Digitale Bibliotheek
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                             120 gevonden resultaten
nr titel auteur tijdschrift jaar jaarg. afl. pagina('s) type
1 A biosensor of protein foldedness identifies increased “holdase” activity of chaperones in the nucleus following increased cytosolic protein aggregation Raeburn, Candice B.

298 8 p.
artikel
2 Activity-based protein profiling reveals active serine proteases that drive malignancy of human ovarian clear cell carcinoma Mehner, Christine

298 8 p.
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3 A human IgE bispecific antibody shows potent cytotoxic capacity mediated by monocytes Vukovic, Natasa

298 8 p.
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4 Allosteric enhancement of the BCR-Abl1 kinase inhibition activity of nilotinib by cobinding of asciminib Oruganti, Baswanth

298 8 p.
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5 An acyl-adenylate mimic reveals the structural basis for substrate recognition by the iterative siderophore synthetase DesD Yang, Jinping

298 8 p.
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6 A natural fusion of flavodiiron, rubredoxin, and rubredoxin oxidoreductase domains is a self-sufficient water-forming oxidase of Trichomonas vaginalis Abdulaziz, Evana N.

298 8 p.
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7 A naturally occurring membrane-anchored Gαs variant, XLαs, activates phospholipase Cβ4 Phan, Hoa T.N.

298 8 p.
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8 A new deep learning technique reveals the exclusive functional contributions of individual cancer mutations Gupta, Prashant

298 8 p.
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9 A new paradigm for regulation of protein phosphatase 2A function via Src and Fyn kinase–mediated tyrosine phosphorylation Sontag, Jean-Marie

298 8 p.
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10 Antibacterial peptide CyclomarinA creates toxicity by deregulating the Mycobacterium tuberculosis ClpC1–ClpP1P2 protease Taylor, Gabrielle

298 8 p.
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11 A peptoid-based inhibitor of protein arginine methyltransferase 1 (PRMT1) induces apoptosis and autophagy in cancer cells Brekker, Mollie A.

298 8 p.
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12 A purified energy-converting hydrogenase from Thermoanaerobacter kivui demonstrates coupled H+-translocation and reduction in vitro Katsyv, Alexander

298 8 p.
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13 A quantitative high-throughput screen identifies compounds that lower expression of the SCA2-and ALS-associated gene ATXN2 Scoles, Daniel R.

298 8 p.
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14 A simple protocol for the production of highly deuterated proteins for biophysical studies Li, Jess

298 8 p.
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15 A single amino acid residue tunes the stability of the fully reduced flavin cofactor and photorepair activity in photolyases Wen, Bin

298 8 p.
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16 A small molecule toll-like receptor antagonist rescues α-synuclein fibril pathology Chedid, Jessica

298 8 p.
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17 Astrocyte ethanol exposure reveals persistent and defined calcium response subtypes and associated gene signatures Kim, Hyun-Bum

298 8 p.
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18 A transthyretin monomer intermediate undergoes local unfolding and transient interaction with oligomers in a kinetically concerted aggregation pathway Sun, Xun

298 8 p.
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19 A UHM–ULM interface with unusual structural features contributes to U2AF2 and SF3B1 association for pre-mRNA splicing Galardi, Justin W.

298 8 p.
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20 A WWP2–PTEN–KLF5 signaling axis regulates odontoblast differentiation and dentinogenesis in mice Fu, Jing

298 8 p.
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21 Biochemical characterization of the first step in sulfonolipid biosynthesis in Alistipes finegoldii Radka, Christopher D.

298 8 p.
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22 Bruton’s tyrosine kinase phosphorylates scaffolding and RNA-binding protein G3BP1 to induce stress granule aggregation during host sensing of foreign ribonucleic acids Kim, Susana S-Y.

298 8 p.
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23 Calcium and the Ca-ATPase SPCA1 modulate plasma membrane abundance of ZIP8 and ZIP14 to regulate Mn(II) uptake in brain microvascular endothelial cells Steimle, Brittany L.

298 8 p.
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24 Casein kinase 1δ/ε phosphorylates fused in sarcoma (FUS) and ameliorates FUS-mediated neurodegeneration Kishino, Yuya

298 8 p.
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25 Cell-intrinsic Wnt4 ligand regulates mitochondrial oxidative phosphorylation in macrophages Tlili, Mouna

298 8 p.
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26 β-Cells retain a pool of insulin-containing secretory vesicles regulated by adherens junctions and the cadherin-binding protein p120 catenin Dissanayake, Waruni C.

298 8 p.
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27 Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in mice Schumacher, Fabian

298 8 p.
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28 Characterizing unexpected interactions of a glutamine transporter inhibitor with members of the SLC1A transporter family Freidman, Natasha J.

298 8 p.
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29 Clathrin adaptor AP-1–mediated Golgi export of amyloid precursor protein is crucial for the production of neurotoxic amyloid fragments Januário, Yunan C.

298 8 p.
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30 Combined proteomic and biochemical analyses redefine the consensus sequence requirement for epidermal growth factor-like domain hydroxylation Brewitz, Lennart

298 8 p.
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31 Coming full circle: On the origin and evolution of the looping model for enhancer–promoter communication Popay, Tessa M.

298 8 p.
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32 Context-dependent pro- and anti-resection roles of ZKSCAN3 in the regulation of fork processing during replication stress Yang, Zheng

298 8 p.
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33 Contribution of HIF-P4H isoenzyme inhibition to metabolism indicates major beneficial effects being conveyed by HIF-P4H-2 antagonism Tapio, Joona

298 8 p.
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34 Copper inhibits protein maturation in the secretory pathway by targeting the Sec61 translocon in Saccharomyces cerevisiae Saha, Nitu

298 8 p.
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35 Correction: A membrane ATPase without transporter activity: Guido Guidotti’s laboratory and the search for CD39 Oldach, Laurel

298 8 p.
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36 Correction: A novel NF-κB-inducing kinase-MAPK signaling pathway up-regulates NF-κB activity in melanoma cells Dhawan, Punita

298 8 p.
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37 Correction: Antibody recognition of complement factor H reveals a flexible loop involved in atypical hemolytic uremic syndrome pathogenesis Yokoo, Takanori

298 8 p.
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38 Correction: Schizosaccharomyces pombe Ppr10 and Mpa1 together mediate mitochondrial translational initiation Luo, Ying

298 8 p.
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39 Cover
298 8 p.
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40 Crystal structure of Grimontia hollisae collagenase provides insights into its novel substrate specificity toward collagen Ikeuchi, Takeaki

298 8 p.
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41 Crystal structure of the Rubella virus protease reveals a unique papain-like protease fold Cheong, Ezekiel Ze Ken

298 8 p.
artikel
42 Crystal structure of Trypanosoma cruzi heme peroxidase and characterization of its substrate specificity and compound I intermediate Freeman, Samuel L.

298 8 p.
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43 DEAD box 1 (DDX1) protein binds to and protects cytoplasmic stress response mRNAs in cells exposed to oxidative stress Li, Lei

298 8 p.
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44 Disrupting the plastidic iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viability Renaud, Eléa A.

298 8 p.
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45 Distinct basolateral amygdala excitatory inputs mediate the somatosensory and aversive-affective components of pain Meng, Xiaojing

298 8 p.
artikel
46 Elucidation of binding preferences of YEATS domains to site-specific acetylated nucleosome core particles Kikuchi, Masaki

298 8 p.
artikel
47 Energetic determinants of animal cell polarity regulator Par-3 interaction with the Par complex Penkert, Rhiannon R.

298 8 p.
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48 Evolutionary origin and functional diversification of aminotransferases Koper, Kaan

298 8 p.
artikel
49 Exploring high-resolution chromatin interaction changes and functional enhancers of myogenic marker genes during myogenic differentiation Long, Keren

298 8 p.
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50 Expression of a novel mycobacterial phosphodiesterase successfully lowers cAMP levels resulting in reduced tolerance to cell wall–targeting antimicrobials Thomson, Michael

298 8 p.
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51 Extended DNA-binding interfaces beyond the canonical SAP domain contribute to the function of replication stress regulator SDE2 at DNA replication forks Weinheimer, Alexandra S.

298 8 p.
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52 Genomic analysis of 1,25-dihydroxyvitamin D3 action in mouse intestine reveals compartment and segment-specific gene regulatory effects Aita, Rohit

298 8 p.
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53 Glycogen synthase kinase homolog Rim11 regulates lipid synthesis through the phosphorylation of Pah1 phosphatidate phosphatase in yeast Khondker, Shoily

298 8 p.
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54 GRASP55 regulates the unconventional secretion and aggregation of mutant huntingtin Ahat, Erpan

298 8 p.
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55 Heterozygous p.Y955C mutation in DNA polymerase γ leads to alterations in bioenergetics, complex I subunit expression, and mtDNA replication Rahman, Md. Mostafijur

298 8 p.
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56 Human testis–specific Y-encoded protein-like protein 5 is a histone H3/H4-specific chaperone that facilitates histone deposition in vitro Dalui, Sambit

298 8 p.
artikel
57 Identification and functional characterization of mRNAs that exhibit stop codon readthrough in Arabidopsis thaliana Sahoo, Sarthak

298 8 p.
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58 Identification of a distal enhancer that determines the expression pattern of acute phase marker C-reactive protein Wang, Ming-Yu

298 8 p.
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59 Identification of allosteric hotspots regulating the ribosomal RNA binding by antibiotic resistance-conferring Erm methyltransferases Bhujbalrao, Ruchika

298 8 p.
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60 Identification of cell type–specific correlations between ERK activity and cell viability upon treatment with ERK1/2 inhibitors Lebedev, Timofey D.

298 8 p.
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61 Identification of the amino acid residues involved in the species-dependent differences in the pyridoxine transport function of SLC19A3 Miyake, Kohei

298 8 p.
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62 Identification of the riboflavin cofactor-binding site in the Vibrio cholerae ion-pumping NQR complex: A novel structural motif in redox enzymes Tuz, Karina

298 8 p.
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63 Impaired mitophagy in Sanfilippo a mice causes hypertriglyceridemia and brown adipose tissue activation Tillo, Miguel

298 8 p.
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64 Incorporation of fucose into glycans independent of the GDP-fucose transporter SLC35C1 preferentially utilizes salvaged over de novo GDP-fucose Skurska, Edyta

298 8 p.
artikel
65 Inhibition of lipid kinase PIKfyve reveals a role for phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics through VPS34 activity Saffi, Golam T.

298 8 p.
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66 Insights into the structural dynamics and helicase-catalyzed unfolding of plant RNA G-quadruplexes Wang, Liu

298 8 p.
artikel
67 Integrated regulation of PKA by fast and slow neurotransmission in the nucleus accumbens controls plasticity and stress responses Thomas, Rachel

298 8 p.
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68 Intermolecular functional coupling between phosphoinositides and the potassium channel KcsA Kiya, Takunari

298 8 p.
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69 In vitro single molecule and bulk phase studies reveal the AP-1 transcription factor cFos binds to DNA without its partner cJun Leech, James T.

298 8 p.
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70 Lipoate protein ligase B primarily recognizes the C8-phosphopantetheine arm of its donor substrate and weakly binds the acyl carrier protein Dhembla, Chetna

298 8 p.
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71 Mapping interactions between the CRAC activation domain and CC1 regulating the activity of the ER Ca2+ sensor STIM1 Shrestha, Nisha

298 8 p.
artikel
72 Mechanisms orchestrating the enzymatic activity and cellular functions of deubiquitinases Estavoyer, Benjamin

298 8 p.
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73 Metalloprotease ADAM9 cleaves ephrin-B ligands and differentially regulates Wnt and mTOR signaling downstream of Akt kinase in colorectal cancer cells Chandrasekera, Pathirennehelage

298 8 p.
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74 Modularity of the hydrophobic core and evolution of functional diversity in fold A glycosyltransferases Venkat, Aarya

298 8 p.
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75 Molecular basis for variations in the sensitivity of pathogenic rhodopsin variants to 9-cis-retinal Roushar, Francis J.

298 8 p.
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76 Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox Xie, Jing

298 8 p.
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77 Nuclear protein quality control in yeast: The latest INQuiries Kumar, Arun

298 8 p.
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78 Nuclear ribonucleoprotein RALY targets virus nucleocapsid protein and induces autophagy to restrict porcine epidemic diarrhea virus replication Qin, Wenzhen

298 8 p.
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79 Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir Jemth, Ann-Sofie

298 8 p.
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80 Oncogenic KRAS G12C: Kinetic and redox characterization of covalent inhibition Huynh, Minh V.

298 8 p.
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81 Overexpression of MRX9 impairs processing of RNAs encoding mitochondrial oxidative phosphorylation factors COB and COX1 in yeast Chagas, Jhulia Almeida Clarck

298 8 p.
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82 Phosphate position is key in mediating transmembrane ion channel TMEM16A–phosphatidylinositol 4,5-bisphosphate interaction Tembo, Maiwase

298 8 p.
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83 Phosphorylation of mixed lineage kinase MLK3 by cyclin-dependent kinases CDK1 and CDK2 controls ovarian cancer cell division Cedeno-Rosario, Luis

298 8 p.
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84 Phosphorylation on Syk Y342 is important for both ITAM and hemITAM signaling in platelets Kostyak, John C.

298 8 p.
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85 PKCα and PKCδ: Friends and Rivals Black, Jennifer D.

298 8 p.
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86 PKGIα is activated by metal-dependent oxidation in vitro but not in intact cells Aminzai, Sahar

298 8 p.
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87 Polyunsaturated fatty acids promote the rapid fusion of lipid droplets in Caenorhabditis elegans Wang, Yanli

298 8 p.
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88 Profiling 26,000 Aplysia californica neurons by single cell mass spectrometry reveals neuronal populations with distinct neuropeptide profiles Chan-Andersen, Peter C.

298 8 p.
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89 Proteasome activator 28γ (PA28γ) allosterically activates trypsin-like proteolysis by binding to the α-ring of the 20S proteasome Thomas, Taylor A.

298 8 p.
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90 Proximity-based labeling reveals DNA damage–induced phosphorylation of fused in sarcoma (FUS) causes distinct changes in the FUS protein interactome Johnson, Michelle A.

298 8 p.
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91 PvdM of fluorescent pseudomonads is required for the oxidation of ferribactin by PvdP in periplasmic pyoverdine maturation Sugue, Michael-Frederick

298 8 p.
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92 Recent insights into noncanonical 5′ capping and decapping of RNA Doamekpor, Selom K.

298 8 p.
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93 Reduction of protein disulfide isomerase results in open conformations and stimulates dynamic exchange between structural ensembles Chinnaraj, Mathivanan

298 8 p.
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94 RNA editing enzyme ADAR1 controls miR-381-3p-mediated expression of multidrug resistance protein MRP4 via regulation of circRNA in human renal cells Omata, Yuji

298 8 p.
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95 RNA induces unique tau strains and stabilizes Alzheimer’s disease seeds Zwierzchowski-Zarate, Amy N.

298 8 p.
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96 Seed-competent tau monomer initiates pathology in a tauopathy mouse model Mirbaha, Hilda

298 8 p.
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97 Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis Dou, Qianhui

298 8 p.
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98 Self-activating G protein α subunits engage seven-transmembrane regulator of G protein signaling (RGS) proteins and a Rho guanine nucleotide exchange factor effector in the amoeba Naegleria fowleri Bosch, Dustin E.

298 8 p.
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99 Structural biology of ex vivo mammalian prions Artikis, Efrosini

298 8 p.
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100 Structural features of the protein kinase domain and targeted binding by small-molecule inhibitors Arter, Chris

298 8 p.
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101 Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1 Bandekar, Sumit J.

298 8 p.
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102 Structural insights into the function-modulating effects of nanobody binding to the integrin receptor αMβ2 Jensen, Rasmus K.

298 8 p.
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103 Structural insights into the role of the WW2 domain on tandem WW–PPxY motif interactions of oxidoreductase WWOX Rotem-Bamberger, Shahar

298 8 p.
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104 Subcellular dynamics and functional activity of the cleaved intracellular domain of the Na+ channel β1 subunit Haworth, Alexander S.

298 8 p.
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105 Substoichiometric Hsp104 regulates the genesis and persistence of self-replicable amyloid seeds of Sup35 prion domain Mahapatra, Sayanta

298 8 p.
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106 Sulfotyrosine residues: Interaction specificity determinants for extracellular protein–protein interactions Stewart, Valley

298 8 p.
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107 The airway smooth muscle sodium/calcium exchanger NCLX is critical for airway remodeling and hyperresponsiveness in asthma Johnson, Martin T.

298 8 p.
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108 The association of lipids with amyloid fibrils Sanderson, John M.

298 8 p.
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109 The Casein kinase 1α agonist pyrvinium attenuates Wnt-mediated CK1α degradation via interaction with the E3 ubiquitin ligase component Cereblon Shen, Chen

298 8 p.
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110 The conformational change of the protease inhibitor α2-macroglobulin is triggered by the retraction of the cleaved bait region from a central channel Harwood, Seandean Lykke

298 8 p.
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111 The enzyme pseudooxynicotine amine oxidase from Pseudomonas putida S16 is not an oxidase, but a dehydrogenase Choudhary, Vishakha

298 8 p.
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112 The PLEKHA7–PDZD11 complex regulates the localization of the calcium pump PMCA and calcium handling in cultured cells Sluysmans, Sophie

298 8 p.
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113 The p97 segregase cofactor Ubxn7 facilitates replisome disassembly during S-phase Tarcan, Zeynep

298 8 p.
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114 The sodium proton exchanger NHE9 regulates phagosome maturation and bactericidal activity in macrophages Shamroukh, Habiba S.

298 8 p.
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115 The structural dynamics of full-length divisome transmembrane proteins FtsQ, FtsB, and FtsL in FtsQBL complex formation Kong, Wai-Po

298 8 p.
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116 Tissue transglutaminase activates integrin-linked kinase and β-catenin in ovarian cancer Condello, Salvatore

298 8 p.
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117 Transcriptional profiling reveals roles of intercellular Fgf9 signaling in astrocyte maturation and synaptic refinement during brainstem development Brandebura, Ashley N.

298 8 p.
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118 Unraveling the toxic effects mediated by the neurodegenerative disease–associated S375G mutation of TDP-43 and its S375E phosphomimetic variant Paron, Francesca

298 8 p.
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119 Whole-cell FRET monitoring of transcription factor activities enables functional annotation of signal transduction systems in living bacteria Wang, Pengchao

298 8 p.
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120 Withdrawal: Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1 Cai, Jun

298 8 p.
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                             120 gevonden resultaten
 
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