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                             47 results found
no title author magazine year volume issue page(s) type
1 Allosteric Regulation of Mammalian Pantothenate Kinase* * This work was supported in whole or in part by National Institutes of Health Grants GM034496 (to C. O. R.), GM062896 (to S. J.), and Cancer Center Support Grant CA21765 and the American Lebanese Syrian Associated Charities. The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Subramanian, Chitra
291 42 p. 22302-22314
 article
2 Alternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4* * This work was supported by Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant RGPIN-2015-04645, the Canada Foundation of Innovation Leaders Opportunity Fund Grant 32565, Alzheimer Society of Canada Young Investigator Award PT-58872, Fonds d'innovation Pfizer-Fonds de recherche Santé Québec (FRQS) sur la maladie d'Alzheimer et les maladies apparentées 31288, McGill University Startup funding, and McGill Faculty of Medicine Incentive funding. The authors declare that they have no conflicts of interest with the contents of this article. Paschkowsky, Sandra
291 42 p. 21903-21912
 article
3 A Novel Developmental Role for Dopaminergic SigNAling to Specify Hypothalamic Neurotransmitter Identity* * This work was supported by The Academy of Finland and Sigrid Juselius Foundation (to P. P.) and DP2 MH100008 (to J. L. B.). The authors declare that they have no conflicts of interest with the contents of this article. This article contains supplemental Figure S1. Chen, Yu-Chia
291 42 p. 21880-21892
 article
4 Anthrax Toxin Protective Antigen Variants That Selectively Utilize either the CMG2 or TEM8 Receptors for Cellular Uptake and Tumor Targeting* * This work was supported by the intramural research programs of the NIAID and the NIDCR, National Institutes of Health. K. H. C., S. L., C. E. L., T. H. B., and S. H. L. are inventors on patents of targeted toxins that have all been assigned to the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This article contains supplemental Files 1 and 2. Chen, Kuang-Hua
291 42 p. 22021-22029
 article
5 ATP hydrolysis Promotes Duplex DNA Release by the RecA Presynaptic Complex* * This work was supported by National Institutes of Health Grant R356M118026 (to E. C. G.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Lee, Ja Yil
291 42 p. 22218-22230
 article
6 Author Index
291 42 p. vii-viii
 article
7 Bacterial N-Glycosylation Efficiency Is Dependent on the Structural Context of Target Sequons* * This work was supported by National Institutes of Health Grants GM-039334 (to B. I.) and AI109857 (to J. M. S.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This article contains supplemental Tables S1 and S2 and Figs. S1 and S2. Silverman, Julie Michelle
291 42 p. 22001-22010
 article
8 Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses* * This work was supported by NIDDK, National Institutes of Health Grants RO1 DK043051 and P30DK57521 (to B. B. K.) and RO1 DK106210 (to B. B. K. and A. S.), a grant from the JPB Foundation (to B. B. K.), Leona M. and Harry B. Helmsley Charitable Trust Grant 2012-PG-MED002 (to A. S.), Fundação de Amparo a Pesquisa do Estado de São Paulo 2014/02218-6 and 2011/15682-4 (to A. C.), and 5T32DK007516-31 (to B. B. K. and J. L.). B. B. K., A. S., and P. V. are inventors on a patent and patent applications related to the fatty acid hydroxy fatty acids. J. L. is an inventor on a patent application related to the lipids. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Lee, Jennifer
291 42 p. 22207-22217
 article
9 Death-associated Protein Kinase-1 Expression and Autophagy in Chronic Lymphocytic Leukemia Are Dependent on Activating Transcription Factor-6 and CCAAT/Enhancer-binding Protein-β* * This work was supported by National Institutes of Health Grant CA78282 (to D. V. K.), and Cigarette Restitution funds from the University of Maryland Greenebaum Cancer Center. The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Gade, Padmaja
291 42 p. 22030-22042
 article
10 Differential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF-I. Entingh-Pearsall, Amelia
291 42 p. 22339-22340
 article
11 Dual sites of protein initiation control the localization and myristoylation of methionine sulfoxide reductase A. Kim, Geumsoo
291 42 p. 22338
 article
12 Early Growth Response 1 (Egr-1) Is a Transcriptional Activator of β-Secretase 1 (BACE-1) in the Brain* * This work was supported by grants from Canadian Institute for Health Research and Alzheimer's Society of Canada. The authors declare that they have no conflicts of interest with the contents of this article. Qin, Xike
291 42 p. 22276-22287
 article
13 Editorial Board
291 42 p. 1-3
 article
14 Effects of the Nrf2 Protein Modulator Salvianolic Acid A Alone or Combined with Metformin on Diabetes-associated Macrovascular and Renal Injury* * This work was supported by National Science and Technology Major Projects for “Major New Drugs Innovation and Development” Grants 2013ZX09508104 and 2013ZX09402203 (to G. D.), Doctoral Innovation Fund of Peking Union Medical College Grant 10023-1007-1020 (to P. W.), and National Natural Science Foundation of China Grant 81470159 (to X. Y.). The authors declare that they have no conflicts of interest with the contents of this article. Wu, Ping
291 42 p. 22288-22301
 article
15 Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity* * This work was supported by a Kennedy Trust for Rheumatology Research Doctoral Scholarship (to C. D.) and an Arthritis Research UK Career Development Fellowship (Grant 19466) (to L. T.). The work was additionally supported by the Arthritis Research UK Centre for Osteoarthritis Pathogenesis (Grant 20205); NIAMS, National Institutes of Health, Grant AR40994 (to H. N.); and NHLBI, National Institutes of Health, Grants HL114379 and HL120388 (to D. K. S.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Doherty, Christine M.
291 42 p. 22160-22172
 article
16 Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma* Wang, Zeneng
291 42 p. 22118-22135
 article
17 Ewing Tumor-associated Antigen 1 Interacts with Replication Protein A to Promote Restart of Stalled Replication Forks* * This work was supported in part by the National Basic Research Program of China Grant 2013CB911002 and the National Natural Science Foundation of China Grants 31271435 and 31370836. The authors declare that they have no conflicts of interest with the contents of this article. Feng, Sumin
291 42 p. 21956-21962
 article
18 Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth* * This work was supported in part by the Indiana CTSI Independent Scientist Award, Indiana CTSI Core awards, and the Showalter award (to S. R. N.) and National Institutes of Health Grant NS078008 (to N. B.). Hal Broxmeyer committed significant financial resources for completion of this project. The authors declare that they have no conflicts of interest with the content of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This article contains supplemental Figs. S1–S6. Lakhter, Alexander J.
291 42 p. 21869-21879
 article
19 Human DNA Ligase I Interacts with and Is Targeted for Degradation by the DCAF7 Specificity Factor of the Cul4-DDB1 Ubiquitin Ligase Complex* * This work was supported by the University of New Mexico Comprehensive Cancer Center (Grant P30 CA118100) and National Institute of Health Grant R01 GM057479 (to A. E. T.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Peng, Zhimin
291 42 p. 21893-21902
 article
20 Human Sex Determination at the Edge of Ambiguity Racca, Joseph D.
291 42 p. 22173-22195
 article
21 Hypoxia and Transforming Growth Factor β Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer* * This work was supported in part by American Cancer Society Grant RSG-10-244-01-CSM (to R. A. B.), the Joe and Jessie Crump Medical Research Foundation (to R. A. B.), National Institutes of Health Grants R01 CA118240 (to R. A. B.) and T32 GM008203 (to M. T.), and the Effie Marie Cain Scholarship in Angiogenesis Research (to R. A. B.). R. A. B. is a co-founder of Tuevol Therapeutics, a company that is developing therapeutics that target the tumor microenvironment. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Topalovski, Mary
291 42 p. 22244-22252
 article
22 Interdomain Conformational Changes Provide Allosteric Regulation en Route to Chorismate* * This work was supported by New Zealand Marsden Fund Grant UOC1105, the Biomolecular Interaction Centre, and the University of Canterbury High Performance Computing. The authors declare that they have no conflicts of interest with the contents of this article. ♦ ♦ This article was selected as a Paper of the Week. Nazmi, Ali Reza
291 42 p. 21836-21847
 article
23 Leptin Enhances TH2 and ILC2 Responses in Allergic Airway Disease* * This work was supported in part by National Institutes of Health Grants R56AI110442 and R56AI116772, American Lung Association Grant RG-268131, and UNM Cancer Center Pilot Award through contract National Institutes of Health Grant P30CA118100 (to X. O. Y.), and American Diabetes Association Junior Faculty Research Award 1-13-JF-37, American Heart Association Grant-in-Aid Award 15GRNT24940018, and CoBRE Pilot Award through National Institutes of Health Grant P30GM103400 and UNM RAC Pilot Awards (to M. L.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This article contains supplemental Figs. S1–S5. Zheng, Handong
291 42 p. 22043-22052
 article
24 Metformin Improves Metabolic Memory in High Fat Diet (HFD)-induced Renal Dysfunction* ♦ Tikoo, Kulbhushan
291 42 p. 21848-21856
 article
25 Mitochondrial localization of mutant superoxide dismutase 1 triggers caspase-dependent cell death in a cellular model of familial amyotrophic lateral sclerosis. Takeuchi, Hideyuki
291 42 p. 22341-22343
 article
26 New Helical Binding Domain Mediates a Glycosyltransferase Activity of a Bifunctional Protein* * This work was supported by National Institutes of Health NIDCR Grant R01DE17954 (to H. W.) and F33DE022215 (to H. W.), Biotechnology and Biological Sciences Research Council Grant BB/K016164/1, Core Support for Collaborative Research (to A. D. and S. M. H.), and a Wellcome Trust Senior Investigator Award (to A. D.). The authors declare no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This article contains supplemental Fig. S1. Zhang, Hua
291 42 p. 22106-22117
 article
27 N-terminal Prion Protein Peptides (PrP(120–144)) Form Parallel In-register β-Sheets via Multiple Nucleation-dependent Pathways* * This work was supported by National Institutes of Health Grants GM056766 and EB006006 and in part by National Science Foundation Research Triangle Materials Research Science and Engineering Centers (MRSEC) Grant DMR-1121107. The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This article contains supplemental Figs. S1–S6 and Table S1. Wang, Yiming
291 42 p. 22093-22105
 article
28 Pharmacological Chaperones of the Dopamine Transporter Rescue Dopamine Transporter Deficiency Syndrome Mutations in Heterologous Cells* * This work was supported by an ERA/MRI (Early Research Award/Ministry of Research and Innovation) Ontario grant (to A. S.). The authors declare that they have no conflicts of interest with the contents of this article. Beerepoot, Pieter
291 42 p. 22053-22062
 article
29 Pharmacological Correction of Trafficking Defects in ATP-sensitive Potassium Channels Caused by Sulfonylurea Receptor 1 Mutations* * This work was supported by National Institutes of Health Grants R01DK066485 (to S.-L. S.), F31DK105800 (to G. M. M.), R01DK098517 (to D. D. D. L.), and R37DK056268 (to C. A. S.) and a grant from the Goldsmith Foundation (to D. D. D. L. and C. A. S.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Martin, Gregory M.
291 42 p. 21971-21983
 article
30 Pigment Epithelium-derived Factor (PEDF) Blocks Wnt3a Protein-induced Autophagy in Pancreatic Intraepithelial Neoplasms* * This work was supported by National Institutes of Health Grant R21AA023607, National Institutes of Health Liver Center Core Grant DK34989, and a Veterans Affairs Merit Grant (to C. C.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Gong, Jingjing
291 42 p. 22074-22085
 article
31 Post-translational Acetylation of MbtA Modulates Mycobacterial Siderophore Biosynthesis* * This work was supported by National Institutes of Health Grants AI60899 (to J. S. B.) and AI26170, AI098925, and P01AI63537 (to W. R. J.). This research used resources of the Advanced Photon Source, a U.S. Department of Energy Office of Science User Facility operated for the Department of Energy Office of Science by Argonne National Laboratory under Contract DE-AC02-06CH11357. Use of the Lilly Research Laboratories Collaborative Access Team Beamline at Sector 31 of the Advanced Photon Source was provided by Eli Lilly Company, which operates the facility. The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Vergnolle, Olivia
291 42 p. 22315-22326
 article
32 Proof of Principle for a T Lymphocyte Intrinsic Function of Coronin 1A* * This work was supported by grants from the FWF Austrian Science Fund ”Lise-Meitner“ M1636-B23 (to K. S.) and 25044-B21 (to G. B.) and intramural funding program of the Medical University Innsbruck for young scientists MUI-START project 2013042002 (to K. S.). The authors declare that they have no conflicts of interest with the contents of this article. Siegmund, Kerstin
291 42 p. 22086-22092
 article
33 Pseudouridine in the Anticodon of Escherichia coli tRNATyr(QΨA) Is Catalyzed by the Dual Specificity Enzyme RluF* * This work was supported by NIGMS, National Institutes of Health Grant R01 GM 058843 (to P. A. L.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This article contains supplemental Tables S1–S3 and Figs. S1–S8. Addepalli, Balasubrahmanyam
291 42 p. 22327-22337
 article
34 Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells* * This work was supported, in whole or in part, by National Institutes of Health Grants R01 CA158275 (to P. A. C.) and R33 CA183685 (to K. C. H.). This work was also supported by Leukemia and Lymphoma Society Grants TRP 6230-11 and 6133-12 (to C. T. J.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This article contains supplemental Tables 1–8 and Figs. 1 and 2. Pei, Shanshan
291 42 p. 21984-22000
 article
35 Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors* * This work was supported by the National Heart Foundation of New Zealand (to H. A. W.), the School of Biological Sciences, University of Auckland seed fund (to H. A. W.), Grants BB/M00015X/1 (to G. L.), BB/M000176/1 (to D. R. P.), and BB/M006883/1 (to C. A. R.) from the BBSRC, BBSRC Doctoral Training Partnership Grant BB/JO14540/1 (to M. H.), MRC Doctoral Training Partnership MR/J003964/1 (to I. W.), the Warwick Impact Fund (to C. W. and G. L.), Grant RD13301 from the Warwick Research Development Fund (to C. W. and G. L.), and the Warwick Undergraduate Research Scholarship Scheme (to A. S. and R. H). The authors declare they have no conflicts of interest with the contents of this article. This article contains supplemental Movies 1 and 2. Weston, Cathryn
291 42 p. 21925-21944
 article
36 Regulation of Amyloid β Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex* * This work was supported by PrioNet-Canada, Canadian Institutes of Health Research (Grants MOP 93651, MOP 136930, MOP 126000, and MOP 89919), The Alzheimer's Association, the Canadian Foundation for Innovation, and the Ontario Research Fund (to M. A. M. P. and V. F. P.). This work was also supported by the Fundacao de Amparo a Pesquisa do Estado de Sao Paulo – FAPESP (to V. R. M) The authors declare that they have no conflicts of interest with the contents of this article. This article contains supplemental Figs. S1–S3 and supplemental Experimental Procedures. Beraldo, Flavio H.
291 42 p. 21945-21955
 article
37 Role of the Conserved Disulfide Bridge in Class A Carbapenemases* * This work was supported by National Institutes of Health Grant R01AI089726 (to S. B. V.). The SSRL Structural Molecular Biology Program is supported by the Department of Energy Office of Biological and Environmental Research and by the National Institutes of Health, National Institute of General Medical Sciences (including Grant P41GM103393). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This article contains supplemental Table S1. Smith, Clyde A.
291 42 p. 22196-22206
 article
38 Runt-related Transcription Factor 1 (RUNX1) Binds to p50 in Macrophages and Enhances TLR4-triggered Inflammation and Septic Shock* * This work was supported in part by Ministry of Science and Technology of China Grants 2016YFD05002007, 2016YFC0902200, and 2012CB910800, Strategic Priority Research Program of the Chinese Academy of Sciences Grant XDB19000000, National Natural Science Foundation of China Grants 81270801, 81470941, 31422018, 81571617, and 81570508, and Instrument Developing Project of the Chinese Academy of Sciences Grant YZ201339. The authors declare that they have no conflicts of interest with the contents of this article. This article contains supplemental Figs. S1–S9 and Tables S1–S5. Luo, Mao-Cai
291 42 p. 22011-22020
 article
39 Sintokamide A Is a Novel Antagonist of Androgen Receptor That Uniquely Binds Activation Function-1 in Its Amino-terminal Domain* * This work was supported by NCI, National Institutes of Health Grant 2R01CA105304 (to M. D. S.), Canadian Institutes of Health Research Grant MOP79308 (to M. D. S.), and Country Meadows Senior Men's Golf Charity Classic. C. A. B., N. R. M., J. W., R. J. A., and M. D. S. are shareholders of ESSA Pharma Inc. M. D. S. and R. J. A. receive compensation as consultants. M. D. S. and R. J. A. are Directors and Officers of ESSA Pharma Inc. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Banuelos, Carmen A.
291 42 p. 22231-22243
 article
40 Skeletal Muscle-specific G Protein-coupled Receptor Kinase 2 Ablation Alters Isolated Skeletal Muscle Mechanics and Enhances Clenbuterol-stimulated Hypertrophy* * This work was supported in part by National Institutes of Health Grant P01 HL091799. The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Woodall, Benjamin P.
291 42 p. 21913-21924
 article
41 Substrate Affinity Differentially Influences Protein Kinase C Regulation and Inhibitor Potency* * This work was supported in part by the American Heart Association Scientist Development Grant 13SDG14270009 and National Institutes of Health Grants 1DP2 CA186752-01 and 1-R01-GM-105646-01-A1 (to S. S.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Sommese, Ruth F.
291 42 p. 21963-21970
 article
42 The Mechanism by Which Arabinoxylanases Can Recognize Highly Decorated Xylans* * This work was supported in part by European Research Council Grant 322820 (to H. J. G. and B. H.), Biotechnology and Biological Research Council Grants BB/K020358/1 and BB/K001949/1 (to H. J. G.), Wellcome Trust Grant RES/0120/7613 (to H. J. G.), Agence Nationale de la Recherche Grant ANR 12-BIME-0006-01 (to B. H.), and Fundação para a Ciência e Tecnologia Grants PTDC/BIAPRO/103980/2008 and PTDC/BIAMIC/5947/2014 (to C. M. G. A. F.). The authors declare that they have no conflicts of interest with the contents of this article. This article contains supplemental Table S1 and Fig. S1. Labourel, Aurore
291 42 p. 22149-22159
 article
43 The N Terminus of the Prion Protein Mediates Functional Interactions with the Neuronal Cell Adhesion Molecule (NCAM) Fibronectin Domain* * This work was supported by the EC through FP7 222887 “Priority” (to G. L.). This work was also supported by a fellowship from the S.H.A.R.M. project (Supporting Human Assets in Research and Mobility, funded by the Friuli Venezia Giulia autonomous Region (Italy) through the Operational Program of the European Social Fund 2007/2013; Grant agreement number FP1123744003) (to G. G.), and by the Slovenian Research Agency (ARRS) Grant P1-242. The authors declare that they have no conflicts of interest with the contents of this article. This article contains supplemental Figs. S1 and S2. Slapšak, Urška
291 42 p. 21857-21868
 article
44 The Phospholipase Cγ2 Mutants R665W and L845F Identified in Ibrutinib-resistant Chronic Lymphocytic Leukemia Patients Are Hypersensitive to the Rho GTPase Rac2 Protein* * This work was supported by Grant SFB 1074, TP A8 from the Deutsche Forschungsgemeinschaft. The authors declare that they have no conflicts of interest with the contents of this article. Walliser, Claudia
291 42 p. 22136-22148
 article
45 Valproate Induces the Unfolded Protein Response by Increasing Ceramide Levels* * This work was supported by National Institutes of Health Grant DK081367 (to M. L. G.), the Swiss National Science Foundation (to R. S.), and the Graduate School of Wayne State University (to S. J.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This article contains supplemental Table 1. Jadhav, Shyamalagauri
291 42 p. 22253-22261
 article
46 Vesicle-associated Membrane Protein 3 (VAMP3) Mediates Constitutive Trafficking of the Renal Co-transporter NKCC2 in Thick Ascending Limbs Caceres, Paulo S.
291 42 p. 22063-22073
 article
47 Vtc5, a Novel Subunit of the Vacuolar Transporter Chaperone Complex, Regulates Polyphosphate Synthesis and Phosphate Homeostasis in Yeast* * This work was supported by European Research Council Grant 233458 and Schweizerischer Nationalfonds zur Förderung der Wissenschaften Grants 144258 and 163477/1 (to A. M.) and PP00P2-157607 (to H. J. J.). The authors declare that they have no conflicts of interest with the contents of this article. Desfougères, Yann
291 42 p. 22262-22275
 article
                             47 results found
 
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