| no |
title |
author |
magazine |
year |
volume |
issue |
page(s) |
type |
| 1 |
A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biological activities
|
Shao, Hao
|
|
|
|
8 |
p. 1303-1316.e3
|
article
|
| 2 |
Activity-Based Profiling Reveals a Regulatory Link between Oxidative Stress and Protein Arginine Phosphorylation
|
Fuhrmann, Jakob
|
|
2016
|
|
8 |
p. 967-977
11 p.
|
article
|
| 3 |
Acylation probing of “generic” RNA libraries reveals critical influence of loop constraints on reactivity
|
Xiao, Lu
|
|
|
|
8 |
p. 1341-1352.e8
|
article
|
| 4 |
Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death
|
Wong, Keith S.
|
|
|
|
8 |
p. 1017-1030.e9
|
article
|
| 5 |
Addressable Cholesterol Analogs for Live Imaging of Cellular Membranes
|
Rakers, Lena
|
|
|
|
8 |
p. 952-961.e12
|
article
|
| 6 |
A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader
|
Payne, N. Connor
|
|
|
|
8 |
p. 1333-1340.e5
|
article
|
| 7 |
A Fungal-Selective Cytochrome bc 1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance
|
Vincent, Benjamin M.
|
|
2016
|
|
8 |
p. 978-991
14 p.
|
article
|
| 8 |
Aggregation and Its Influence on the Immunomodulatory Activity of Synthetic Innate Defense Regulator Peptides
|
Haney, Evan F.
|
|
2017
|
|
8 |
p. 969-980.e4
|
article
|
| 9 |
Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma
|
Ferguson, Ian D.
|
|
|
|
8 |
p. 1288-1302.e7
|
article
|
| 10 |
Amine Landscaping to Maximize Protein-Dye Fluorescence and Ultrastable Protein-Ligand Interaction
|
Jacobsen, Michael T.
|
|
2017
|
|
8 |
p. 1040-1047.e4
|
article
|
| 11 |
An antitubercular prodrug leaves Mycobacterium tuberculosis facing a difficult choice, poisoning or starvation?
|
Jackson, Mary
|
|
|
|
8 |
p. 1101-1103
|
article
|
| 12 |
A non-rational approach to optimized targeting of CRISPR-Cas9 complexes
|
Wilbanks, Brandon
|
|
|
|
8 |
p. 855-857
|
article
|
| 13 |
A Photo-clickable ATP-Mimetic Reveals Nucleotide Interactors in the Membrane Proteome
|
Jelcic, Mark
|
|
|
|
8 |
p. 1073-1083.e12
|
article
|
| 14 |
A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants
|
Schenkel, Laurie B.
|
|
|
|
8 |
p. 1158-1168.e13
|
article
|
| 15 |
A Rapid and Precise Mutation-Activated Fluorescence Reporter for Analyzing Acute Mutagenesis Frequency
|
Birnbaum, Michael D.
|
|
|
|
8 |
p. 1038-1049.e5
|
article
|
| 16 |
A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex
|
Chatrikhi, Rakesh
|
|
|
|
8 |
p. 1145-1157.e6
|
article
|
| 17 |
A Systems Pharmacology Approach Uncovers Wogonoside as an Angiogenesis Inhibitor of Triple-Negative Breast Cancer by Targeting Hedgehog Signaling
|
Huang, Yujie
|
|
2019
|
|
8 |
p. 1143-1158.e6
|
article
|
| 18 |
Basis of Mutual Domain Inhibition in a Bacterial Response Regulator
|
Corrêa, Fernando
|
|
2016
|
|
8 |
p. 945-954
10 p.
|
article
|
| 19 |
Binding between G Quadruplexes at the Homodimer Interface of the Corn RNA Aptamer Strongly Activates Thioflavin T Fluorescence
|
Sjekloća, Ljiljana
|
|
2019
|
|
8 |
p. 1159-1168.e4
|
article
|
| 20 |
Bioreporters for direct mode of action-informed screening of antibiotic producer strains
|
Wex, Katharina W.
|
|
|
|
8 |
p. 1242-1252.e4
|
article
|
| 21 |
Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis
|
Zhang, Qian
|
|
|
|
8 |
p. 1248-1259.e6
|
article
|
| 22 |
Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions
|
Dietrich, Laura
|
|
2017
|
|
8 |
p. 958-968.e5
|
article
|
| 23 |
Chemical Biology Interrogates Protein Arginine Phosphorylation
|
Suskiewicz, Marcin Józef
|
|
2016
|
|
8 |
p. 888-890
3 p.
|
article
|
| 24 |
Chemical Biology Toolbox for Studying Pancreatic Islet Function – A Perspective
|
Huey, Julia
|
|
|
|
8 |
p. 1015-1031
|
article
|
| 25 |
Chemical Biology Tools for Examining the Bacterial Cell Wall
|
Brown, Ashley R.
|
|
|
|
8 |
p. 1052-1062
|
article
|
| 26 |
Chemical Modulation of Cell Fate in Stem Cell Therapeutics and Regenerative Medicine
|
Liu, Kai
|
|
2016
|
|
8 |
p. 893-916
24 p.
|
article
|
| 27 |
Chemical Tools for Endogenous Protein Labeling and Profiling
|
Shiraiwa, Kazuki
|
|
|
|
8 |
p. 970-985
|
article
|
| 28 |
Chemical Tools in Biological Discovery
|
Dey, Mishtu
|
|
|
|
8 |
p. 889-890
|
article
|
| 29 |
Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation
|
Goth, Christoffer K.
|
|
|
|
8 |
p. 893-905.e7
|
article
|
| 30 |
Construction of Fluorescent Analogs to Follow the Uptake and Distribution of Cobalamin (Vitamin B12) in Bacteria, Worms, and Plants
|
Lawrence, Andrew D.
|
|
|
|
8 |
p. 941-951.e6
|
article
|
| 31 |
Convergent Use of Heptacoordination for Cation Selectivity by RNA and Protein Metalloregulators
|
Bachas, Sharrol T.
|
|
|
|
8 |
p. 962-973.e5
|
article
|
| 32 |
Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes
|
Poreba, Marcin
|
|
2016
|
|
8 |
p. 1023-1035
13 p.
|
article
|
| 33 |
Deciphering Carbamoylpolyoxamic Acid Biosynthesis Reveals Unusual Acetylation Cycle Associated with Tandem Reduction and Sequential Hydroxylation
|
Qi, Jianzhao
|
|
2016
|
|
8 |
p. 935-944
10 p.
|
article
|
| 34 |
DELs enable the development of BRET probes for target engagement studies in cells
|
Teske, Kelly A.
|
|
|
|
8 |
p. 987-998.e24
|
article
|
| 35 |
Dual pH/Activity Probes Expand the Cathepsin Toolkit
|
Shin, Sunny
|
|
2016
|
|
8 |
p. 891-892
2 p.
|
article
|
| 36 |
Dysregulating ClpP: From Antibiotics to Anticancer?
|
Dougan, David A.
|
|
|
|
8 |
p. 929-930
|
article
|
| 37 |
Fatty acid chain length drives lysophosphatidylserine-dependent immunological outputs
|
Khandelwal, Neha
|
|
|
|
8 |
p. 1169-1179.e6
|
article
|
| 38 |
Fighting Kinase Drug Resistance with Caspase Activators
|
Hardy, Jeanne A.
|
|
|
|
8 |
p. 927-928
|
article
|
| 39 |
From Powerful Review Articles to Research Breakthroughs
|
Kostic, Milka
|
|
2016
|
|
8 |
p. 883-884
2 p.
|
article
|
| 40 |
Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth
|
Müller, Martin
|
|
|
|
8 |
p. 1119-1131.e27
|
article
|
| 41 |
Generation of glycan-specific nanobodies
|
Khilji, Sana Khan
|
|
|
|
8 |
p. 1353-1361.e6
|
article
|
| 42 |
Genome- and metabolome-guided discovery of marine BamA inhibitors revealed a dedicated darobactin halogenase
|
Böhringer, Nils
|
|
|
|
8 |
p. 943-952.e7
|
article
|
| 43 |
Genome editor-directed in vivo library diversification
|
Cheng, Cristina
|
|
|
|
8 |
p. 1109-1118
|
article
|
| 44 |
Global Cysteine-Reactivity Profiling during Impaired Insulin/IGF-1 Signaling in C. elegans Identifies Uncharacterized Mediators of Longevity
|
Martell, Julianne
|
|
2016
|
|
8 |
p. 955-966
12 p.
|
article
|
| 45 |
Help! I need a WNT antibody. Help! Not just any antibody
|
Maimets, Martti
|
|
|
|
8 |
p. 857-860
|
article
|
| 46 |
Illuminating RNA Biology: Tools for Imaging RNA in Live Mammalian Cells
|
Braselmann, Esther
|
|
|
|
8 |
p. 891-903
|
article
|
| 47 |
Improved ThwaRTing of Genome Symbionts
|
Goodier, John L.
|
|
2019
|
|
8 |
p. 1043-1045
|
article
|
| 48 |
In-depth characterization of ubiquitin turnover in mammalian cells by fluorescence tracking
|
Kudriaeva, Anna A.
|
|
|
|
8 |
p. 1192-1205.e9
|
article
|
| 49 |
Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein
|
de Wispelaere, Melissanne
|
|
|
|
8 |
p. 1006-1016.e8
|
article
|
| 50 |
Inhibition of nucleolar transcription by oxaliplatin involves ATM/ATR kinase signaling
|
Nechay, Misha
|
|
|
|
8 |
p. 906-919.e4
|
article
|
| 51 |
Inside Job: Methods for Delivering Proteins to the Interior of Mammalian Cells
|
Bruce, Virginia J.
|
|
2017
|
|
8 |
p. 924-934
|
article
|
| 52 |
Insulin sensitization by small molecules enhancing GLUT4 translocation
|
Yin, Terry C.
|
|
|
|
8 |
p. 933-942.e6
|
article
|
| 53 |
In This Issue
|
|
|
2016
|
|
8 |
p. v-vii
nvt p.
|
article
|
| 54 |
Introduction to Thiopeptides: Biological Activity, Biosynthesis, and Strategies for Functional Reprogramming
|
Vinogradov, Alexander A.
|
|
|
|
8 |
p. 1032-1051
|
article
|
| 55 |
Ketone Body Acetoacetate Buffers Methylglyoxal via a Non-enzymatic Conversion during Diabetic and Dietary Ketosis
|
Salomón, Trine
|
|
2017
|
|
8 |
p. 935-943.e7
|
article
|
| 56 |
Lanthanide-Based Optical Probes of Biological Systems
|
Cho, Ukrae
|
|
|
|
8 |
p. 921-936
|
article
|
| 57 |
Lenalidomide bypasses CD28 co-stimulation to reinstate PD-1 immunotherapy by activating Notch signaling
|
Geng, Chen-Lu
|
|
|
|
8 |
p. 1260-1272.e8
|
article
|
| 58 |
Mitochondrial Chemical Biology: New Probes Elucidate the Secrets of the Powerhouse of the Cell
|
Wisnovsky, Simon
|
|
2016
|
|
8 |
p. 917-927
11 p.
|
article
|
| 59 |
Mitochondria-targeted melatonin photorelease supports the presence of melatonin MT1 receptors in mitochondria inhibiting respiration
|
Somalo-Barranco, Gloria
|
|
|
|
8 |
p. 920-932.e7
|
article
|
| 60 |
Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS
|
Narvaez, Ana J.
|
|
2017
|
|
8 |
p. 1017-1028.e7
|
article
|
| 61 |
Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity
|
Hafner, Marc
|
|
2019
|
|
8 |
p. 1067-1080.e8
|
article
|
| 62 |
Novel Frizzled-specific antibody-based Wnt mimetics and Wnt superagonists selectively activate WNT/β-catenin signaling in target tissues
|
Post, Yorick
|
|
|
|
8 |
p. 976-986.e5
|
article
|
| 63 |
Optimized Streptavidin for Fluorescent Labeling of Biotinylated Targets
|
Hytönen, Vesa P.
|
|
2017
|
|
8 |
p. 921-922
|
article
|
| 64 |
OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity
|
Rovira, Xavier
|
|
2016
|
|
8 |
p. 929-934
6 p.
|
article
|
| 65 |
Overcoming Resistance to Targeted Anticancer Therapies through Small-Molecule-Mediated MEK Degradation
|
Peh, Jessie
|
|
|
|
8 |
p. 996-1005.e4
|
article
|
| 66 |
Parallel Chemoselective Profiling for Mapping Protein Structure
|
Potter, Zachary E.
|
|
|
|
8 |
p. 1084-1096.e4
|
article
|
| 67 |
Paralog-dependent isogenic cell assay cascade generates highly selective SLC16A3 inhibitors
|
Dvorak, Vojtech
|
|
|
|
8 |
p. 953-964.e9
|
article
|
| 68 |
Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin
|
Zhu, Huifang
|
|
2019
|
|
8 |
p. 1122-1132.e6
|
article
|
| 69 |
Pharmacological perturbation of thiamine metabolism sensitizes Pseudomonas aeruginosa to multiple antibacterial agents
|
Kim, Hyung Jun
|
|
|
|
8 |
p. 1317-1324.e5
|
article
|
| 70 |
Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C
|
Zeng, Mei
|
|
2017
|
|
8 |
p. 1005-1016.e3
|
article
|
| 71 |
Principles of Chemical Biology: Iron and CSCs, Histone Acylation sans Enzymes, Eliciting Silent Gene Clusters, and 2′-deoxy-ADPR as a Second Messenger
|
|
|
2017
|
|
8 |
p. 919-920
|
article
|
| 72 |
Programming Cell-Cell Interactions through Non-genetic Membrane Engineering
|
Csizmar, Clifford M.
|
|
|
|
8 |
p. 931-940
|
article
|
| 73 |
PROTACs: An Emerging Therapeutic Modality in Precision Medicine
|
Nalawansha, Dhanusha A.
|
|
|
|
8 |
p. 998-1014
|
article
|
| 74 |
Protein Acylation is a General Regulatory Mechanism in Biosynthetic Pathway of Acyl-CoA-Derived Natural Products
|
Xu, Jun-Yu
|
|
|
|
8 |
p. 984-995.e6
|
article
|
| 75 |
Quinoline Derivatives Kill Mycobacterium tuberculosis by Activating Glutamate Kinase
|
Makafe, Gaelle G.
|
|
2019
|
|
8 |
p. 1187-1194.e5
|
article
|
| 76 |
Rapid Screening and Identification of Living Pathogenic Organisms via Optimized Bioorthogonal Non-canonical Amino Acid Tagging
|
Sherratt, Allison Rae
|
|
2017
|
|
8 |
p. 1048-1055.e3
|
article
|
| 77 |
Rational Design of Bioavailable Photosensitizers for Manipulation and Imaging of Biological Systems
|
Binns, Thomas C.
|
|
|
|
8 |
p. 1063-1072.e7
|
article
|
| 78 |
Repurposing of glycine transport inhibitors for the treatment of erythropoietic protoporphyria
|
Halloy, François
|
|
|
|
8 |
p. 1221-1234.e6
|
article
|
| 79 |
Repurposing the repurposed: thalidomide analogs as immune stimulants to overcome T cell exhaustion
|
Słabicki, Mikołaj
|
|
|
|
8 |
p. 1245-1247
|
article
|
| 80 |
Resistance of Mycobacterium tuberculosis to indole 4-carboxamides occurs through alterations in drug metabolism and tryptophan biosynthesis
|
Libardo, M. Daben J.
|
|
|
|
8 |
p. 1180-1191.e20
|
article
|
| 81 |
RIBOTACs: Small Molecules Target RNA for Degradation
|
Dey, Sourav K.
|
|
2019
|
|
8 |
p. 1047-1049
|
article
|
| 82 |
Scribble sub-cellular localization modulates recruitment of YES1 to regulate YAP1 phosphorylation
|
Zhao, Dongyu
|
|
|
|
8 |
p. 1235-1241.e5
|
article
|
| 83 |
Seeing (and Using) the Light: Recent Developments in Bioluminescence Technology
|
Love, Anna C.
|
|
|
|
8 |
p. 904-920
|
article
|
| 84 |
Selective Modulation of Dynamic Protein Complexes
|
Garlick, Julie M.
|
|
|
|
8 |
p. 986-997
|
article
|
| 85 |
Shedding Light on Metabotropic Glutamate Receptors
|
Nicoletti, Ferdinando
|
|
2016
|
|
8 |
p. 887-888
2 p.
|
article
|
| 86 |
Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death
|
Song, Jin H.
|
|
2019
|
|
8 |
p. 1110-1121.e4
|
article
|
| 87 |
S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons
|
Doulias, Paschalis-Thomas
|
|
|
|
8 |
p. 965-975.e6
|
article
|
| 88 |
S1PR3–G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation
|
Toyomoto, Masayasu
|
|
|
|
8 |
p. 1132-1144.e9
|
article
|
| 89 |
Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy
|
Young, Zapporah T.
|
|
2016
|
|
8 |
p. 992-1001
10 p.
|
article
|
| 90 |
Stem Cell Hydrogel, Jump-Starting Zika Drug Discovery, and Engineering RNA Recognition
|
Kostic, Milka
|
|
2016
|
|
8 |
p. 885-886
2 p.
|
article
|
| 91 |
Strategies for Tuning the Selectivity of Chemical Probes that Target Serine Hydrolases
|
Faucher, Franco
|
|
|
|
8 |
p. 937-952
|
article
|
| 92 |
Structure-based Engineering of a Plant-Fungal Hybrid Peroxidase for Enhanced Temperature and pH Tolerance
|
Kohler, Amanda C.
|
|
|
|
8 |
p. 974-983.e3
|
article
|
| 93 |
Structure-Based Identification of a Potent Inhibitor Targeting Stp1-Mediated Virulence Regulation in Staphylococcus aureus
|
Zheng, Weihao
|
|
2016
|
|
8 |
p. 1002-1013
12 p.
|
article
|
| 94 |
Stuck on UUUU: New splicing inhibitors enhance U2AF2-RNA binding
|
Love, Sierra L.
|
|
|
|
8 |
p. 1106-1108
|
article
|
| 95 |
Switching Off Cancer-Causing Telomerase Using Small Molecules
|
Asamitsu, Sefan
|
|
2019
|
|
8 |
p. 1045-1047
|
article
|
| 96 |
Synthesis and Characterization of Specific Reverse Transcriptase Inhibitors for Mammalian LINE-1 Retrotransposons
|
Banuelos-Sanchez, Guillermo
|
|
2019
|
|
8 |
p. 1095-1109.e14
|
article
|
| 97 |
Synthetic Lipoteichoic Acid Glycans Are Potential Vaccine Candidates to Protect from Clostridium difficile Infections
|
Broecker, Felix
|
|
2016
|
|
8 |
p. 1014-1022
9 p.
|
article
|
| 98 |
Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease
|
Totzke, Juliane
|
|
2017
|
|
8 |
p. 1029-1039.e7
|
article
|
| 99 |
Targeted Covalent Inhibition of Prolyl Oligopeptidase (POP): Discovery of Sulfonylfluoride Peptidomimetics
|
Guardiola, Salvador
|
|
|
|
8 |
p. 1031-1037.e4
|
article
|
| 100 |
Targeted Degradation of a Hypoxia-Associated Non-coding RNA Enhances the Selectivity of a Small Molecule Interacting with RNA
|
Costales, Matthew G.
|
|
2019
|
|
8 |
p. 1180-1186.e5
|
article
|
| 101 |
Targeting Mycobacterium tuberculosis Sensitivity to Thiol Stress at Acidic pH Kills the Bacterium and Potentiates Antibiotics
|
Coulson, Garry B.
|
|
2017
|
|
8 |
p. 993-1004.e4
|
article
|
| 102 |
Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells
|
Mehta, Stuti
|
|
|
|
8 |
p. 1273-1287.e8
|
article
|
| 103 |
The Chemical Biology of Reversible Lysine Post-translational Modifications
|
Wang, Zhipeng A.
|
|
|
|
8 |
p. 953-969
|
article
|
| 104 |
The Convergence of Stem Cell Technologies and Phenotypic Drug Discovery
|
Friese, Alexandra
|
|
2019
|
|
8 |
p. 1050-1066
|
article
|
| 105 |
The dark side of circular RNA, a new driver of genome instability
|
Sharma, Ajit Kumar
|
|
|
|
8 |
p. 861-863
|
article
|
| 106 |
The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines
|
Gardner, Nicola J.
|
|
2017
|
|
8 |
p. 981-992.e4
|
article
|
| 107 |
The Natural Product Butylcycloheptyl Prodiginine Binds Pre-miR-21, Inhibits Dicer-Mediated Processing of Pre-miR-21, and Blocks Cellular Proliferation
|
Matarlo, Joe S.
|
|
2019
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