nr |
titel |
auteur |
tijdschrift |
jaar |
jaarg. |
afl. |
pagina('s) |
type |
1 |
Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma
|
Wang, Pengyu |
|
|
|
9 |
p. 1396-1408.e8 |
artikel |
2 |
A chemogenetic platform for controlling plasma membrane signaling and synthetic signal oscillation
|
Suzuki, Sachio |
|
|
|
9 |
p. 1446-1464.e10 |
artikel |
3 |
Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound
|
Ehrnhoefer, Dagmar E. |
|
2019 |
|
9 |
p. 1295-1305.e6 |
artikel |
4 |
A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection
|
Vijayan, Kamalakannan |
|
|
|
9 |
p. 1419-1433.e5 |
artikel |
5 |
A MALDI-TOF Approach to Ubiquitin Ligase Activity
|
van Tol, Bianca D.M. |
|
2018 |
|
9 |
p. 1053-1055 |
artikel |
6 |
Anaerobic purinolytic enzymes enable dietary purine clearance by engineered gut bacteria
|
Tong, Yang |
|
|
|
9 |
p. 1104-1114.e7 |
artikel |
7 |
Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins
|
Pisa, Rudolf |
|
2019 |
|
9 |
p. 1263-1273.e5 |
artikel |
8 |
A New Staple: Peptide-Targeted Covalent Inhibitors
|
Leverson, Joel D. |
|
2016 |
|
9 |
p. 1043-1044 2 p. |
artikel |
9 |
An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals
|
Miller, Simon |
|
|
|
9 |
p. 1192-1198.e5 |
artikel |
10 |
A Plasma Protein Network Regulates PM20D1 and N-Acyl Amino Acid Bioactivity
|
Kim, Joon T. |
|
|
|
9 |
p. 1130-1139.e4 |
artikel |
11 |
Approaches and Guidelines for the Identification of Novel Substrates of Protein Lysine Methyltransferases
|
Kudithipudi, Srikanth |
|
2016 |
|
9 |
p. 1049-1055 7 p. |
artikel |
12 |
Approved Anti-cancer Drugs Target Oncogenic Non-coding RNAs
|
Velagapudi, Sai Pradeep |
|
2018 |
|
9 |
p. 1086-1094.e7 |
artikel |
13 |
A Quantitative Chemoproteomic Platform to Monitor Selenocysteine Reactivity within a Complex Proteome
|
Bak, Daniel W. |
|
2018 |
|
9 |
p. 1157-1167.e4 |
artikel |
14 |
A Rapid and Precise Mutation-Activated Fluorescence Reporter for Analyzing Acute Mutagenesis Frequency
|
Birnbaum, Michael D. |
|
|
|
9 |
p. 1220 |
artikel |
15 |
Biasing Opioid Receptors and Cholesterol as a Player in Developmental Biology
|
Kostic, Milka |
|
2016 |
|
9 |
p. 1039-1040 2 p. |
artikel |
16 |
Bioorthogonal dissection of the replicase assembly of hepatitis C virus
|
Zhang, Yang |
|
|
|
9 |
p. 1366-1378.e4 |
artikel |
17 |
Boosting glycolysis to combat fragile bone in type 1 diabetes
|
Jin, Zixue |
|
|
|
9 |
p. 1002-1003 |
artikel |
18 |
Break Away: FKBP12 sequestration as a target for increasing BMP activity
|
Taubert, Martha C. |
|
|
|
9 |
p. 1253-1255 |
artikel |
19 |
Bypassing Kinase Signaling in Mammalian Cells
|
Neumann, Heinz |
|
2018 |
|
9 |
p. 1051-1053 |
artikel |
20 |
Cell-free production of personalized therapeutic phages targeting multidrug-resistant bacteria
|
Emslander, Quirin |
|
|
|
9 |
p. 1434-1445.e7 |
artikel |
21 |
Challenges and opportunities in targeting metabolism
|
Birsoy, Kivanç |
|
|
|
9 |
p. 999-1001 |
artikel |
22 |
Chemical Biology as a Driver of Innovation in Cancer Research and Drug Discovery
|
Kostic, Milka |
|
2017 |
|
9 |
p. 1057- 1 p. |
artikel |
23 |
Chemical Inhibition of Protein Methyltransferases
|
Schapira, Matthieu |
|
2016 |
|
9 |
p. 1067-1076 10 p. |
artikel |
24 |
Chemical Targeting of a G-Quadruplex RNA in the Ebola Virus L Gene
|
Wang, Shao-Ru |
|
2016 |
|
9 |
p. 1113-1122 10 p. |
artikel |
25 |
Combined Proteomic and In Silico Target Identification Reveal a Role for 5-Lipoxygenase in Developmental Signaling Pathways
|
Brand, Silke |
|
2018 |
|
9 |
p. 1095-1106.e23 |
artikel |
26 |
Context-dependent regulation of ferroptosis sensitivity
|
Magtanong, Leslie |
|
|
|
9 |
p. 1409-1418.e6 |
artikel |
27 |
Cut it out! A CRISPR-Cas9 screen identifies host regulators of the Plasmodium liver stage
|
Chirgwin, Michael E. |
|
|
|
9 |
p. 1365-1367 |
artikel |
28 |
Defense Peptides Engineered from Human Platelet Factor 4 Kill Plasmodium by Selective Membrane Disruption
|
Lawrence, Nicole |
|
2018 |
|
9 |
p. 1140-1150.e5 |
artikel |
29 |
Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor
|
Skwarska, Anna |
|
|
|
9 |
p. 1258-1270.e13 |
artikel |
30 |
Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis
|
Zupancic, Jennifer M. |
|
|
|
9 |
p. 1379-1388.e7 |
artikel |
31 |
Discovery of a Novel DNA Gyrase-Targeting Antibiotic through the Chemical Perturbation of Streptomyces venezuelae Sporulation
|
McAuley, Scott |
|
2019 |
|
9 |
p. 1274-1282.e4 |
artikel |
32 |
Discovery of compounds that reactivate p53 mutants in vitro and in vivo
|
Durairaj, Geetha |
|
|
|
9 |
p. 1381-1395.e13 |
artikel |
33 |
Discovery of Druggable Host Factors Critical to Plasmodium Liver-Stage Infection
|
Raphemot, Rene |
|
2019 |
|
9 |
p. 1253-1262.e5 |
artikel |
34 |
Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters
|
Kang, Seong A. |
|
2019 |
|
9 |
p. 1203-1213.e13 |
artikel |
35 |
Divergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets
|
Sumi, Natalia J. |
|
2019 |
|
9 |
p. 1240-1252.e11 |
artikel |
36 |
Drug Discovery and Chemical Biology of Cancer Epigenetics
|
Ribich, Scott |
|
2017 |
|
9 |
p. 1120-1147 28 p. |
artikel |
37 |
Emerging Opportunities for Target Discovery in Rare Cancers
|
Sharifnia, Tanaz |
|
2017 |
|
9 |
p. 1075-1091 17 p. |
artikel |
38 |
Engineering Forward Genetics into Cultured Cancer Cells for Chemical Target Identification
|
Povedano, Juan Manuel |
|
2019 |
|
9 |
p. 1315-1321.e3 |
artikel |
39 |
Ferroptosis execution: Is it all about ACSL4?
|
Lee, Hyemin |
|
|
|
9 |
p. 1363-1365 |
artikel |
40 |
For Wnt Signaling, Fucosylation of LRP6 Is a Bitter Pill
|
Shami Shah, Adnan |
|
|
|
9 |
p. 1114-1116 |
artikel |
41 |
Fragment-linking peptide design yields a high-affinity ligand for microtubule-based transport
|
Cross, Jessica A. |
|
|
|
9 |
p. 1347-1355.e5 |
artikel |
42 |
From Catalytic Antibodies to Antibody-Drug Conjugates
|
Dimitrov, Dimiter S. |
|
2019 |
|
9 |
p. 1200-1201 |
artikel |
43 |
Genetic activation of glycolysis in osteoblasts preserves bone mass in type I diabetes
|
Ji, Xing |
|
|
|
9 |
p. 1053-1063.e5 |
artikel |
44 |
Genetically Encoded Protein Phosphorylation in Mammalian Cells
|
Beránek, Václav |
|
2018 |
|
9 |
p. 1067-1074.e5 |
artikel |
45 |
Glutamine availability unleashes dendritic cells’ anti-tumor power
|
Corrado, Mauro |
|
|
|
9 |
p. 1012-1014 |
artikel |
46 |
How Sweet It Is: Small-Molecule Inhibitors of mTORC1 Glucose Sensing
|
Zhang, Junbing |
|
2019 |
|
9 |
p. 1195-1196 |
artikel |
47 |
Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux
|
Spangenberg, Stephan H. |
|
|
|
9 |
p. 1115-1134.e10 |
artikel |
48 |
Hypoxia-activated KDAC inhibitor: Taking a breath from untargeted therapy
|
Staudt, Maximilian |
|
|
|
9 |
p. 1255-1257 |
artikel |
49 |
Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis
|
Hendricks, Joseph M. |
|
|
|
9 |
p. 1090-1103.e7 |
artikel |
50 |
Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System
|
Simpson, Luke M. |
|
|
|
9 |
p. 1164-1180.e5 |
artikel |
51 |
Inhibition of Bacterial Gene Transcription with an RpoN-Based Stapled Peptide
|
Payne, Sterling R. |
|
2018 |
|
9 |
p. 1059-1066.e4 |
artikel |
52 |
Inhibition of Glucose Transporters and Glutaminase Synergistically Impairs Tumor Cell Growth
|
Reckzeh, Elena S. |
|
2019 |
|
9 |
p. 1214-1228.e25 |
artikel |
53 |
Inhibition of Staphylococcus aureus biofilm-forming functional amyloid by molecular tweezers
|
Malishev, Ravit |
|
|
|
9 |
p. 1310-1320.e5 |
artikel |
54 |
In Situ Fucosylation of the Wnt Co-receptor LRP6 Increases Its Endocytosis and Reduces Wnt/β-Catenin Signaling
|
Hong, Senlian |
|
|
|
9 |
p. 1140-1150.e4 |
artikel |
55 |
Integrating inflammatory biomarker analysis and artificial-intelligence-enabled image-based profiling to identify drug targets for intestinal fibrosis
|
Yu, Shan |
|
|
|
9 |
p. 1169-1182.e8 |
artikel |
56 |
Integration of metabolism and regulation reveals rapid adaptability to growth on non-native substrates
|
Trivedi, Vikas D. |
|
|
|
9 |
p. 1135-1143.e5 |
artikel |
57 |
In This Issue
|
|
|
2016 |
|
9 |
p. v-vii nvt p. |
artikel |
58 |
In vivo drug discovery for increasing incretin-expressing cells identifies DYRK inhibitors that reinforce the enteroendocrine system
|
Chu, Lianhe |
|
|
|
9 |
p. 1368-1380.e5 |
artikel |
59 |
It Takes a Megalopolis to Relaunch a Journal: A Story of Gratitude
|
Kostic, Milka |
|
2016 |
|
9 |
p. 1037-1038 2 p. |
artikel |
60 |
Joining Forces: The Chemical Biology–Medicinal Chemistry Continuum
|
Plowright, Alleyn T. |
|
2017 |
|
9 |
p. 1058-1065 8 p. |
artikel |
61 |
Lipase Processing of Complex Lipid Antigens
|
Sander, Peter |
|
2016 |
|
9 |
p. 1044-1046 3 p. |
artikel |
62 |
Lysosomal Lipases PLRP2 and LPLA2 Process Mycobacterial Multi-acylated Lipids and Generate T Cell Stimulatory Antigens
|
Gilleron, Martine |
|
2016 |
|
9 |
p. 1147-1156 10 p. |
artikel |
63 |
Macrocyclic Peptide-Mediated Blockade of the CD47-SIRPα Interaction as a Potential Cancer Immunotherapy
|
Hazama, Daisuke |
|
|
|
9 |
p. 1181-1191.e7 |
artikel |
64 |
Mechanistic MALDI-TOF Cell-Based Assay for the Discovery of Potent and Specific Fatty Acid Synthase Inhibitors
|
Weigt, David |
|
2019 |
|
9 |
p. 1322-1331.e4 |
artikel |
65 |
Metabolic and chemical architecture of the mammalian circadian clock
|
Laothamatas, Isara |
|
|
|
9 |
p. 1033-1052 |
artikel |
66 |
Metabolic modulation of mitochondrial mass during CD4+ T cell activation
|
Kurmi, Kiran |
|
|
|
9 |
p. 1064-1075.e8 |
artikel |
67 |
Molecular basis of C-S bond cleavage in the glycyl radical enzyme isethionate sulfite-lyase
|
Dawson, Christopher D. |
|
|
|
9 |
p. 1333-1346.e7 |
artikel |
68 |
Networking in Circulation: Lipoproteins, PM20D1, and N-acyl Amino Acid Bioactivity
|
Saghatelian, Alan |
|
|
|
9 |
p. 1112-1113 |
artikel |
69 |
NREP contributes to development of NAFLD by regulating one-carbon metabolism in primary human hepatocytes
|
De Jesus, Dario F. |
|
|
|
9 |
p. 1144-1155.e4 |
artikel |
70 |
N-Thio-β-lactams targeting L,D-transpeptidase-2, with activity against drug-resistant strains of Mycobacterium tuberculosis
|
Martelli, Giulia |
|
|
|
9 |
p. 1321-1332.e5 |
artikel |
71 |
Parallel Glyco-SPOT Synthesis of Glycopeptide Libraries
|
Mehta, Akul Y. |
|
|
|
9 |
p. 1207-1219.e9 |
artikel |
72 |
Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury
|
Larraufie, Marie-Hélène |
|
|
|
9 |
p. 1271-1282.e12 |
artikel |
73 |
6-Phosphogluconate Dehydrogenase Links Cytosolic Carbohydrate Metabolism to Protein Secretion via Modulation of Glutathione Levels
|
Li, Haoxin |
|
2019 |
|
9 |
p. 1306-1314.e5 |
artikel |
74 |
Profiling Substrate Promiscuity of Wild-Type Sugar Kinases for Multi-fluorinated Monosaccharides
|
Keenan, Tessa |
|
|
|
9 |
p. 1199-1206.e5 |
artikel |
75 |
Protein acylation by saturated very long chain fatty acids and endocytosis are involved in necroptosis
|
Pradhan, Apoorva J. |
|
|
|
9 |
p. 1298-1309.e7 |
artikel |
76 |
Regulation of Autophagic Flux by the 20S Proteasome
|
Njomen, Evert |
|
2019 |
|
9 |
p. 1283-1294.e5 |
artikel |
77 |
Regulation of the endocytosis and prion-chaperoning machineries by yeast E3 ubiquitin ligase Rsp5 as revealed by orthogonal ubiquitin transfer
|
Wang, Yiyang |
|
|
|
9 |
p. 1283-1297.e8 |
artikel |
78 |
Remembering Professor Amy Christine Anderson
|
Schiffer, Celia |
|
2016 |
|
9 |
p. 1041-1042 2 p. |
artikel |
79 |
Repurposing SGLT2 inhibitors for autoimmune diseases? YES, WE MAY!
|
Certo, Michelangelo |
|
|
|
9 |
p. 1009-1011 |
artikel |
80 |
Resistance to Enediyne Antitumor Antibiotics by Sequestration
|
Chang, Chin-Yuan |
|
2018 |
|
9 |
p. 1075-1085.e4 |
artikel |
81 |
Sabotaging the breaks: FSEN1 expands the toolbox of FSP1 inhibitors
|
Xavier da Silva, Thamara Nishida |
|
|
|
9 |
p. 1006-1008 |
artikel |
82 |
Screening in serum-derived medium reveals differential response to compounds targeting metabolism
|
Abbott, Keene L. |
|
|
|
9 |
p. 1156-1168.e7 |
artikel |
83 |
Selective Covalent Targeting of Anti-Apoptotic BFL-1 by Cysteine-Reactive Stapled Peptide Inhibitors
|
Huhn, Annissa J. |
|
2016 |
|
9 |
p. 1123-1134 12 p. |
artikel |
84 |
Sequencing Mirror-Image DNA Chemically
|
Liu, Xianyu |
|
2018 |
|
9 |
p. 1151-1156.e3 |
artikel |
85 |
Site-Selective Antibody Functionalization via Orthogonally Reactive Arginine and Lysine Residues
|
Hwang, Dobeen |
|
2019 |
|
9 |
p. 1229-1239.e9 |
artikel |
86 |
Small-Molecule Inhibitors Targeting DNA Repair and DNA Repair Deficiency in Research and Cancer Therapy
|
Hengel, Sarah R. |
|
2017 |
|
9 |
p. 1101-1119 19 p. |
artikel |
87 |
Small-molecule MHC-II inducers promote immune detection and anti-cancer immunity via editing cancer metabolism
|
Huang, Ling |
|
|
|
9 |
p. 1076-1089.e11 |
artikel |
88 |
Small-Molecule Protein-Protein Interaction Inhibitor of Oncogenic Rho Signaling
|
Diviani, Dario |
|
2016 |
|
9 |
p. 1135-1146 12 p. |
artikel |
89 |
Small-Molecule Targets in Immuno-Oncology
|
Dhanak, Dashyant |
|
2017 |
|
9 |
p. 1148-1160 13 p. |
artikel |
90 |
Small Substrate or Large? Debate Over the Mechanism of Glycation Adduct Repair by DJ-1
|
Jun, Yong Woong |
|
|
|
9 |
p. 1117-1123 |
artikel |
91 |
Spliceostatin A interaction with SF3B limits U1 snRNP availability and causes premature cleavage and polyadenylation
|
Yoshimoto, Rei |
|
|
|
9 |
p. 1356-1365.e4 |
artikel |
92 |
Stabilizing Protein Motifs with a Genetically Encoded Metal-Ion Chelator
|
Luo, Xiaozhou |
|
2016 |
|
9 |
p. 1098-1102 5 p. |
artikel |
93 |
Starving the Devourer: Cutting Cancer Off from Its Favorite Foods
|
Katt, William P. |
|
2019 |
|
9 |
p. 1197-1199 |
artikel |
94 |
Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles
|
Aleem, Saadat U. |
|
2016 |
|
9 |
p. 1103-1112 10 p. |
artikel |
95 |
Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop “Out” Conformation for LasR
|
O'Reilly, Matthew C. |
|
2018 |
|
9 |
p. 1128-1139.e3 |
artikel |
96 |
Structural Insights into Mitochondrial Calcium Uniporter Regulation by Divalent Cations
|
Lee, Samuel K. |
|
2016 |
|
9 |
p. 1157-1169 13 p. |
artikel |
97 |
Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate
|
Schäfer, Martin |
|
2016 |
|
9 |
p. 1091-1097 7 p. |
artikel |
98 |
Synthetic Biology-Based Point-of-Care Diagnostics for Infectious Disease
|
Wei, Ting-Yen |
|
2016 |
|
9 |
p. 1056-1066 11 p. |
artikel |
99 |
Systematic Chemogenetic Library Assembly
|
Canham, Stephen M. |
|
|
|
9 |
p. 1124-1129 |
artikel |
100 |
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
|
Cromm, Philipp M. |
|
2017 |
|
9 |
p. 1181-1190 10 p. |
artikel |
101 |
Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System
|
Röth, Sascha |
|
|
|
9 |
p. 1151-1163.e6 |
artikel |
102 |
Targeting Metabolism for Cancer Therapy
|
Luengo, Alba |
|
2017 |
|
9 |
p. 1161-1180 20 p. |
artikel |
103 |
Targeting Nucleoporin POM121-Importin β Axis in Prostate Cancer
|
Lim, Kee Siang |
|
2018 |
|
9 |
p. 1056-1058 |
artikel |
104 |
The Emerging Role of RNA as a Therapeutic Target for Small Molecules
|
Connelly, Colleen M. |
|
2016 |
|
9 |
p. 1077-1090 14 p. |
artikel |
105 |
The MALDI-TOF E2/E3 Ligase Assay as Universal Tool for Drug Discovery in the Ubiquitin Pathway
|
De Cesare, Virginia |
|
2018 |
|
9 |
p. 1117-1127.e4 |
artikel |
106 |
The Meisenheimer Complex as a Paradigm in Drug Discovery: Reversible Covalent Inhibition through C67 of the ATP Binding Site of PLK1
|
Pearson, Russell J. |
|
2018 |
|
9 |
p. 1107-1116.e4 |
artikel |
107 |
The Pursuit of Therapeutic Biomarkers with High-Throughput Cancer Cell Drug Screens
|
Williams, Steven P. |
|
2017 |
|
9 |
p. 1066-1074 9 p. |
artikel |
108 |
Tumor microenvironmental nutrients, cellular responses, and cancer
|
Lobel, Graham P. |
|
|
|
9 |
p. 1015-1032 |
artikel |
109 |
Tumor Organoids as a Pre-clinical Cancer Model for Drug Discovery
|
Weeber, Fleur |
|
2017 |
|
9 |
p. 1092-1100 9 p. |
artikel |
110 |
Un-FASN-ing cancer’s seat belt: Linking lipid metabolism and antigen presentation
|
Corey, Zachary |
|
|
|
9 |
p. 1004-1006 |
artikel |
111 |
Vaccinology Gets Help from Chemistry
|
Adamo, Roberto |
|
2016 |
|
9 |
p. 1047-1048 2 p. |
artikel |
112 |
Winding Down: Selectively Drugging a Promiscuous Pocket in Cryptochrome Slows Circadian Rhythms
|
Crane, Brian R. |
|
|
|
9 |
p. 1109-1111 |
artikel |