open conformations and stimulates dynamic exchange between structural ensembles
|
Chinnaraj, Mathivanan |
|
|
298 |
8 |
p. |
artikel |
94 |
RNA editing enzyme ADAR1 controls miR-381-3p-mediated expression of multidrug resistance protein MRP4 via regulation of circRNA in human renal cells
|
Omata, Yuji |
|
|
298 |
8 |
p. |
artikel |
95 |
RNA induces unique tau strains and stabilizes Alzheimer’s disease seeds
|
Zwierzchowski-Zarate, Amy N. |
|
|
298 |
8 |
p. |
artikel |
96 |
Seed-competent tau monomer initiates pathology in a tauopathy mouse model
|
Mirbaha, Hilda |
|
|
298 |
8 |
p. |
artikel |
97 |
Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis
|
Dou, Qianhui |
|
|
298 |
8 |
p. |
artikel |
98 |
Self-activating G protein α subunits engage seven-transmembrane regulator of G protein signaling (RGS) proteins and a Rho guanine nucleotide exchange factor effector in the amoeba Naegleria fowleri
|
Bosch, Dustin E. |
|
|
298 |
8 |
p. |
artikel |
99 |
Structural biology of ex vivo mammalian prions
|
Artikis, Efrosini |
|
|
298 |
8 |
p. |
artikel |
100 |
Structural features of the protein kinase domain and targeted binding by small-molecule inhibitors
|
Arter, Chris |
|
|
298 |
8 |
p. |
artikel |
101 |
Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1
|
Bandekar, Sumit J. |
|
|
298 |
8 |
p. |
artikel |
102 |
Structural insights into the function-modulating effects of nanobody binding to the integrin receptor αMβ2
|
Jensen, Rasmus K. |
|
|
298 |
8 |
p. |
artikel |
103 |
Structural insights into the role of the WW2 domain on tandem WW–PPxY motif interactions of oxidoreductase WWOX
|
Rotem-Bamberger, Shahar |
|
|
298 |
8 |
p. |
artikel |
104 |
Subcellular dynamics and functional activity of the cleaved intracellular domain of the Na+ channel β1 subunit
|
Haworth, Alexander S. |
|
|
298 |
8 |
p. |
artikel |
105 |
Substoichiometric Hsp104 regulates the genesis and persistence of self-replicable amyloid seeds of Sup35 prion domain
|
Mahapatra, Sayanta |
|
|
298 |
8 |
p. |
artikel |
106 |
Sulfotyrosine residues: Interaction specificity determinants for extracellular protein–protein interactions
|
Stewart, Valley |
|
|
298 |
8 |
p. |
artikel |
107 |
The airway smooth muscle sodium/calcium exchanger NCLX is critical for airway remodeling and hyperresponsiveness in asthma
|
Johnson, Martin T. |
|
|
298 |
8 |
p. |
artikel |
108 |
The association of lipids with amyloid fibrils
|
Sanderson, John M. |
|
|
298 |
8 |
p. |
artikel |
109 |
The Casein kinase 1α agonist pyrvinium attenuates Wnt-mediated CK1α degradation via interaction with the E3 ubiquitin ligase component Cereblon
|
Shen, Chen |
|
|
298 |
8 |
p. |
artikel |
110 |
The conformational change of the protease inhibitor α2-macroglobulin is triggered by the retraction of the cleaved bait region from a central channel
|
Harwood, Seandean Lykke |
|
|
298 |
8 |
p. |
artikel |
111 |
The enzyme pseudooxynicotine amine oxidase from Pseudomonas putida S16 is not an oxidase, but a dehydrogenase
|
Choudhary, Vishakha |
|
|
298 |
8 |
p. |
artikel |
112 |
The PLEKHA7–PDZD11 complex regulates the localization of the calcium pump PMCA and calcium handling in cultured cells
|
Sluysmans, Sophie |
|
|
298 |
8 |
p. |
artikel |
113 |
The p97 segregase cofactor Ubxn7 facilitates replisome disassembly during S-phase
|
Tarcan, Zeynep |
|
|
298 |
8 |
p. |
artikel |
114 |
The sodium proton exchanger NHE9 regulates phagosome maturation and bactericidal activity in macrophages
|
Shamroukh, Habiba S. |
|
|
298 |
8 |
p. |
artikel |
115 |
The structural dynamics of full-length divisome transmembrane proteins FtsQ, FtsB, and FtsL in FtsQBL complex formation
|
Kong, Wai-Po |
|
|
298 |
8 |
p. |
artikel |
116 |
Tissue transglutaminase activates integrin-linked kinase and β-catenin in ovarian cancer
|
Condello, Salvatore |
|
|
298 |
8 |
p. |
artikel |
117 |
Transcriptional profiling reveals roles of intercellular Fgf9 signaling in astrocyte maturation and synaptic refinement during brainstem development
|
Brandebura, Ashley N. |
|
|
298 |
8 |
p. |
artikel |
118 |
Unraveling the toxic effects mediated by the neurodegenerative disease–associated S375G mutation of TDP-43 and its S375E phosphomimetic variant
|
Paron, Francesca |
|
|
298 |
8 |
p. |
artikel |
119 |
Whole-cell FRET monitoring of transcription factor activities enables functional annotation of signal transduction systems in living bacteria
|
Wang, Pengchao |
|
|
298 |
8 |
p. |
artikel |
120 |
Withdrawal: Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1
|
Cai, Jun |
|
|
298 |
8 |
p. |
artikel |