| nr |
titel |
auteur |
tijdschrift |
jaar |
jaarg. |
afl. |
pagina('s) |
type |
| 1 |
A bispecific antibody targeting HER2 and PD-L1 inhibits tumor growth with superior efficacy
|
Chen, Yi-Li
|
|
|
297 |
6 |
p.
|
artikel
|
| 2 |
A GX2GX3G motif facilitates acyl chain sequestration by Saccharomyces cerevisiae acyl carrier protein
|
Garima,
|
|
|
297 |
6 |
p.
|
artikel
|
| 3 |
ALG-2 and peflin regulate COPII targeting and secretion in response to calcium signaling
|
Sargeant, John
|
|
|
297 |
6 |
p.
|
artikel
|
| 4 |
A missense mutation converts the Na+,K+-ATPase into an ion channel and causes therapy-resistant epilepsy
|
Ygberg, Sofia
|
|
|
297 |
6 |
p.
|
artikel
|
| 5 |
An acetylation-enhanced interaction between transcription factor Sox2 and the steroid receptor coactivators facilitates Sox2 transcriptional activity and function
|
Huang, Yuanyong
|
|
|
297 |
6 |
p.
|
artikel
|
| 6 |
A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein
|
Littler, Dene R.
|
|
|
297 |
6 |
p.
|
artikel
|
| 7 |
A novel C-type lectin activates the complement cascade in the primitive oyster Crassostrea gigas
|
Sun, Jiejie
|
|
|
297 |
6 |
p.
|
artikel
|
| 8 |
A retinoic acid receptor β2 agonist attenuates transcriptome and metabolome changes underlying nonalcohol-associated fatty liver disease
|
Tang, Xiao-Han
|
|
|
297 |
6 |
p.
|
artikel
|
| 9 |
Astrocytic transcription factor REST upregulates glutamate transporter EAAT2, protecting dopaminergic neurons from manganese-induced excitotoxicity
|
Pajarillo, Edward
|
|
|
297 |
6 |
p.
|
artikel
|
| 10 |
BAd-CRISPR: Inducible gene knockout in interscapular brown adipose tissue of adult mice
|
Romanelli, Steven M.
|
|
|
297 |
6 |
p.
|
artikel
|
| 11 |
Binding with heat shock cognate protein HSC70 fine-tunes the Golgi association of the small GTPase ARL5B
|
Jaimon, Ebsy
|
|
|
297 |
6 |
p.
|
artikel
|
| 12 |
Bone morphogenetic protein 6–mediated crosstalk between endothelial cells and hepatocytes recapitulates the iron-sensing pathway in vitro
|
Wang, Shijin
|
|
|
297 |
6 |
p.
|
artikel
|
| 13 |
Caspase-6 promotes activation of the caspase-11-NLRP3 inflammasome during gram-negative bacterial infections
|
Zheng, Min
|
|
|
297 |
6 |
p.
|
artikel
|
| 14 |
Characterization of a lytic polysaccharide monooxygenase from Aspergillus fumigatus shows functional variation among family AA11 fungal LPMOs
|
Støpamo, Fredrik Gjerstad
|
|
|
297 |
6 |
p.
|
artikel
|
| 15 |
Cholesterol and sphingomyelin are critical for Fcγ receptor–mediated phagocytosis of Cryptococcus neoformans by macrophages
|
Bryan, Arielle M.
|
|
|
297 |
6 |
p.
|
artikel
|
| 16 |
Coevolution of the bacterial pheromone ComS and sensor ComR fine-tunes natural transformation in streptococci
|
Ledesma-García, Laura
|
|
|
297 |
6 |
p.
|
artikel
|
| 17 |
Collagen’s primary structure determines collagen:HSP47 complex stoichiometry
|
Abraham, Elena T.
|
|
|
297 |
6 |
p.
|
artikel
|
| 18 |
Correction: Enzymology and significance of protein histidine methylation
|
Jakobsson, Magnus E.
|
|
|
297 |
6 |
p.
|
artikel
|
| 19 |
Correction: PCBP1 and PCBP2 both bind heavily oxidized RNA but cause opposing outcomes, suppressing or increasing apoptosis under oxidative conditions
|
Ishii, Takashi
|
|
|
297 |
6 |
p.
|
artikel
|
| 20 |
Cover
|
|
|
|
297 |
6 |
p.
|
artikel
|
| 21 |
CRISPR/Cas9-mediated SARM1 knockout and epitope-tagged mice reveal that SARM1 does not regulate nuclear transcription, but is expressed in macrophages
|
Doran, Ciara G.
|
|
|
297 |
6 |
p.
|
artikel
|
| 22 |
Cyclic peptides with a distinct arginine-fork motif recognize the HIV trans-activation response RNA in vitro and in cells
|
Chavali, Sai Shashank
|
|
|
297 |
6 |
p.
|
artikel
|
| 23 |
Decoding the impact of disease-causing mutations in an essential aminoacyl-tRNA synthetase
|
Sissler, Marie
|
|
|
297 |
6 |
p.
|
artikel
|
| 24 |
Designer proteins that competitively inhibit Gαq by targeting its effector site
|
Hussain, Mahmud
|
|
|
297 |
6 |
p.
|
artikel
|
| 25 |
Development of a versatile HPLC-based method to evaluate the activation status of small GTPases
|
Araki, Makoto
|
|
|
297 |
6 |
p.
|
artikel
|
| 26 |
Disruption of the PDZ domain–binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis, and reward motivation
|
Sørensen, Gunnar
|
|
|
297 |
6 |
p.
|
artikel
|
| 27 |
Division of labor between the pore-1 loops of the D1 and D2 AAA+ rings coordinates substrate selectivity of the ClpAP protease
|
Zuromski, Kristin L.
|
|
|
297 |
6 |
p.
|
artikel
|
| 28 |
Engineered variants of the Ras effector protein RASSF5 (NORE1A) promote anticancer activities in lung adenocarcinoma
|
Singh, Anamika
|
|
|
297 |
6 |
p.
|
artikel
|
| 29 |
FBXO7 triggers caspase 8-mediated proteolysis of the transcription factor FOXO4 and exacerbates neuronal cytotoxicity
|
Lee, Su Hyoun
|
|
|
297 |
6 |
p.
|
artikel
|
| 30 |
Fine-tuning spermidine binding modes in the putrescine binding protein PotF
|
Kröger, Pascal
|
|
|
297 |
6 |
p.
|
artikel
|
| 31 |
Functional consequences of TCF4 missense substitutions associated with Pitt-Hopkins syndrome, mild intellectual disability, and schizophrenia
|
Sirp, Alex
|
|
|
297 |
6 |
p.
|
artikel
|
| 32 |
Fungal effector SIB1 of Colletotrichum orbiculare has unique structural features and can suppress plant immunity in Nicotiana benthamiana
|
Zhang, Ru
|
|
|
297 |
6 |
p.
|
artikel
|
| 33 |
GRP75 mediates endoplasmic reticulum–mitochondria coupling during palmitate-induced pancreatic β-cell apoptosis
|
Tiwary, Shweta
|
|
|
297 |
6 |
p.
|
artikel
|
| 34 |
Hairy and enhancer of split 1 is a primary effector of NOTCH2 signaling and induces osteoclast differentiation and function
|
Yu, Jungeun
|
|
|
297 |
6 |
p.
|
artikel
|
| 35 |
Hepatocyte polarity establishment and apical lumen formation are organized by Par3, Cdc42, and aPKC in conjunction with Lgl
|
Tocan, Vlad
|
|
|
297 |
6 |
p.
|
artikel
|
| 36 |
Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis–like phenotypes
|
Dall, Morten
|
|
|
297 |
6 |
p.
|
artikel
|
| 37 |
Histone deacetylase 5 deacetylates the phosphatase PP2A for positively regulating NF-κB signaling
|
Xu, Chonghui
|
|
|
297 |
6 |
p.
|
artikel
|
| 38 |
Hydrophobicity-tuned anion responsiveness underlies endosomolytic cargo delivery mediated by amphipathic vehicle peptides
|
Chen, Xiaolong
|
|
|
297 |
6 |
p.
|
artikel
|
| 39 |
Identification of small-molecule allosteric modulators that act as enhancers/disrupters of rhodopsin oligomerization
|
Getter, Tamar
|
|
|
297 |
6 |
p.
|
artikel
|
| 40 |
Identification of TRAMs as sphingolipid-binding proteins using a photoactivatable and clickable short-chain ceramide analog
|
Deng, Yaqin
|
|
|
297 |
6 |
p.
|
artikel
|
| 41 |
Interchangeable utilization of metals: New perspectives on the impacts of metal ions employed in ancient and extant biomolecules
|
Smethurst, Daniel G.J.
|
|
|
297 |
6 |
p.
|
artikel
|
| 42 |
Loss of full-length DNA replication regulator Rif1 in two-cell embryos is associated with zygotic transcriptional activation
|
Yoshizawa-Sugata, Naoko
|
|
|
297 |
6 |
p.
|
artikel
|
| 43 |
Macrophage polarization state affects lipid composition and the channeling of exogenous fatty acids into endogenous lipid pools
|
Morgan, Pooranee K.
|
|
|
297 |
6 |
p.
|
artikel
|
| 44 |
Malonyl-acyl carrier protein decarboxylase activity promotes fatty acid and cell envelope biosynthesis in Proteobacteria
|
Whaley, Sarah G.
|
|
|
297 |
6 |
p.
|
artikel
|
| 45 |
miR-199a-5p inhibits the expression of ABCB11 in obstructive cholestasis
|
Balasubramaniyan, Natarajan
|
|
|
297 |
6 |
p.
|
artikel
|
| 46 |
Mitophagy mediates metabolic reprogramming of induced pluripotent stem cells undergoing endothelial differentiation
|
Krantz, Sarah
|
|
|
297 |
6 |
p.
|
artikel
|
| 47 |
Molecular insights into substrate recognition and catalysis by phthalate dioxygenase from Comamonas testosteroni
|
Mahto, Jai Krishna
|
|
|
297 |
6 |
p.
|
artikel
|
| 48 |
Multiple variants of the human presequence translocase motor subunit Magmas govern the mitochondrial import
|
Waingankar, Tejashree Pradip
|
|
|
297 |
6 |
p.
|
artikel
|
| 49 |
N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate
|
Gottlieb, Leah
|
|
|
297 |
6 |
p.
|
artikel
|
| 50 |
Patient mutations in human ATP:cob(I)alamin adenosyltransferase differentially affect its catalytic versus chaperone functions
|
Gouda, Harsha
|
|
|
297 |
6 |
p.
|
artikel
|
| 51 |
Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity
|
Faruk, Mohammad Omar
|
|
|
297 |
6 |
p.
|
artikel
|
| 52 |
Phosphoinositide regulates dynamic movement of the S4 voltage sensor in the second repeat in two-pore channel 3
|
Hirazawa, Kiichi
|
|
|
297 |
6 |
p.
|
artikel
|
| 53 |
Proximity-dependent biotinylation detects associations between SARS coronavirus nonstructural protein 1 and stress granule–associated proteins
|
Gerassimovich, Yevgeniy A.
|
|
|
297 |
6 |
p.
|
artikel
|
| 54 |
Purification of an insect juvenile hormone receptor complex enables insights into its post-translational phosphorylation
|
Jindra, Marek
|
|
|
297 |
6 |
p.
|
artikel
|
| 55 |
Rescuing activity of oxygen-damaged pyruvate formate-lyase by a spare part protein
|
Andorfer, Mary C.
|
|
|
297 |
6 |
p.
|
artikel
|
| 56 |
Resistance of Acta2 R149C/+ mice to aortic disease is associated with defective release of mutant smooth muscle α-actin from the chaperonin-containing TCP1 folding complex
|
Chen, Jiyuan
|
|
|
297 |
6 |
p.
|
artikel
|
| 57 |
SARS-CoV-2 beta variant substitutions alter spike glycoprotein receptor binding domain structure and stability
|
Moss, Daniel L.
|
|
|
297 |
6 |
p.
|
artikel
|
| 58 |
Sphingomyelin synthases 1 and 2 exhibit phosphatidylcholine phospholipase C activity
|
Chiang, Yeun-po
|
|
|
297 |
6 |
p.
|
artikel
|
| 59 |
Structural basis for anti-CRISPR repression mediated by bacterial operon proteins Aca1 and Aca2
|
Liu, Yanhong
|
|
|
297 |
6 |
p.
|
artikel
|
| 60 |
Structural basis of RNA polymerase recycling by the Swi2/Snf2 family of ATPase RapA in Escherichia coli
|
Qayyum, M. Zuhaib
|
|
|
297 |
6 |
p.
|
artikel
|
| 61 |
Structural basis of the TAM domain of BAZ2A in binding to DNA or RNA independent of methylation status
|
Chen, Sizhuo
|
|
|
297 |
6 |
p.
|
artikel
|
| 62 |
Structural insights into multifunctionality of human FACT complex subunit hSSRP1
|
Li, Xuehui
|
|
|
297 |
6 |
p.
|
artikel
|
| 63 |
Structure of a bacterial α-1,2-glucosidase defines mechanisms of hydrolysis and substrate specificity in GH65 family hydrolases
|
Nakamura, Shuntaro
|
|
|
297 |
6 |
p.
|
artikel
|
| 64 |
Synergistic and additive interactions between receptor signaling networks drive the regulatory T cell versus T helper 17 cell fate choice
|
Prado, Douglas S.
|
|
|
297 |
6 |
p.
|
artikel
|
| 65 |
β-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins
|
Ninkina, Natalia
|
|
|
297 |
6 |
p.
|
artikel
|
| 66 |
Systematic profiling of temperature- and retinal-sensitive rhodopsin variants by deep mutational scanning
|
McKee, Andrew G.
|
|
|
297 |
6 |
p.
|
artikel
|
| 67 |
Termination of DNA replication at Tus-ter barriers results in under-replication of template DNA
|
Jameson, Katie H.
|
|
|
297 |
6 |
p.
|
artikel
|
| 68 |
The C2 entity of chitosugars is crucial in molecular selectivity of the Vibrio campbellii chitoporin
|
Suginta, Wipa
|
|
|
297 |
6 |
p.
|
artikel
|
| 69 |
The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation
|
Grasso, Michael
|
|
|
297 |
6 |
p.
|
artikel
|
| 70 |
The Escherichia coli two-component signal sensor BarA binds protonated acetate via a conserved hydrophobic-binding pocket
|
Alvarez, Adrián F.
|
|
|
297 |
6 |
p.
|
artikel
|
| 71 |
The GPCR–β-arrestin complex allosterically activates C-Raf by binding its amino terminus
|
Zang, Yunxiang
|
|
|
297 |
6 |
p.
|
artikel
|
| 72 |
The legumain McPAL1 from Momordica cochinchinensis is a highly stable Asx-specific splicing enzyme
|
Liew, Heng Tai
|
|
|
297 |
6 |
p.
|
artikel
|
| 73 |
The lipopolysaccharide-transporter complex LptB2FG also displays adenylate kinase activity in vitro dependent on the binding partners LptC/LptA
|
Baeta, Tiago
|
|
|
297 |
6 |
p.
|
artikel
|
| 74 |
The metastasis suppressor NDRG1 directly regulates androgen receptor signaling in prostate cancer
|
Lim, Syer C.
|
|
|
297 |
6 |
p.
|
artikel
|
| 75 |
The mGluR6 ligand-binding domain, but not the C-terminal domain, is required for synaptic localization in retinal ON-bipolar cells
|
Agosto, Melina A.
|
|
|
297 |
6 |
p.
|
artikel
|
| 76 |
The minimal structure for iodotyrosine deiodinase function is defined by an outlier protein from the thermophilic bacterium Thermotoga neapolitana
|
Sun, Zuodong
|
|
|
297 |
6 |
p.
|
artikel
|
| 77 |
The nuclear receptor RORα preserves cardiomyocyte mitochondrial function by regulating caveolin-3-mediated mitophagy
|
Beak, Ju Youn
|
|
|
297 |
6 |
p.
|
artikel
|
| 78 |
The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility
|
Spliid, Charlotte B.
|
|
|
297 |
6 |
p.
|
artikel
|
| 79 |
The steroidal lactone withaferin A impedes T-cell motility by inhibiting the kinase ZAP70 and subsequent kinome signaling
|
Fazil, Mobashar Hussain Urf Turabe
|
|
|
297 |
6 |
p.
|
artikel
|
| 80 |
The structural basis for high affinity binding of α1-acid glycoprotein to the potent antitumor compound UCN-01
|
Landin, Erik J.B.
|
|
|
297 |
6 |
p.
|
artikel
|
| 81 |
The synaptic scaffolding protein CNKSR2 interacts with CYTH2 to mediate hippocampal granule cell development
|
Ito, Hidenori
|
|
|
297 |
6 |
p.
|
artikel
|
| 82 |
The unity of opposites: Strategic interplay between bacterial effectors to regulate cellular homeostasis
|
Iyer, Shalini
|
|
|
297 |
6 |
p.
|
artikel
|
| 83 |
Transduction of modified factor VIII gene improves lentiviral gene therapy efficacy for hemophilia A
|
Gong, Jie
|
|
|
297 |
6 |
p.
|
artikel
|
| 84 |
Tumor suppressor p53 promotes ferroptosis in oxidative stress conditions independent of modulation of ferroptosis by p21, CDKs, RB, and E2F
|
Kuganesan, Nishanth
|
|
|
297 |
6 |
p.
|
artikel
|
| 85 |
Universal and strain specific structure features of segment 8 genomic RNA of influenza A virus—application of 4-thiouridine photocrosslinking
|
Soszynska-Jozwiak, Marta
|
|
|
297 |
6 |
p.
|
artikel
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