| nr |
titel |
auteur |
tijdschrift |
jaar |
jaarg. |
afl. |
pagina('s) |
type |
| 1 |
A Catalytic Trisulfide in Human Sulfide Quinone Oxidoreductase Catalyzes Coenzyme A Persulfide Synthesis and Inhibits Butyrate Oxidation
|
Landry, Aaron P.
|
|
|
|
11 |
p. 1515-1525.e4
|
artikel
|
| 2 |
Acid Derivatives of Pyrazolo[1,5-a]pyrimidine as Aldose Reductase Differential Inhibitors
|
Balestri, Francesco
|
|
2018
|
|
11 |
p. 1414-1418.e3
|
artikel
|
| 3 |
Acute pharmacological degradation of ERK5 does not inhibit cellular immune response or proliferation
|
You, Inchul
|
|
|
|
11 |
p. 1630-1638.e7
|
artikel
|
| 4 |
Addicted to proteostasis: How KRAS-driven cancers acquire resistance to clinical KRAS inhibitors
|
Klein, Austin T.
|
|
|
|
11 |
p. 1334-1336
|
artikel
|
| 5 |
Addressing the Enzyme-independent tumor-promoting function of NAMPT via PROTAC-mediated degradation
|
Zhu, Xiaotong
|
|
|
|
11 |
p. 1616-1629.e12
|
artikel
|
| 6 |
A fine-tuned azobenzene for enhanced photopharmacology in vivo
|
Gutzeit, Vanessa A.
|
|
|
|
11 |
p. 1648-1663.e16
|
artikel
|
| 7 |
A high-performance genetically encoded fluorescent biosensor for imaging physiological peroxynitrite
|
Chen, Zhijie
|
|
|
|
11 |
p. 1542-1553.e5
|
artikel
|
| 8 |
ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species
|
Zhou, Linna
|
|
|
|
11 |
p. 1452
|
artikel
|
| 9 |
A “light” touch on PI3K to interrogate cancer drug resistance
|
Wang, Tianlu
|
|
|
|
11 |
p. 1573-1575
|
artikel
|
| 10 |
Allosteric Inhibition of a Semaphorin 4D Receptor Plexin B1 by a High-Affinity Macrocyclic Peptide
|
Matsunaga, Yukiko
|
|
|
|
11 |
p. 1341-1350
|
artikel
|
| 11 |
Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors
|
Chu, Jennifer
|
|
|
|
11 |
p. 1586-1593.e3
|
artikel
|
| 12 |
Anti-tumor effect of PD-L1-targeting antagonistic aptamer-ASO delivery system with dual inhibitory function in immunotherapy
|
Luo, Fatao
|
|
|
|
11 |
p. 1390-1401.e6
|
artikel
|
| 13 |
APD-Containing Cyclolipodepsipeptides Target Mitochondrial Function in Hypoxic Cancer Cells
|
Jacobsen, Kristian Mark
|
|
2018
|
|
11 |
p. 1337-1349.e12
|
artikel
|
| 14 |
A PROTAC targets splicing factor 3B1
|
Gama-Brambila, Rodrigo A.
|
|
|
|
11 |
p. 1616-1627.e8
|
artikel
|
| 15 |
Arabinose- and xylose-modified analogs of 2′,3′-cGAMP act as STING agonists
|
Xie, Wei
|
|
|
|
11 |
p. 1366-1376.e7
|
artikel
|
| 16 |
Arabinosylation Modulates the Growth-Regulating Activity of the Peptide Hormone CLE40a from Soybean
|
Corcilius, Leo
|
|
2017
|
|
11 |
p. 1347-1355.e7
|
artikel
|
| 17 |
A Semi-synthetic Oligosaccharide Conjugate Vaccine Candidate Confers Protection against Streptococcus pneumoniae Serotype 3 Infection
|
Parameswarappa, Sharavathi Guddehalli
|
|
|
|
11 |
p. 1407-1416
|
artikel
|
| 18 |
A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation
|
Petersen, Donna N.
|
|
|
|
11 |
p. 1362-1371
|
artikel
|
| 19 |
A Small-Molecule Inhibitor of Iron-Sulfur Cluster Assembly Uncovers a Link between Virulence Regulation and Metabolism in Staphylococcus aureus
|
Choby, Jacob E.
|
|
|
|
11 |
p. 1351-1361
|
artikel
|
| 20 |
A synthetic RNA-based biosensor for fructose-1,6-bisphosphate that reports glycolytic flux
|
Ortega, Alvaro Darío
|
|
|
|
11 |
p. 1554-1568.e8
|
artikel
|
| 21 |
A Targeted Protein Degradation Cell-Based Screening for Nanobodies Selective toward the Cellular RHOB GTP-Bound Conformation
|
Bery, Nicolas
|
|
|
|
11 |
p. 1544-1558.e6
|
artikel
|
| 22 |
Beyond DPPH: Use of Fluorescence-Enabled Inhibited Autoxidation to Predict Oxidative Cell Death Rescue
|
Shah, Ron
|
|
|
|
11 |
p. 1594-1607.e7
|
artikel
|
| 23 |
Bond with Me If You Can! Natural Product, Covalent Ligand, and Reactivity-Based Probe Compete for Cysteine in PP2A Complex
|
Johnson, Douglas S.
|
|
2017
|
|
11 |
p. 1317-1318
|
artikel
|
| 24 |
Boron-Based Inhibitors of the NLRP3 Inflammasome
|
Baldwin, Alex G.
|
|
2017
|
|
11 |
p. 1321-1335.e5
|
artikel
|
| 25 |
Cancer Cell Drug Response Transcriptomes in 3D
|
Wennerberg, Krister
|
|
|
|
11 |
p. 1323-1324
|
artikel
|
| 26 |
Chemogenomic Analysis of the Druggable Kinome and Its Application to Repositioning and Lead Identification Studies
|
Ravikumar, Balaguru
|
|
|
|
11 |
p. 1608-1622.e6
|
artikel
|
| 27 |
Chemoproteomic profiling to identify activity changes and functional inhibitors of DNA-binding proteins
|
Ruprecht, Benjamin
|
|
|
|
11 |
p. 1639-1648.e4
|
artikel
|
| 28 |
Combining Mutational Signatures, Clonal Fitness, and Drug Affinity to Define Drug-Specific Resistance Mutations in Cancer
|
Kaserer, Teresa
|
|
2018
|
|
11 |
p. 1359-1371.e2
|
artikel
|
| 29 |
Come for the atmosphere, stay for the interactions: Deciphering small molecule partitioning into biomolecular condensates
|
Sepehri, Bakhtyar
|
|
|
|
11 |
p. 1337-1339
|
artikel
|
| 30 |
Controlled Inhibition of Apoptosis by Photoactivatable Caspase Inhibitors
|
Chakrabarty, Suravi
|
|
|
|
11 |
p. 1434-1440.e10
|
artikel
|
| 31 |
Covalent Ligand Discovery against Druggable Hotspots Targeted by Anti-cancer Natural Products
|
Grossman, Elizabeth A.
|
|
2017
|
|
11 |
p. 1368-1376.e4
|
artikel
|
| 32 |
Cryo-EM for Small Molecules Discovery, Design, Understanding, and Application
|
Scapin, Giovanna
|
|
2018
|
|
11 |
p. 1318-1325
|
artikel
|
| 33 |
CryoEM structures of adhesion in GPCR CD97: Filling in some of the gaps
|
Krumm, Brian E.
|
|
|
|
11 |
p. 1327-1329
|
artikel
|
| 34 |
Custom Glycosylation of Cells and Proteins Using Cyclic Carbamate-Derivatized Oligosaccharides
|
Whitehead, Marek W.J.
|
|
2017
|
|
11 |
p. 1336-1346.e3
|
artikel
|
| 35 |
Dawn of a New Era of Targeted Antioxidant Therapies
|
Stockwell, Brent R.
|
|
|
|
11 |
p. 1483-1485
|
artikel
|
| 36 |
Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria
|
Gandhi, Shiv
|
|
|
|
11 |
p. 1410-1424.e6
|
artikel
|
| 37 |
Design on a Rational Basis of High-Affinity Peptides Inhibiting the Histone Chaperone ASF1
|
Bakail, May
|
|
|
|
11 |
p. 1573-1585.e10
|
artikel
|
| 38 |
Detecting and Imaging O-GlcNAc Sites Using Glycosyltransferases: A Systematic Approach to Study O-GlcNAc
|
Wu, Zhengliang L.
|
|
2018
|
|
11 |
p. 1428-1435.e3
|
artikel
|
| 39 |
Dioctatin Activates ClpP to Degrade Mitochondrial Components and Inhibits Aflatoxin Production
|
Furukawa, Tomohiro
|
|
|
|
11 |
p. 1396-1409.e10
|
artikel
|
| 40 |
Discovery and Development of TMPRSS6 Inhibitors Modulating Hepcidin Levels in Human Hepatocytes
|
Béliveau, François
|
|
|
|
11 |
p. 1559-1572.e9
|
artikel
|
| 41 |
Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function
|
Robbins, Nicole
|
|
|
|
11 |
p. 1383-1394
|
artikel
|
| 42 |
Discovery of Ibomycin, a Potent Antifungal Weapon
|
Alspaugh, J. Andrew
|
|
|
|
11 |
p. 1321-1322
|
artikel
|
| 43 |
Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms
|
Maculins, Timurs
|
|
|
|
11 |
p. 1441-1451.e7
|
artikel
|
| 44 |
Divergent JNK Phosphorylation of HDAC3 in Triple-Negative Breast Cancer Cells Determines HDAC Inhibitor Binding and Selectivity
|
Hanigan, Thomas W.
|
|
2017
|
|
11 |
p. 1356-1367.e8
|
artikel
|
| 45 |
DNA template strand segregation in developing zebrafish
|
Glasauer, Stella M.K.
|
|
|
|
11 |
p. 1638-1647.e4
|
artikel
|
| 46 |
Dual Targeting of v-ATPase and mTORC1 Signaling Disarms Multidrug-Resistant Cancers
|
Turocy, Tayah
|
|
|
|
11 |
p. 1329-1331
|
artikel
|
| 47 |
Enabling inclusion and looking ahead
|
Dey, Mishtu
|
|
|
|
11 |
p. 1323
|
artikel
|
| 48 |
Enzyme Allostery: Now Controllable by Light
|
Courtney, Taylor M.
|
|
|
|
11 |
p. 1481-1483
|
artikel
|
| 49 |
Epidithiodiketopiperazines Inhibit Protein Degradation by Targeting Proteasome Deubiquitinase Rpn11
|
Li, Jing
|
|
2018
|
|
11 |
p. 1350-1358.e9
|
artikel
|
| 50 |
Eukaryotic Ribosome as a Target for Cardiovascular Disease
|
Pellegrino, Simone
|
|
|
|
11 |
p. 1319-1321
|
artikel
|
| 51 |
Exposing the Unique Connection between Metabolism and Virulence in Staphylococcus aureus
|
Weiss, Andy
|
|
|
|
11 |
p. 1317-1319
|
artikel
|
| 52 |
Family-wide Annotation of Enzymatic Pathways by Parallel In Vivo Metabolomics
|
Kim, Joon T.
|
|
|
|
11 |
p. 1623-1629.e3
|
artikel
|
| 53 |
Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein
|
Armenta, David A.
|
|
|
|
11 |
p. 1588-1600.e7
|
artikel
|
| 54 |
Fine-tuning chemical genetics to identify physiologic drug targets
|
Vostal, Lauren E.
|
|
|
|
11 |
p. 1331-1333
|
artikel
|
| 55 |
Formation of the Alarmones Diadenosine Triphosphate and Tetraphosphate by Ubiquitin- and Ubiquitin-like-Activating Enzymes
|
Götz, Kathrin H.
|
|
|
|
11 |
p. 1535-1543.e5
|
artikel
|
| 56 |
From Glioblastoma to Hepatitis C: It’s a Metabolism Thing
|
Kostic, Milka
|
|
|
|
11 |
p. 1315-1316
|
artikel
|
| 57 |
Generating Functional Recombinant NRPS Enzymes in the Laboratory Setting via Peptidyl Carrier Protein Engineering
|
Owen, Jeremy G.
|
|
|
|
11 |
p. 1395-1406
|
artikel
|
| 58 |
Genetically incorporated crosslinkers identify regulators of membrane protein PD-L1 in mammalian cells
|
Chai, Fangni
|
|
|
|
11 |
p. 1488-1497.e5
|
artikel
|
| 59 |
Glucose Metabolism and Oxygen Availability Govern Reactivation of the Latent Human Retrovirus HTLV-1
|
Kulkarni, Anurag
|
|
2017
|
|
11 |
p. 1377-1387.e3
|
artikel
|
| 60 |
HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation
|
Xiao, Yufeng
|
|
|
|
11 |
p. 1421-1435.e12
|
artikel
|
| 61 |
Hit Triage and Validation in Phenotypic Screening: Considerations and Strategies
|
Vincent, Fabien
|
|
|
|
11 |
p. 1332-1346
|
artikel
|
| 62 |
How to kill an ERKsome target: PROTACs deliver the deathblow
|
Potts, Malia B.
|
|
|
|
11 |
p. 1569-1571
|
artikel
|
| 63 |
Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules
|
Nguyen, Thu P.
|
|
|
|
11 |
p. 1453-1467.e8
|
artikel
|
| 64 |
Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site
|
Fang, Zhenhao
|
|
2018
|
|
11 |
p. 1327-1336.e4
|
artikel
|
| 65 |
In This Issue
|
|
|
|
|
11 |
p. vii-ix
|
artikel
|
| 66 |
In vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin
|
Gonciarz, Ryan L.
|
|
|
|
11 |
p. 1468-1477.e6
|
artikel
|
| 67 |
Just a Spoonful of Sugar, HTLV-1 Style
|
Taylor, Naomi
|
|
2017
|
|
11 |
p. 1319-1320
|
artikel
|
| 68 |
Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids
|
Senkowski, Wojciech
|
|
|
|
11 |
p. 1428-1438
|
artikel
|
| 69 |
Light Regulation of Enzyme Allostery through Photo-responsive Unnatural Amino Acids
|
Kneuttinger, Andrea C.
|
|
|
|
11 |
p. 1501-1514.e9
|
artikel
|
| 70 |
Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate
|
Graboski, Amanda L.
|
|
|
|
11 |
p. 1402-1413.e7
|
artikel
|
| 71 |
Mechanistic insights into cancer drug resistance through optogenetic PI3K signaling hyperactivation
|
Ueda, Yoshibumi
|
|
|
|
11 |
p. 1576-1587.e5
|
artikel
|
| 72 |
Mechanistic Studies of the Multiple Myeloma and Melanoma Cell-Selective Toxicity of the Rpn13-Binding Peptoid KDT-11
|
Dickson, Paige
|
|
|
|
11 |
p. 1383-1395.e5
|
artikel
|
| 73 |
Multicolor Electron Microscopy for Simultaneous Visualization of Multiple Molecular Species
|
Adams, Stephen R.
|
|
|
|
11 |
p. 1417-1427
|
artikel
|
| 74 |
Multimodal, broadly neutralizing antibodies against SARS-CoV-2 identified by high-throughput native pairing of BCRs from bulk B cells
|
Keitany, Gladys J.
|
|
|
|
11 |
p. 1377-1389.e8
|
artikel
|
| 75 |
Multiplexed bioluminescence imaging with a substrate unmixing platform
|
Brennan, Caroline K.
|
|
|
|
11 |
p. 1649-1660.e4
|
artikel
|
| 76 |
Multiplexed Thiol Reactivity Profiling for Target Discovery of Electrophilic Natural Products
|
Tian, Caiping
|
|
2017
|
|
11 |
p. 1416-1427.e5
|
artikel
|
| 77 |
Naturally occurring three-way junctions can be repurposed as genetically encoded RNA-based sensors
|
Moon, Jared D.
|
|
|
|
11 |
p. 1569-1580.e4
|
artikel
|
| 78 |
New advisory board members speak on challenges and opportunities in chemical biology
|
Li, Xiang David
|
|
|
|
11 |
p. 1324-1326
|
artikel
|
| 79 |
NIH Support for FDA-Approved Medicines
|
Griesenauer, Rebekah H.
|
|
2017
|
|
11 |
p. 1315-1316
|
artikel
|
| 80 |
Oxygen Starvation Unmasks a Killer
|
Svec, Riley L.
|
|
2018
|
|
11 |
p. 1313-1314
|
artikel
|
| 81 |
PCNA degradation exhibits superior pharmacological effects over stoichiometric inhibition
|
Basu, Ananya A.
|
|
|
|
11 |
p. 1571-1573
|
artikel
|
| 82 |
Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer
|
Wang, Yuezhou
|
|
|
|
11 |
p. 1359-1370.e8
|
artikel
|
| 83 |
Photocontrol of Endogenous Glycine Receptors In Vivo
|
Gomila, Alexandre M.J.
|
|
|
|
11 |
p. 1425-1433.e7
|
artikel
|
| 84 |
Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190
|
Dickson, Paige
|
|
|
|
11 |
p. 1371-1382.e6
|
artikel
|
| 85 |
Potent α-Synuclein Aggregation Inhibitors, Identified by High-Throughput Screening, Mainly Target the Monomeric State
|
Kurnik, Martin
|
|
2018
|
|
11 |
p. 1389-1402.e9
|
artikel
|
| 86 |
Probing Exchange Units for Combining Iterative and Linear Fungal Nonribosomal Peptide Synthetases
|
Steiniger, Charlotte
|
|
|
|
11 |
p. 1526-1534.e2
|
artikel
|
| 87 |
Profiling the Metabolism of Human Cells by Deep 13C Labeling
|
Grankvist, Nina
|
|
2018
|
|
11 |
p. 1419-1427.e4
|
artikel
|
| 88 |
Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors
|
Niessen, Sherry
|
|
2017
|
|
11 |
p. 1388-1400.e7
|
artikel
|
| 89 |
Protomer selectivity of type II RAF inhibitors within the RAS/RAF complex
|
Vasta, James D.
|
|
|
|
11 |
p. 1354-1365.e6
|
artikel
|
| 90 |
Raf protomers: Drug binding preferences in living cells
|
Dalby, Kevin N.
|
|
|
|
11 |
p. 1329-1331
|
artikel
|
| 91 |
Reactive Persulfides from Salmonella Typhimurium Downregulate Autophagy-Mediated Innate Immunity in Macrophages by Inhibiting Electrophilic Signaling
|
Khan, Shahzada
|
|
2018
|
|
11 |
p. 1403-1413.e4
|
artikel
|
| 92 |
Re-awakening Innate Immune Signaling in Cancer: The Development of Highly Potent ENPP1 Inhibitors
|
Cogan, Derek
|
|
|
|
11 |
p. 1327-1328
|
artikel
|
| 93 |
Recent Advances in Selective and Irreversible Covalent Ligand Development and Validation
|
Zhang, Tinghu
|
|
|
|
11 |
p. 1486-1500
|
artikel
|
| 94 |
RNA-DNA Triplex Formation by Long Noncoding RNAs
|
Li, Yue
|
|
|
|
11 |
p. 1325-1333
|
artikel
|
| 95 |
Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket
|
Forster, Michael
|
|
|
|
11 |
p. 1335-1340
|
artikel
|
| 96 |
Selenocysteine-Specific Mass Spectrometry Reveals Tissue-Distinct Selenoproteomes and Candidate Selenoproteins
|
Guo, Lin
|
|
2018
|
|
11 |
p. 1380-1388.e4
|
artikel
|
| 97 |
Self-Assembly of 3D DNA Crystals Containing a Torsionally Stressed Component
|
Hernandez, Carina
|
|
2017
|
|
11 |
p. 1401-1406.e2
|
artikel
|
| 98 |
Shipworm symbiosis ecology-guided discovery of an antibiotic that kills colistin-resistant Acinetobacter
|
Miller, Bailey W.
|
|
|
|
11 |
p. 1628-1637.e4
|
artikel
|
| 99 |
Specific inhibition of oncogenic RAS using cell-permeable RAS-binding domains
|
Nomura, Teiko Komori
|
|
|
|
11 |
p. 1581-1589.e6
|
artikel
|
| 100 |
Structural basis of CD97 activation and G-protein coupling
|
Wang, Na
|
|
|
|
11 |
p. 1343-1353.e5
|
artikel
|
| 101 |
Structure-Aided Development of Small-Molecule Inhibitors of ENPP1, the Extracellular Phosphodiesterase of the Immunotransmitter cGAMP
|
Carozza, Jacqueline A.
|
|
|
|
11 |
p. 1347-1358.e5
|
artikel
|
| 102 |
Structure of the Guanidine III Riboswitch
|
Huang, Lin
|
|
2017
|
|
11 |
p. 1407-1415.e2
|
artikel
|
| 103 |
Sweet sensation: Developing a single-cell fluorescent reporter of glycolytic heterogeneity
|
Karloff, Diane B.
|
|
|
|
11 |
p. 1539-1541
|
artikel
|
| 104 |
Target deconvolution with matrix-augmented pooling strategy reveals cell-specific drug-protein interactions
|
Ji, Hongchao
|
|
|
|
11 |
p. 1478-1487.e7
|
artikel
|
| 105 |
Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death
|
Chang, Shih Chieh
|
|
|
|
11 |
p. 1601-1615.e7
|
artikel
|
| 106 |
Targeted kinase degradation via the KLHDC2 ubiquitin E3 ligase
|
Kim, Younghoon
|
|
|
|
11 |
p. 1414-1420.e5
|
artikel
|
| 107 |
Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library
|
Emery, Amy
|
|
|
|
11 |
p. 1602-1615.e9
|
artikel
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| 108 |
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