| nr |
titel |
auteur |
tijdschrift |
jaar |
jaarg. |
afl. |
pagina('s) |
type |
| 1 |
A Bacterial Expression Platform for Production of Therapeutic Proteins Containing Human-like O-Linked Glycans
|
Du, Ting
|
|
2019
|
|
2 |
p. 203-212.e5
|
artikel
|
| 2 |
A bidirectional link between sulfatide and Alzheimer’s disease
|
Zimmer, Valerie Christin
|
|
|
|
2 |
p. 265-283.e7
|
artikel
|
| 3 |
A Bump-Hole Approach for Directed RNA Editing
|
Monteleone, Leanna R.
|
|
2019
|
|
2 |
p. 269-277.e5
|
artikel
|
| 4 |
Accurate Prediction of Ligand Affinities for a Proton-Dependent Oligopeptide Transporter
|
Samsudin, Firdaus
|
|
2016
|
|
2 |
p. 299-309
|
artikel
|
| 5 |
A Chemical Screen Identifies Compounds Limiting the Toxicity of C9ORF72 Dipeptide Repeats
|
Corman, Alba
|
|
2019
|
|
2 |
p. 235-243.e5
|
artikel
|
| 6 |
Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme
|
Li, Yi-Jia
|
|
2019
|
|
2 |
p. 278-288.e6
|
artikel
|
| 7 |
All the mutations that are fit to die
|
Gebauer, Emma
|
|
|
|
2 |
p. 192-194
|
artikel
|
| 8 |
A Master Switch in Thiopeptide Biosynthesis
|
Roessler, Claudia
|
|
2018
|
|
2 |
p. 121-123
|
artikel
|
| 9 |
An affinity-directed phosphatase, AdPhosphatase, system for targeted protein dephosphorylation
|
Simpson, Luke M.
|
|
|
|
2 |
p. 188-202.e6
|
artikel
|
| 10 |
A Natural Product Puts Malaria on a Low-Fat Diet
|
Lucy, Daniel
|
|
|
|
2 |
p. 137-139
|
artikel
|
| 11 |
Ancestral Protein Reconstruction Yields Insights into Adaptive Evolution of Binding Specificity in Solute-Binding Proteins
|
Clifton, Ben E.
|
|
2016
|
|
2 |
p. 236-245
|
artikel
|
| 12 |
Antiplasmodial peptaibols act through membrane directed mechanisms
|
Collins, Jennifer E.
|
|
|
|
2 |
p. 312-325.e9
|
artikel
|
| 13 |
Antitubercular Triazines: Optimization and Intrabacterial Metabolism
|
Wang, Xin
|
|
|
|
2 |
p. 172-185.e11
|
artikel
|
| 14 |
An Unusual Protector-Protégé Strategy for the Biosynthesis of Purine Nucleoside Antibiotics
|
Wu, Pan
|
|
2017
|
|
2 |
p. 171-181
|
artikel
|
| 15 |
A Prob(e)able Route to Lysine Acylation
|
Wagner, Gregory R.
|
|
2017
|
|
2 |
p. 126-128
|
artikel
|
| 16 |
Aptamers as Reversible Sorting Ligands for Preparation of Cells in Their Native State
|
Gray, Bethany Powell
|
|
|
|
2 |
p. 232-244.e7
|
artikel
|
| 17 |
Arabidopsis P-Glycoprotein19 Participates in the Inhibition of Gravitropism by Gravacin
|
Rojas-Pierce, Marcela
|
|
|
|
2 |
p. 242
|
artikel
|
| 18 |
A Robust, GFP-Orthogonal Photoswitchable Inhibitor Scaffold Extends Optical Control over the Microtubule Cytoskeleton
|
Gao, Li
|
|
|
|
2 |
p. 228-241.e6
|
artikel
|
| 19 |
A Strategic Approach for Fluorescence Imaging of Membrane Proteins in a Native-like Environment
|
Swiecicki, Jean-Marie
|
|
|
|
2 |
p. 245-251.e3
|
artikel
|
| 20 |
A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype
|
Haniff, Hafeez S.
|
|
|
|
2 |
p. 300-311.e10
|
artikel
|
| 21 |
A SUMO1-Derived Peptide Targeting SUMO-Interacting Motif Inhibits α-Synuclein Aggregation
|
Liang, Zhaohui
|
|
|
|
2 |
p. 180-190.e6
|
artikel
|
| 22 |
A Toxic RNA Catalyzes the Cellular Synthesis of Its Own Inhibitor, Shunting It to Endogenous Decay Pathways
|
Benhamou, Raphael I.
|
|
|
|
2 |
p. 223-231.e4
|
artikel
|
| 23 |
Bispecific antibody shuttles targeting CD98hc mediate efficient and long-lived brain delivery of IgGs
|
Pornnoppadol, Ghasidit
|
|
|
|
2 |
p. 361-372.e8
|
artikel
|
| 24 |
Blocking the Enablers: Selective Inhibition of CDK9 Reins in an Unchecked Master Regulator
|
Ansari, Aseem Z.
|
|
|
|
2 |
p. 113-115
|
artikel
|
| 25 |
Carbon Sources Tune Antibiotic Susceptibility in Pseudomonas aeruginosa via Tricarboxylic Acid Cycle Control
|
Meylan, Sylvain
|
|
2017
|
|
2 |
p. 195-206
|
artikel
|
| 26 |
CBP/p300 Bromodomain Mediates Amyloid Formation
|
Liao, Daiqing
|
|
2017
|
|
2 |
p. 128-129
|
artikel
|
| 27 |
Cell-Line Selectivity Improves the Predictive Power of Pharmacogenomic Analyses and Helps Identify NADPH as Biomarker for Ferroptosis Sensitivity
|
Shimada, Kenichi
|
|
2016
|
|
2 |
p. 225-235
|
artikel
|
| 28 |
Cellular reprogramming by protein degradation: The next frontier in cancer immunotherapy
|
Ehinger, Erik
|
|
|
|
2 |
p. 189-192
|
artikel
|
| 29 |
Chemically Induced Cell Wall Stapling in Bacteria
|
Rivera, Sylvia L.
|
|
|
|
2 |
p. 213-220.e4
|
artikel
|
| 30 |
Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells
|
Méndez-Mancilla, Alejandro
|
|
|
|
2 |
p. 321-327.e4
|
artikel
|
| 31 |
Chemistry Helps to Bump Off-Target Edits Away
|
Stafforst, Thorsten
|
|
2019
|
|
2 |
p. 151-152
|
artikel
|
| 32 |
Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention
|
Summers, Robert L.
|
|
|
|
2 |
p. 191-201.e8
|
artikel
|
| 33 |
Cold Stress Makes Escherichia coli Susceptible to Glycopeptide Antibiotics by Altering Outer Membrane Integrity
|
Stokes, Jonathan M.
|
|
2016
|
|
2 |
p. 267-277
|
artikel
|
| 34 |
Combinatorial Lanthipeptides from a Ruminant Bacterium
|
Donadio, Stefano
|
|
2016
|
|
2 |
p. 204-205
|
artikel
|
| 35 |
Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery
|
Murithi, James M.
|
|
|
|
2 |
p. 158-171.e3
|
artikel
|
| 36 |
Computing Substrate Selectivity in a Peptide Transporter
|
Colas, Claire
|
|
2016
|
|
2 |
p. 211-213
|
artikel
|
| 37 |
Conserved Lipid and Small-Molecule Modulation of COQ8 Reveals Regulation of the Ancient Kinase-like UbiB Family
|
Reidenbach, Andrew G.
|
|
2018
|
|
2 |
p. 154-165.e11
|
artikel
|
| 38 |
Convergent impact of vaccination and antibiotic pressures on pneumococcal populations
|
Johnson, Cydney N.
|
|
|
|
2 |
p. 195-206
|
artikel
|
| 39 |
c9orf72 Disease-Related Foci Are Each Composed of One Mutant Expanded Repeat RNA
|
Liu, Jing
|
|
2017
|
|
2 |
p. 141-148
|
artikel
|
| 40 |
Cross-Chemistry Leads to Product Diversity from Atromentin Synthetases in Aspergilli from Section Nigri
|
Geib, Elena
|
|
2019
|
|
2 |
p. 223-234.e6
|
artikel
|
| 41 |
Cytidine acetylation yields a hypoinflammatory synthetic messenger RNA
|
Nance, Kellie D.
|
|
|
|
2 |
p. 312-320.e7
|
artikel
|
| 42 |
“Death is my Heir”—Ferroptosis Connects Cancer Pharmacogenomics and Ischemia-Reperfusion Injury
|
Tonnus, Wulf
|
|
2016
|
|
2 |
p. 202-203
|
artikel
|
| 43 |
Development of an intracellular quantitative assay to measure compound binding kinetics
|
Lay, Charles S.
|
|
|
|
2 |
p. 287-299.e8
|
artikel
|
| 44 |
Differential network analysis of ROS1 inhibitors reveals lorlatinib polypharmacology through co-targeting PYK2
|
Liao, Yi
|
|
|
|
2 |
p. 284-297.e10
|
artikel
|
| 45 |
Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum
|
Esquejo, Ryan M.
|
|
|
|
2 |
p. 169-179.e7
|
artikel
|
| 46 |
Discovering Targets of Non-enzymatic Acylation by Thioester Reactivity Profiling
|
Kulkarni, Rhushikesh A.
|
|
2017
|
|
2 |
p. 231-242
|
artikel
|
| 47 |
Discovery of a First-In-Class Covalent Allosteric Inhibitor of SUMO E1 Activating Enzyme
|
Magin, Robert S.
|
|
2019
|
|
2 |
p. 153-155
|
artikel
|
| 48 |
Disorazoles Block Group A Streptococcal Invasion into Epithelial Cells Via Interference with the Host Factor Ezrin
|
Rox, Katharina
|
|
2017
|
|
2 |
p. 159-170
|
artikel
|
| 49 |
DogCatcher allows loop-friendly protein-protein ligation
|
Keeble, Anthony H.
|
|
|
|
2 |
p. 339-350.e10
|
artikel
|
| 50 |
Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions
|
Tang, Jing
|
|
2018
|
|
2 |
p. 224-229.e2
|
artikel
|
| 51 |
Engineered protein-small molecule conjugates empower selective enzyme inhibition
|
Lewis, Andrew K.
|
|
|
|
2 |
p. 328-338.e4
|
artikel
|
| 52 |
Engineering DNA-Templated Nonribosomal Peptide Synthesis
|
Huang, Hsin-Mei
|
|
|
|
2 |
p. 221-227.e7
|
artikel
|
| 53 |
Ferroptosis inhibition by oleic acid mitigates iron-overload-induced injury
|
Mann, Josiane
|
|
|
|
2 |
p. 249-264.e7
|
artikel
|
| 54 |
From Discovery to Bedside: Targeting the Ubiquitin System
|
Wertz, Ingrid E.
|
|
2019
|
|
2 |
p. 156-177
|
artikel
|
| 55 |
From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9
|
Petrilli, Whitney L.
|
|
|
|
2 |
p. 243
|
artikel
|
| 56 |
GDC-0879, a BRAFV600E Inhibitor, Protects Kidney Podocytes from Death
|
Sieber, Jonas
|
|
2018
|
|
2 |
p. 175-184.e4
|
artikel
|
| 57 |
Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples
|
Soule, Erin E.
|
|
|
|
2 |
p. 215-225.e5
|
artikel
|
| 58 |
Genetic retargeting of E3 ligases to enhance CAR T cell therapy
|
Lane, Isabel C.
|
|
|
|
2 |
p. 338-348.e5
|
artikel
|
| 59 |
Glycan Alteration Imparts Cellular Resistance to a Membrane-Lytic Anticancer Peptide
|
Ishikawa, Ken
|
|
2017
|
|
2 |
p. 149-158
|
artikel
|
| 60 |
14-Helical β-Peptides Elicit Toxicity against C. albicans by Forming Pores in the Cell Membrane and Subsequently Disrupting Intracellular Organelles
|
Lee, Myung-Ryul
|
|
2019
|
|
2 |
p. 289-299.e4
|
artikel
|
| 61 |
Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML
|
Brand, Matthias
|
|
2019
|
|
2 |
p. 300-306.e9
|
artikel
|
| 62 |
How Cancer Cells Become Resistant to Cationic Lytic Peptides: It’s the Sugar!
|
Pierce, Joshua G.
|
|
2017
|
|
2 |
p. 121-122
|
artikel
|
| 63 |
HSP90 Inhibition Enhances Cancer Immunotherapy by Modulating the Surface Expression of Multiple Immune Checkpoint Proteins
|
Zavareh, Reza Beheshti
|
|
|
|
2 |
p. 158-168.e5
|
artikel
|
| 64 |
Identification of a PCSK9-LDLR disruptor peptide with in vivo function
|
Brousseau, Margaret E.
|
|
|
|
2 |
p. 249-258.e5
|
artikel
|
| 65 |
Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA
|
Nagasawa, Ikuko
|
|
|
|
2 |
p. 186-196.e4
|
artikel
|
| 66 |
Identification of Chemotype Agonists for Human Resolvin D1 Receptor DRV1 with Pro-Resolving Functions
|
Chiang, Nan
|
|
2019
|
|
2 |
p. 244-254.e4
|
artikel
|
| 67 |
Increased energy demand from anabolic-catabolic processes drives β-lactam antibiotic lethality
|
Lobritz, Michael A.
|
|
|
|
2 |
p. 276-286.e4
|
artikel
|
| 68 |
Inhibition of Nonfunctional Ras
|
Nussinov, Ruth
|
|
|
|
2 |
p. 121-133
|
artikel
|
| 69 |
Inhibition of the Proteasome β2 Site Sensitizes Triple-Negative Breast Cancer Cells to β5 Inhibitors and Suppresses Nrf1 Activation
|
Weyburne, Emily S.
|
|
2017
|
|
2 |
p. 218-230
|
artikel
|
| 70 |
Insights into an Ancient Atypical Kinase Essential for Biosynthesis of Coenzyme Q
|
Clarke, Catherine F.
|
|
2018
|
|
2 |
p. 123-125
|
artikel
|
| 71 |
Interrogating direct NLRP3 engagement and functional inflammasome inhibition using cellular assays
|
Teske, Kelly A.
|
|
|
|
2 |
p. 349-360.e6
|
artikel
|
| 72 |
In This Issue
|
|
|
2016
|
|
2 |
p. vii-viii
|
artikel
|
| 73 |
Investigation of osteoclast cathepsin K activity in osteoclastogenesis and bone loss using a set of chemical reagents
|
Janiszewski, Tomasz
|
|
|
|
2 |
p. 159-174.e8
|
artikel
|
| 74 |
It’s about Time: Insights into the Modes of Action of Antimalarials
|
Toro-Moreno, Maria
|
|
|
|
2 |
p. 139-141
|
artikel
|
| 75 |
K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap
|
van Tilburg, Gabriëlle B.A.
|
|
|
|
2 |
p. 191-201.e8
|
artikel
|
| 76 |
Ligand-directed bias of G protein signaling at the dopamine D2 receptor
|
Von Moo, Ee
|
|
|
|
2 |
p. 226-238.e4
|
artikel
|
| 77 |
Making bubbles: Targeting VPS41 induces vacuolization and methuosis
|
Dekker, Nienke Julia
|
|
|
|
2 |
p. 127-129
|
artikel
|
| 78 |
Making HSP90 Inhibitors Great Again? Unite for Better Cancer Immunotherapy
|
Graner, Michael W.
|
|
|
|
2 |
p. 118-120
|
artikel
|
| 79 |
Making the cut with protease engineering
|
Dyer, Rebekah P.
|
|
|
|
2 |
p. 177-190
|
artikel
|
| 80 |
Mapping Proteome-wide Targets of Glyphosate in Mice
|
Ford, Breanna
|
|
2017
|
|
2 |
p. 133-140
|
artikel
|
| 81 |
Mechanism of Activation of AMPK by Cordycepin
|
Hawley, Simon A.
|
|
|
|
2 |
p. 214-222.e4
|
artikel
|
| 82 |
Meet the authors: Cydney N. Johnson, Shyra Wilde, Elaine Tuomanen, and Jason W. Rosch
|
Johnson, Cydney N.
|
|
|
|
2 |
p. 185-186
|
artikel
|
| 83 |
Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism
|
Abt, Evan R.
|
|
|
|
2 |
p. 197-205.e6
|
artikel
|
| 84 |
Methotrexate-based PROTACs as DHFR-specific chemical probes
|
Rana, Sandeep
|
|
|
|
2 |
p. 221-233.e14
|
artikel
|
| 85 |
Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors
|
Richters, André
|
|
|
|
2 |
p. 134-147.e14
|
artikel
|
| 86 |
Monstrous Mycobacterial Lipids
|
Seeliger, Jessica
|
|
2016
|
|
2 |
p. 207-209
|
artikel
|
| 87 |
Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis
|
Li, Dianrong
|
|
2016
|
|
2 |
p. 257-266
|
artikel
|
| 88 |
N6-methyladenosine modification in 18S rRNA promotes tumorigenesis and chemoresistance via HSF4b/HSP90B1/mutant p53 axis
|
Chen, Binbin
|
|
|
|
2 |
p. 144-158.e10
|
artikel
|
| 89 |
No acetyl-CoA keeps Plasmodium at bay
|
Jeffers, Victoria
|
|
|
|
2 |
p. 174-176
|
artikel
|
| 90 |
Noncanonical Streptococcus sanguinis ComCDE circuitry integrates environmental cues in transformation outcome decision
|
Guo, Mingzhe
|
|
|
|
2 |
p. 298-311.e6
|
artikel
|
| 91 |
Non-enzymatic Lysine Lactoylation of Glycolytic Enzymes
|
Gaffney, Dominique O.
|
|
|
|
2 |
p. 206-213.e6
|
artikel
|
| 92 |
NosP-Regulated Nosiheptide Production Responds to Both Peptidyl and Small-Molecule Ligands Derived from the Precursor Peptide
|
Li, Jingjing
|
|
2018
|
|
2 |
p. 143-153.e4
|
artikel
|
| 93 |
Novel FRET-Based Src Biosensor Reveals Mechanisms of Src Activation and Its Dynamics in Focal Adhesions
|
Koudelková, Lenka
|
|
2019
|
|
2 |
p. 255-268.e4
|
artikel
|
| 94 |
Objective, Quantitative, Data-Driven Assessment of Chemical Probes
|
Antolin, Albert A.
|
|
2018
|
|
2 |
p. 194-205.e5
|
artikel
|
| 95 |
Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors
|
Gao, Yang
|
|
2018
|
|
2 |
p. 135-142.e5
|
artikel
|
| 96 |
PhoDAGs Enable Optical Control of Diacylglycerol-Sensitive Transient Receptor Potential Channels
|
Leinders-Zufall, Trese
|
|
2018
|
|
2 |
p. 215-223.e3
|
artikel
|
| 97 |
Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE
|
Seneviratne, Uthpala
|
|
|
|
2 |
p. 148-157.e7
|
artikel
|
| 98 |
PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer
|
Torres-Ayuso, Pedro
|
|
|
|
2 |
p. 326-337.e11
|
artikel
|
| 99 |
Piperlongumine conjugates induce targeted protein degradation
|
Pei, Jing
|
|
|
|
2 |
p. 203-213.e17
|
artikel
|
| 100 |
Profiling of drug resistance in Src kinase at scale uncovers a regulatory network coupling autoinhibition and catalytic domain dynamics
|
Chakraborty, Sujata
|
|
|
|
2 |
p. 207-220.e11
|
artikel
|
| 101 |
Profiling of MicroRNA Targets Using Activity-Based Protein Profiling: Linking Enzyme Activity to MicroRNA-185 Function
|
Filip, Roxana
|
|
|
|
2 |
p. 202-212.e6
|
artikel
|
| 102 |
Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement
|
Vasta, James D.
|
|
2018
|
|
2 |
p. 206-214.e11
|
artikel
|
| 103 |
Regulation of Virulence in Staphylococcus aureus: Molecular Mechanisms and Remaining Puzzles
|
Wang, Boyuan
|
|
2016
|
|
2 |
p. 214-224
|
artikel
|
| 104 |
Science that Inspires
|
|
|
|
|
2 |
p. 135-136
|
artikel
|
| 105 |
Screening Drugs for Kidney Disease: Targeting the Podocyte
|
Bryer, Joshua S.
|
|
2018
|
|
2 |
p. 126-127
|
artikel
|
| 106 |
Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production
|
Nguyen, Thu P.
|
|
|
|
2 |
p. 214-229.e18
|
artikel
|
| 107 |
Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest
|
Rodencal, Jason
|
|
|
|
2 |
p. 234-248.e13
|
artikel
|
| 108 |
Shining a Light on Phenotypic Drug Discovery
|
Hsu, Ku-Lung
|
|
|
|
2 |
p. 115-117
|
artikel
|
| 109 |
Site-Specific Installation of Succinyl Lysine Analog into Histones Reveals the Effect of H2BK34 Succinylation on Nucleosome Dynamics
|
Jing, Yihang
|
|
2018
|
|
2 |
p. 166-174.e7
|
artikel
|
| 110 |
Specific Inhibition of the Bifunctional Farnesyl/Geranylgeranyl Diphosphate Synthase in Malaria Parasites via a New Small-Molecule Binding Site
|
Gisselberg, Jolyn E.
|
|
2018
|
|
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