| nr |
titel |
auteur |
tijdschrift |
jaar |
jaarg. |
afl. |
pagina('s) |
type |
| 1 |
ABC efflux transporters and drug toxicity
|
Schuetz, John
|
|
2019
|
34 |
1S |
p. S6
|
artikel
|
| 2 |
ABC xenobiotic transporters play important roles in systemic exposure and dermal distribution of tyrosine kinase inhibitor regorafenib and its active metabolites
|
Katov, Yukio
|
|
2019
|
34 |
1S |
p. S73
|
artikel
|
| 3 |
Academic and industry perspectives on pharmacogenomics: drug optimization
|
Shuldiner, Alan
|
|
2019
|
34 |
1S |
p. S6
|
artikel
|
| 4 |
Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR
|
Yoshinari, Kouichi
|
|
2019
|
34 |
1S |
p. S51
|
artikel
|
| 5 |
Activity-based proteomics – protein and ligand discovery on a global scale
|
Cravatt, Benjamin
|
|
2019
|
34 |
1S |
p. S14
|
artikel
|
| 6 |
A direct comparison of assay detection methods for the assessment of transporter-mediated drug interactions
|
Sayer, Rachel
|
|
2019
|
34 |
1S |
p. S77
|
artikel
|
| 7 |
Adverse effects of psychiatric drugs on bone: Does drug distribution to marrow play a role?
|
Houseknecht, Karen
|
|
2019
|
34 |
1S |
p. S31
|
artikel
|
| 8 |
A Facile chemical derivatization method to discern the identity of glucronide conjugates of carboxylic acid drugs under mild conditions
|
Wang, Kai
|
|
2019
|
34 |
1S |
p. S62
|
artikel
|
| 9 |
A human liver microphysiology system for drug discovery and development
|
Taylor, D. Lansing
|
|
2019
|
34 |
1S |
p. S9
|
artikel
|
| 10 |
Aldehyde oxidase activity in human vascular tissue and its potential contribution to extra-hepatic metabolism
|
Kozminski, Kirk
|
|
2019
|
34 |
1S |
p. S62-S63
|
artikel
|
| 11 |
Ameliorating effect of baicalin in cadmium induced kidney fibrosis
|
Siddarth, Manushi
|
|
2019
|
34 |
1S |
p. S18-S19
|
artikel
|
| 12 |
Amiloride as a probe substrate for investigation of organic cation transport system
|
Kaneko, Chisa
|
|
2019
|
34 |
1S |
p. S73
|
artikel
|
| 13 |
A mouse model for investigating human brain CYP2D6
|
Tolledo, Edgor Cole
|
|
2019
|
34 |
1S |
p. S15
|
artikel
|
| 14 |
An efficient high throughput 96-well plated human hepatocytes assay for drug uptake and uptake transporter inhibition
|
Li, Albert P.
|
|
2019
|
34 |
1S |
p. S48
|
artikel
|
| 15 |
A new CYP-silenced CELL-Based assay for direct measurement of the contribution of major cytochrome P450 enzymes to drug clearance/metabolism
|
Sharma, Ashwani
|
|
2019
|
34 |
1S |
p. S28
|
artikel
|
| 16 |
Animal models for drug transporters
|
Bow, Daniel
|
|
2019
|
34 |
1S |
p. S1
|
artikel
|
| 17 |
An integrated in vitro screen using sandwich-cultured human hepatocytes for prediction of cholestatic hepatotoxicity
|
Jackson, Jonathan
|
|
2019
|
34 |
1S |
p. S35
|
artikel
|
| 18 |
A non-linear mixed-effects model to describe the population pharmacokinetics of mycophenolic acid and the effects of co-variates in adult, de-novo kidney transplant patients on steroid-free anti-rejection regimens
|
Rong, Yan
|
|
2019
|
34 |
1S |
p. S65
|
artikel
|
| 19 |
A novel ‘bottom-up’ physiologically based pharmacokinetic (PBPK) model of itraconazole and its metabolites: the importance of enzyme kinetics and protein binding
|
Garcia, Luna Prieto
|
|
2019
|
34 |
1S |
p. S70-S71
|
artikel
|
| 20 |
A Novel strategy for CYP3A4 Induction screening in drug discovery: use of heparg cells and simplified relative induction score method
|
Aratsu, Yusuke
|
|
2019
|
34 |
1S |
p. S42
|
artikel
|
| 21 |
A Pharmacokinetic natural product-disease-drug interaction: a double-hit on hepatic transporters
|
Clarke, John
|
|
2019
|
34 |
1S |
p. S67-S68
|
artikel
|
| 22 |
A physiologically based pharmacokinetic model (PBPK) utilizing specific muscle tissue for intramuscular injection of therapeutic proteins
|
Chow, Timothy
|
|
2019
|
34 |
1S |
p. S19
|
artikel
|
| 23 |
Apparent noncompetitive inhibition of BSEP in primary human hepatocytes associated with severe drug-induced liver injury
|
He, Kan
|
|
2019
|
34 |
1S |
p. S72
|
artikel
|
| 24 |
Application of DMPK toolbox in predicting human pharmacokinetics for back-up RIP1 inhibitors: Learnings from GSK2982772 in clinic
|
Mahajan, Mukesh
|
|
2019
|
34 |
1S |
p. S66-S67
|
artikel
|
| 25 |
Application of non-standard approaches to investigations of human mass balance and metabolite characterisation
|
Shaw, Iain
|
|
2019
|
34 |
1S |
p. S38
|
artikel
|
| 26 |
Application of PBPK modeling to evaluate pharmacokinetic drug-drug interactions during the development of new antimalarial combination therapies
|
Abla, Nada
|
|
2019
|
34 |
1S |
p. S68-S69
|
artikel
|
| 27 |
Are CYP3A5 expresser subpopulations at an increased risk for acetaminophen toxicity?
|
Mizuno, Kunihiko
|
|
2019
|
34 |
1S |
p. S26
|
artikel
|
| 28 |
Assessment of interaction with nucleosidal transporters between enasidenib and azacytidine
|
Yerramilli, Usha
|
|
2019
|
34 |
1S |
p. S42
|
artikel
|
| 29 |
Association of glutathione S-transferase genes (GSTM1 AND GSTT1) with blood lead levels in occupationally lead-exposed workers
|
Himani,
|
|
2019
|
34 |
1S |
p. S78-S79
|
artikel
|
| 30 |
Association of high blood lead levels with FOK1, APA1 and BSM1 Vitamin D Receptor gene polymorphism in occupationally exposed battery workers
|
Himani,
|
|
2019
|
34 |
1S |
p. S28-S29
|
artikel
|
| 31 |
ATP-Binding cassette transporters and CYP450 Isoforms are possible sites of ribociclib drug interactions
|
Sorf, Ales
|
|
2019
|
34 |
1S |
p. S41
|
artikel
|
| 32 |
Author Index
|
|
|
2019
|
34 |
1S |
p. I-VI
|
artikel
|
| 33 |
AZ1 – A CYP3A4 inducer with a complex DDI prediction analysis
|
Grime, Ken
|
|
2019
|
34 |
1S |
p. S11
|
artikel
|
| 34 |
BBB-on-a-chip: A 3D In vitro model of the human blood-brain barrier
|
Lowman, John
|
|
2019
|
34 |
1S |
p. S54
|
artikel
|
| 35 |
Bioinformatics: Accumulating and implementing pharmacogenomics information
|
Whirl-Carrillo, Michelle
|
|
2019
|
34 |
1S |
p. S6
|
artikel
|
| 36 |
Biotransformation of ADCs. Pathways and enzymes
|
Zhang, Donglu
|
|
2019
|
34 |
1S |
p. S13
|
artikel
|
| 37 |
Biotransformation of Pyrrolizidine alkaloid N-Oxide to hepatotoxic Pyrrolizidine alkaloid
|
Lin, Ge
|
|
2019
|
34 |
1S |
p. S58-S59
|
artikel
|
| 38 |
Can transporter-expressing cells predict rosuvastatin uptake clearance in suspended or plated human hepatocytes?
|
Kumar, Vineet
|
|
2019
|
34 |
1S |
p. S22-S23
|
artikel
|
| 39 |
Case studies in quality levels for in vitro adme assays: Hepatocyte stability
|
Sierra, Teresa
|
|
2019
|
34 |
1S |
p. S50-S51
|
artikel
|
| 40 |
Cellular distribution of biologics: A comparison of microautoradiography techniques
|
Harris, Stephen
|
|
2019
|
34 |
1S |
p. S32
|
artikel
|
| 41 |
Characterising the immune response to carbamazepine: Understanding the development of idiosyncratic drug reactions
|
Jee, Alison
|
|
2019
|
34 |
1S |
p. S51-S52
|
artikel
|
| 42 |
Characterization and ADME properties of a novel auristatin payload-based ADC
|
Leal, Mauricio
|
|
2019
|
34 |
1S |
p. S9
|
artikel
|
| 43 |
Characterization of antihypertensive drugs as potent inhibitors of CYP2J2
|
Yamaori, Satoshi
|
|
2019
|
34 |
1S |
p. S46
|
artikel
|
| 44 |
Characterization of cisplatin toxicity in aproximate human proximal tubule cell monolayers
|
Brown, Colin
|
|
2019
|
34 |
1S |
p. S52-S53
|
artikel
|
| 45 |
Characterization of CYP2C Induction in Cryopreserved human hepatocytes and ITS Application in the prediction of the clinical consequences of the induction
|
Nagai, Mika
|
|
2019
|
34 |
1S |
p. S43
|
artikel
|
| 46 |
Characterization of GCDC transport by human hepatic uptake transporters for in vitro testing purposes
|
Toth, Beata
|
|
2019
|
34 |
1S |
p. S77
|
artikel
|
| 47 |
Characterization of human hepatocytes by quantitative dmet proteomics addresses lot-to-lot variability: relevance in In-vitro to In-vivo extrapolation of hepatic drug clearance
|
Prasad, Bhagwat
|
|
2019
|
34 |
1S |
p. S23-S24
|
artikel
|
| 48 |
Characterization of individual differences in CYP3A5 Activity using a CYP3A5-Selective marker reaction in vitro
|
Jackson, Klarissa
|
|
2019
|
34 |
1S |
p. S25-S26
|
artikel
|
| 49 |
Characterization of the CYP and UGT enzymes involved in reactive metabolite generation from bromfenac and bromfenac indolinone
|
Yadav, Aprajita
|
|
2019
|
34 |
1S |
p. S62
|
artikel
|
| 50 |
Chemical-induced toxicity is ameliorated by swimming exercise in caenorhabditis elegans
|
Hartman, Jessica
|
|
2019
|
34 |
1S |
p. S30
|
artikel
|
| 51 |
Circulating hormones and nuclear hormone receptor expression are associated with treatment-free survival in patients with chronic lymphocytic leukemia
|
Allain, Eric
|
|
2019
|
34 |
1S |
p. S29
|
artikel
|
| 52 |
Clinical validation and utility of coproporphyrins as endogenous probes to predict OATP1B-mediated drug-drug interactions
|
Shen, Hong
|
|
2019
|
34 |
1S |
p. S12
|
artikel
|
| 53 |
CO-Culture of primary hepatic stellate cells and hepatocytes in modeling of liver fibrosis in 2D and 3D Spheroids
|
Witek, Rafal
|
|
2019
|
34 |
1S |
p. S56
|
artikel
|
| 54 |
Comparative biotransformation and mass-balance of [14C] BMS-986205, an inhibitor of IDO1, after oral administration to rats, dogs and humans
|
Liu-kreyche, Peggy
|
|
2019
|
34 |
1S |
p. S59
|
artikel
|
| 55 |
Comparative changes in renal gene expressions in chronic kidney disease and vitamin D deficient mouse models
|
Noh, Keumhan
|
|
2019
|
34 |
1S |
p. S18
|
artikel
|
| 56 |
Comprehensive hepatocellular disposition profiling of parent compound and its major metabolites in sandwich-cultured PXB-cells by D-PREX
|
Kanda, Katsuhiro
|
|
2019
|
34 |
1S |
p. S53-S54
|
artikel
|
| 57 |
Considerations from the IQ Induction working group in response to drug-drug interaction guidances from regulatory agencies
|
Hariparsad, Niresh
|
|
2019
|
34 |
1S |
p. S11
|
artikel
|
| 58 |
Contribution of hepatic FMO-1 in the metabolism of compound 1. Implication of clearance mechanism and extrapolation of metabolism data from preclinical species to humans
|
Bowlin, Steve
|
|
2019
|
34 |
1S |
p. S30
|
artikel
|
| 59 |
Contribution of UGT1A1, CYP2A6, CYP2C9, and CYP3A4 in metabolism of belinostat
|
Luo, Gang
|
|
2019
|
34 |
1S |
p. S59
|
artikel
|
| 60 |
Cope elimination mediated by human FMO1 leads to formation of reactive Michael Acceptor intermediate
|
Lai, Weidong
|
|
2019
|
34 |
1S |
p. S58
|
artikel
|
| 61 |
Covalent binding – from 20th century liability to 21st century targeted therapies
|
Slatter, Greg
|
|
2019
|
34 |
1S |
p. S14
|
artikel
|
| 62 |
Covalent binding of trimethoprim: Implications for trimethoprim-induced adverse reactions
|
Cao, Yanshan
|
|
2019
|
34 |
1S |
p. S20
|
artikel
|
| 63 |
Cryopreserved human intestinal mucosa: a novel in vitro 3-D Organ culture for the evaluation of P450 Induction in human intestines
|
Li, Albert P.
|
|
2019
|
34 |
1S |
p. S43
|
artikel
|
| 64 |
Cryopreserved human intestinal mucosa as a 3-Dimensional organoid culture for the evaluation of inestinal drug metabolism, drug-drug interactions, enterotoxicity, and enteropharmacology
|
Li, Albert P.
|
|
2019
|
34 |
1S |
p. S46
|
artikel
|
| 65 |
Cytochrome P450 3A enzyme-dependent thalidomide toxicity and inducibility in cultured human placental cells
|
Murayama, Norie
|
|
2019
|
34 |
1S |
p. S27
|
artikel
|
| 66 |
Cytotoxicity in primary human hepatocytes exposed to various microcystin congeners
|
Richardson, Vicki
|
|
2019
|
34 |
1S |
p. S50
|
artikel
|
| 67 |
Deep convolution neural netwroks analysis of chemical images: Applications in drug discovery and development
|
Koneti, Geervani
|
|
2019
|
34 |
1S |
p. S35-S36
|
artikel
|
| 68 |
DESI-MS imaging to observe the drug and drug-induced events in tumor tissue
|
Kim, Sang Kyoon
|
|
2019
|
34 |
1S |
p. S34-S35
|
artikel
|
| 69 |
Determining levels of methylenedianiline and toluenediamine as biomarkers for isocyanate exposure in human urine by UPLC-MS/MS
|
Lépine, Maggy
|
|
2019
|
34 |
1S |
p. S21-S22
|
artikel
|
| 70 |
Developing peptides therapeutics by understanding their metabolism and trafficking
|
Cancilla, Mark
|
|
2019
|
34 |
1S |
p. S13
|
artikel
|
| 71 |
Developmental immunotoxicity
|
Collinge, Mark
|
|
2019
|
34 |
1S |
p. S4
|
artikel
|
| 72 |
Development and validation of an LC-MS/MS method for vesicle assay using corning® Transportocells™ HEK293-derived ABC transporter membrane vesicles BCRP and MRP2
|
Cooper, Kirsten
|
|
2019
|
34 |
1S |
p. S72
|
artikel
|
| 73 |
Development of a discovery CYP Inhibition screen for early identification of DDI Liabilities
|
Sierra, Teresa
|
|
2019
|
34 |
1S |
p. S38
|
artikel
|
| 74 |
Development of a novel orally active inverse agonist of estrogen-related receptor gamma (ERRγ), KH-NDTC as an enhancer for sodium iodide symporter: Its pharmacological effects in anaplastic thyroid cancer (ATC) in vitro and in vivo
|
Jeon, Yong Hyun
|
|
2019
|
34 |
1S |
p. S34
|
artikel
|
| 75 |
Development of a novel predictive in vitro non human primate proximal tubule model for drug transporter and nephrotoxicity studies
|
Brown, Colin
|
|
2019
|
34 |
1S |
p. S53
|
artikel
|
| 76 |
Development of a quantitative bioanalytical method for the assessment of benserazide in pre-clinical samples
|
Wang, Amy Q.
|
|
2019
|
34 |
1S |
p. S38
|
artikel
|
| 77 |
Development of endogenous biomarkers for CYP3A to be used in drug interaction studies
|
Andersson, Tommy
|
|
2019
|
34 |
1S |
p. S11-S12
|
artikel
|
| 78 |
Development of UGT1A7 and UGT1A8 Inhibition assays using recombinant enzymes as a test system
|
Singh, Ritu
|
|
2019
|
34 |
1S |
p. S45
|
artikel
|
| 79 |
Different measures of varenicline adherence, nicotine metabolite ratio and smoking abstinence
|
Peng, Annie R.
|
|
2019
|
34 |
1S |
p. S16-S17
|
artikel
|
| 80 |
Disentangling host and microbiome contributions to drug pharmacokinetics and toxicity
|
Goodman, Andrew
|
|
2019
|
34 |
1S |
p. S11
|
artikel
|
| 81 |
Distribution and excretion of a new oral formulation of docetaxel in mice
|
Kim, Byoung Soo
|
|
2019
|
34 |
1S |
p. S31
|
artikel
|
| 82 |
Distribution and pharmacokinetics of 3H-Gemcitabine after single and multiple intraperitoneal treatment alone and in combination with intravenous docetaxel in BXPC-3 tumor bearing mice
|
Spencer, Elizabeth
|
|
2019
|
34 |
1S |
p. S32
|
artikel
|
| 83 |
Does plasma membrane and total transporter abundance differ between suspended, plated, sandwich culture hepatocytes and human liver tissue?
|
Kumar, Vineet
|
|
2019
|
34 |
1S |
p. S17
|
artikel
|
| 84 |
Drug-microbe interactions in HIV transmission
|
Klatt, Nichole
|
|
2019
|
34 |
1S |
p. S10-S11
|
artikel
|
| 85 |
Drug target quantitation, translational PK/PD
|
Palandra, Joe
|
|
2019
|
34 |
1S |
p. S13
|
artikel
|
| 86 |
Dysregulation of transporters in maternal disease; potential impact on fetal drug exposure
|
Piquette-Miller, Micheline
|
|
2019
|
34 |
1S |
p. S7
|
artikel
|
| 87 |
Effective inhibition of CYP3A4-Dependent drug oxidation by anti-CYP3A4 Antibodies in metmax cryopreserved human hepatocytes
|
Li, Albert P.
|
|
2019
|
34 |
1S |
p. S49
|
artikel
|
| 88 |
Effect of age on brain exposure of P-GP substrates in neonatal rats
|
Rooney, Michael
|
|
2019
|
34 |
1S |
p. S31
|
artikel
|
| 89 |
Effect of renal transplantation on organochlorine pesticide (OCPS) Levels in chronic kidney disease patients (CKD-5D): A Longitudinal study
|
Himani, Amit Kumar
|
|
2019
|
34 |
1S |
p. S64
|
artikel
|
| 90 |
Effects of essential oils of culinary herbs and spices on the CYP3A4 Expression in primary human hepatocytes and cell lines
|
Bartonkova, Iveta
|
|
2019
|
34 |
1S |
p. S39-S40
|
artikel
|
| 91 |
Effects of mycophenolic acid and clinical variables on tacrolimus exposure in de novo, steroid-free adult renal transplant patients
|
Kiang, Tony KL.
|
|
2019
|
34 |
1S |
p. S66
|
artikel
|
| 92 |
Effects of PEG200 and PEG400 on human renal uptake/efflux transporters
|
Houle, Robert
|
|
2019
|
34 |
1S |
p. S72
|
artikel
|
| 93 |
Effects of thyroparathyroidectomy on clinical pathology and bone density in the rat
|
Poulin, Dominic
|
|
2019
|
34 |
1S |
p. S37-S38
|
artikel
|
| 94 |
Elimination of [14C] LY3023414 by aldehyde oxidase and CYP enzymes in humans following oral administration
|
Zhou, Lian
|
|
2019
|
34 |
1S |
p. S63
|
artikel
|
| 95 |
Endogenous biomarkers for drug metabolism and transporter activity
|
Giacomini, Kathy
|
|
2019
|
34 |
1S |
p. S12
|
artikel
|
| 96 |
Enhanced metabolite identification using orbitrap tribrid mass spectrometer
|
Comstock, Kate
|
|
2019
|
34 |
1S |
p. S32-S33
|
artikel
|
| 97 |
Environmental xenobiotics safety assessment through comparative metabolism study in fish, swine, goat, chicken, rat and human
|
Ma, Mingming
|
|
2019
|
34 |
1S |
p. S30
|
artikel
|
| 98 |
Equilibrative nucleoside transporter 1 (ENT1) facilitates transfer of the antiretroviral drug abacavir across the placenta
|
Cerveny, Lukas
|
|
2019
|
34 |
1S |
p. S71-S72
|
artikel
|
| 99 |
Established chemical knockout condition for P-GP mediated efflux at the blood-brain-barrier in cynomolgus monkey
|
Nakakariya, Masanori
|
|
2019
|
34 |
1S |
p. S76
|
artikel
|
| 100 |
Establishment of albumin-deficient NOG mice as a useful model for drug discovery research
|
Suemizu, Hiroshi
|
|
2019
|
34 |
1S |
p. S20
|
artikel
|
| 101 |
Estimating efflux transporter-mediated disposition using transporter gene knockout rats
|
Miyake, Taiji
|
|
2019
|
34 |
1S |
p. S21
|
artikel
|
| 102 |
Evaluation of a pre-constructed relative induction score (RIS) curve for prediction of CYP3A4 induction response in vivo
|
Zhang, George
|
|
2019
|
34 |
1S |
p. S44-S45
|
artikel
|
| 103 |
Evaluation of the time-course of CYP Induction and impact on drug interaction risk assessment from the IQ Induction working group
|
Hariparsad, Niresh
|
|
2019
|
34 |
1S |
p. S40
|
artikel
|
| 104 |
Expanded primary human liver sinusoidal endothelial cells as a predictive tool in hepatotoxicity evaluation
|
Noerenberg, Astrid
|
|
2019
|
34 |
1S |
p. S51
|
artikel
|
| 105 |
Experimental approaches to understand intracellular based drug bioavailability
|
Artursson, Per
|
|
2019
|
34 |
1S |
p. S3
|
artikel
|
| 106 |
Expression and induction ability of cytochrome P450 in human hepatocytes isolated from chimeric mice with humanized livers
|
Uehara, Shotaro
|
|
2019
|
34 |
1S |
p. S44
|
artikel
|
| 107 |
Expression of concentrative nucleoside transporters (SLC28A) in the human placenta; effects of gestation age and prototype differentiation-affecting agents
|
Jiraskova, Lucie
|
|
2019
|
34 |
1S |
p. S73
|
artikel
|
| 108 |
Ex vivo whole liver perfusion model for prediction of drug-drug interactions and biliary excretion of rosuvastatin
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van de Steeg, Evita
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2019
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34 |
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p. S48
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artikel
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Factors that influence tranexamic acid overdose in cardiac surgical patients with chronic renal dysfunction
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Yang, Qi
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2019
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34 |
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p. S68
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artikel
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| 110 |
Future perspectives related to hepatic enzyme induction
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LeCluyse, Edward
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2019
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34 |
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p. S11
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artikel
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| 111 |
Generation of reproducible predictive models using parallelized modified teaching learning based search optimization method and its applications in drug discovery and development
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Koneti, Geervani
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2019
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34 |
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p. S36
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artikel
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Genetic predictors and underlying mechanism of treatment-related complications in childhood acute lymphoblastic leukemia
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Krajinovic, Maja
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2019
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34 |
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p. S8
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artikel
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Genome-guided medications for safer and more effective treatment of disease
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Ross, Colin
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2019
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34 |
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p. S8
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artikel
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Genotype-sensitive reversible and time-dependent CYP2D6 Inhibition in human liver microsomes
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Storelli, Flavia
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2019
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34 |
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p. S41-S42
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artikel
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Hepatic 3D spheroids: an in vitro tool for studying hepatic function and drug toxicity
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Lahiri, Sujoy
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2019
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34 |
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p. S49
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artikel
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Hepatobiliary transporter expression and functional uptake of substrates in 2D sandwich cultures using upcyte® hepatocytes
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Noerenberg, Astrid
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2019
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34 |
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p. S76
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artikel
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High-throughput kidney proximal tubules-on-a-chip for predictive renal toxicity screening
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Saleh, Anthony
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2019
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34 |
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p. S55
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artikel
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| 118 |
High-Throughput Liver-ON-A-Chip for predictive hepatotoxicity screening
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Saleh, Anthony
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2019
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34 |
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p. S50
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artikel
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High-throughput, perfused intestinal tubules for real-time assessment of drug-induced barrier disruption
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Lowman, John
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2019
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34 |
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p. S54
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artikel
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| 120 |
How to be selectively promiscuous
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Taunton, Jack
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2019
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34 |
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p. S14
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artikel
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Human amyloid-beta 1-40 disposition after intravenous and intracerebral injections in the rat
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Peng, Hao Benson
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2019
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34 |
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p. S65
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artikel
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| 122 |
Human ex vivo model to study intestinal processes and microbiome induced metabolism
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Stevens, Lianne
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2019
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34 |
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p. S55-S56
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artikel
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Identification of dopa-modified amino acids using high-resolution tandem mass spectrometry
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Sansoucy, Maxime
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2019
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34 |
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p. S25
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artikel
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| 124 |
Identification of metabolomic biomarkers for endometrial cancer and its recurrence after surgery in postmenopausal women
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Audet-Delage, Yannick
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2019
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34 |
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p. S29-S30
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artikel
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Immunological components of liver injury
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Ju, Cynthia
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2019
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34 |
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p. S4
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artikel
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| 126 |
Immuno oncology state-of-the-field and how it helps understand the immune system and mechanisms for drug efficacy and toxicity
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Hollenbaugh, Diane
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2019
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34 |
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p. S5
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artikel
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Impact of hepatic drug distribution on predictions of clearance
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Sodhi, Jasleen K.
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2019
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34 |
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p. S23
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artikel
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| 128 |
Influence of dichloroacetate treatment on the contributions of rodent brain, heart, liver and kidney in the activity of GSTZ1
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Squirewell, Edwin
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2019
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34 |
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p. S46-S47
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artikel
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Inhibition of lithocholic ACID 3-Oxidation by selective estrogen receptor modulators
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Bansal, Sumit
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2019
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34 |
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p. S45
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artikel
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| 130 |
Inhibition of solute carrier (SLC) transporter proteins using corning® transportocells™ for DDI assessment
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Webber, Guy
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2019
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34 |
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p. S78
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artikel
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| 131 |
Inhibition of UGT enzymes using recombinant UGT Enzymes for DDI Assessment
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Webber, Guy
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2019
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34 |
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p. S45-S46
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artikel
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In silico approaches to modeling transporter data
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Varma, Manthena
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2019
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34 |
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p. S3
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artikel
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| 133 |
IN-SILICO Tool to predict new CYP3A5 Silensomestm using T-5 Substrate and lapatinib as mechanism-based inhibitor
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Martin, Solenne
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2019
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34 |
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p. S26
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artikel
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Integrating pharmacokinetic-pharmacodynamic modeling in preclinical assessment of mutant selective EGFR covalent tyrosine kinase inhibitor EGF816
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Li, Chun
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2019
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34 |
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p. S68
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artikel
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| 135 |
Interactions of herbal slimming agents with CYP Substrates: an in vitro study using human liver microsomes
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Nanjappan, Satheeshkumar
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2019
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34 |
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p. S55
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artikel
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| 136 |
Interindividual variability in hepatic expression of human sulfotransferase 2A1: Absolute quantification by LC-MS/MS proteomics and effect of ethnicity, genotype, age and gender
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Ladumor, Mayurbhai Kathadbhai
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2019
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34 |
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p. S16
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artikel
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Intestinal absorption and rodent brain exposure estimated by low efflux cells
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Pietrasiewicz, Alicia
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2019
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34 |
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p. S55
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artikel
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| 138 |
Intracellular drug concentrations: Theory, practice, and promise
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Smith, Dennis
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2019
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34 |
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p. S5
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artikel
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Intra-tissue catabolite characterization is a missing link in discovery of ADCs
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Zhang, Donglu
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2019
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34 |
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p. S9
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artikel
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Introduction to the fundamentals of induction
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Sinz, Michael
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2019
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34 |
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p. S2
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artikel
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Investigating acetaminophen covalent protein binding to glutathione S-transferases by LC-MS/MS
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Geib, Timon
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2019
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34 |
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p. S53
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artikel
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Investigation of human organic anion transporting polypeptide 2B1 using fluorescent anions
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Kawasaki, Tatsuya
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2019
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34 |
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p. S73-S74
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artikel
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| 143 |
In vitro and in vivo catabolism of TAK-164, a gcc-targeted antibody-drug conjugate
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Bolleddula, Jayaprakasam
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2019
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34 |
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p. S20-S21
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artikel
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In vitro and in vivo mechanisms of ADC disposition and activity
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Phipps, Colin
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2019
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34 |
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p. S9
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artikel
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| 145 |
In vitro assessment of the relative toxicity of a series of pyrrolizidine alkaloids: Taking account of metabolic activation and toxicokinetics
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Obringer, Cindy
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2019
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34 |
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p. S54
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In vitro characterization of ertugliflozin glucuronidation
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Lapham, Kimberly
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2019
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34 |
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p. S24
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artikel
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In vitro data fitting and interpretation
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Kenny, Jane
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2019
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34 |
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p. S2
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artikel
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| 148 |
In vitro-in vivo correlation of clearance for H3B-5942, a novel selective erα covalent antagonist (SERCA)
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Colombo, Federico
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2019
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34 |
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p. S22
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artikel
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In vitro metabolic and transporter profiling for maribavir (SHP620)
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Welty, Devin
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2019
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34 |
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p. S61
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artikel
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In vitro primary human hepatocyte 3D spheroid model for hepatotoxicity studies
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Li, Feng
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2019
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34 |
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p. S36
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artikel
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In vitro to in vivo extrapolation of intrinsic clearance for low turnover compounds using plated pooled donor human hepatocyte co-culture systems
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Kazmi, Faraz
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2019
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34 |
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p. S52
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artikel
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Keyword Index
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2019
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34 |
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p. VII-VIII
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Kidney transporters and nephrotoxicity
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Masereeuw, Rosalinde
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2019
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34 |
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p. S5
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artikel
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| 154 |
Lack of pharmacokinetic interaction between single oral doses of letermovir (MK-8228) and fluconazole in healthy subjects
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Adedoyin, Adedayo
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2019
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34 |
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p. S39
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artikel
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Lamisil (terbinafine): determining bioactivation pathways using computational modeling and experimental approaches
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Barnette, Dustyn
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2019
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34 |
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p. S57
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artikel
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LC-MS/MS Rapid identification of a novel tracer for a subtype specific phosphodiesterase (PDE) with no known ligand
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Chen, Jie
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2019
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34 |
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p. S67
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artikel
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Lignan enterolactone modulates cellular lipid and cholesterol homeostasis linking diverse molecular mechanisms
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De Silva, Franklyn
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2019
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34 |
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p. S33
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artikel
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Linked organs-on-chips for probing xenobiotic bioactivation, transport and toxicity
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Kelly, Edward J.
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2019
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34 |
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p. S9-S10
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LST-3TM12 is a member of the OATP1B-family and a functional transporter influenced by genetic variants
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Meyer zu Schwabedissen, Henriette
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2019
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34 |
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p. S75
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artikel
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LST-3TM12 is part of the FXR modulated gene network in hepatocytes
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Malagnino, Vanessa
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2019
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34 |
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p. S74-S75
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artikel
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Mechanistic modeling of in vitro assays to improve in vitro/in vivo extrapolation
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Fraczkiewicz, Grazyna
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2019
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34 |
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p. S3
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artikel
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Metabolism of 3,7-dihydroxyflavone mediated by cytochrome P450
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Bojic, Mirza
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2019
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34 |
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p. S25
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artikel
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Metabolism of pevonedistat in patients with advanced solid tumors after intravenous infusion of [14C] pevonedistat
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Chen, Hao
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2019
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34 |
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p. S57
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artikel
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Metabolite profiling using dried blood spot
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Katyayan, Kishore
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2019
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34 |
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p. S58
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artikel
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Method development for the solubilization of biological matrices
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Webber, Guy
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2019
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34 |
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p. S56
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artikel
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Methylindoles and methoxyindoles are agonists and antagonists of human aryl hydrocarbon receptor AhR
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Dvorak, Zdenek
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2019
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34 |
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p. S41
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artikel
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Metmax human hepatocyte/HEK293 Cytotoxicity assay for the evaluation of metabolism dependent drug toxicity and identification of drug candidates forming cytotoxic reactive metabolites
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Li, Albert P.
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2019
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34 |
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p. S49-S50
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artikel
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Microphysiological systems in pharma: Evolving a paradigm
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Proctor, William
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2019
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p. S10
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Microsomal cytochrome P450 enzyme activities in nonalcoholic steatohepatitis livers
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Czerwinski, Maciej
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2019
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34 |
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p. S25
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MRP4 (ABCC4) is a determinant of observed capecitabine and its metabolite concentrations during cancer therapy
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Almousa, Ahmed A.
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2019
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p. S64
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Mutations of flavin-containing monooxygenase 3 (FMO3) gene in Japanese cohorts
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Shimizu, Makiko
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2019
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34 |
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p. S63
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N-acetylation capacity of N-acetyltransferase 2 in human peripheral blood mononuclear cells regulated by NAT2 genotype and sirtuin 1
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Salazar-Gonzalez, Raul A.
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2019
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p. S17
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Nonclinical immunotoxicity testing assessment
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Wheeler, Jennifer
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2019
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34 |
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p. S4-S5
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Novel insights into predicting hepatic DDI liabilities when transporters and enzymes are involved
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Patilea-Vrana, Gabriela
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2019
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p. S15
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Novel in vitro models to study transporters
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Lai, Yurong
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2019
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34 |
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p. S1
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Novel synthetic and computational approaches to the discovery of drugs targeting nonalcoholic fatty liver disease
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Westlin, William
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2019
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p. S6-S7
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On-target related immunotoxicity
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Lee, Dong
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2019
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p. S4
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Opportunities and challenges in the discovery of novel agents for the treatment of malaria
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Burrows, Jeremy
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2019
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p. S12-S13
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Optimization of stepped collision energies of hcd in orbitrap mass spectrometry for metabolite structure elucidation
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Zhao, Jianwei
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2019
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p. S38-S39
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artikel
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Oxidative metabolism of synthetic cannabinoid STS-135 by recombinant P450S and human liver microsomes
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Yarbrough, Azure
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2019
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34 |
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p. S28
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artikel
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PBPK modeling of induction
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Zhao, Ping
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2019
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34 |
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p. S11
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artikel
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Pegylated crushed gold shell-radiolabeled core nanoballs for in vivo tumor imaging with dual positron emission tomography and cerenkov luminescent imaging
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Jeon, Yong Hyun
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2019
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p. S47
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Pet imaging to understand hepatobiliary transporters
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Sugiyama, Yuichi
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2019
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34 |
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p. S1
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Pharmacogenomics in drug response and safety assessment
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Daly, Ann
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2019
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p. S6
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Pharmacokinetic changes in pregnancy: Clinical implications
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Ito, Shinya
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2019
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p. S7
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Phosphorylated nuclear receptors as drug-targets
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Negishi, Masahiko
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2019
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p. S2
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Physiologically based pharmacokinetic model predictions of ivosidenib (AG-120) as a victim and perpetrator of drug–drug interactions
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Prakash, Chandra
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2019
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p. S70
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Polymorphisms in canine glutathione S-Transferase (GST) genes: Prevalence and functional relevance
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Sacco, James
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2019
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p. S24
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Population pharmacokinetics of immediate-release tacrolimus in steroid-free adult renal transplant recipients
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Rong, Yan
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2019
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p. S66
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Potential exposure to DI-2-Ethylhexyl terephthalate and DINCH, two phthalate replacements, in American adults
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Silva, Manori
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2019
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p. S60-S61
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artikel
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Preclinial biopharmaceutics and pharmacokinetic characterization of an HIV-1 Replication inhibitor DB213
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Zuo, Zhong
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2019
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34 |
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p. S39
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artikel
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Preclinical development of the PI3K Alpha selective and PIK3CA Mutant selective inhibitor GDC-0077 and prediction of its human pharmacokinetics
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Pang, Jodie
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2019
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p. S37
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Predicting and preventing the inactivation of drugs by human gut bacteria
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Turnbaugh, Peter
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2019
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p. S10
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Predicting and verifying maternal-fetal exposure to drugs during pregnancy
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Unadkat, Jashvant
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2019
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p. S7
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Prediction of adverse drug reactions of biased data using bootstrap aggregating and machine learning techniques
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Ghosh, Dipayan
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2019
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p. S33-S34
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Prediction of human hepatic clearance for cytochrome P450 substrates via a new culture method using the collagen vitrigel membrane chamber and PXB-cells
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Watari, Ryuji
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2019
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34 |
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p. S23
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artikel
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Prediction of human-specific metabolites of mianserin, cyproheptadine, and carbazeran using chimeric mice with humanized liver (PXB-MICE)
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Kato, Suguru
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2019
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p. S58
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Prediction of respiratory toxicity using chemical information and machine learning techniques
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Ghosh, Dipayan
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2019
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p. S34
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Predictive performance of Simcyp default models of 8 cytochrome P450 modulators in different clinical senarios
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Samer, Caroline
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2019
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p. S69
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Probe drugs for clinical transporter DDI Evaluation
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Zamek-Gliszczynski, Maciej J.
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2019
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p. S1
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Profiling of flavored non-alcoholic beverages toward trancriptional activity of PPAR gamma using a novel reporter cell line PAZ-PPARG
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Illes, Peter
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2019
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p. S63-S64
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Qualification and application of an in vitro liver model early in pharmaceutical development to help derisk drug-induced liver injury (DILI)
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Mitra, Kaushik
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2019
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p. S42
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Quality-by-design (QBD) approach to address rigor and reproducibility in dmet quantitative proteomics
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Prasad, Bhagwat
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2019
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p. S70
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Quantitation of plasma membrane drug transporters enables bottom-up PBPK modeling of transporter substrates
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Kikuchi, Ryota
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2019
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p. S74
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Quantitative determination of the effect of DDT and DDE treatments on CYP1 enzyme expression in MCF-7 Cells
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Raccor, Brianne
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2019
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p. S27-S28
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Quantitative investigation of OATP1B-mediated drug-drug interactions using endogenous substrates
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Kusuhara, Hiroyuki
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2019
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p. S12
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Quantitative mass balance, tissue distribution, pharmacokinetics and biotransformation pathway of praliciguat, a clinical-stage sgc stimulator, after oral administration in rats
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Banijamali, Ali
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2019
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p. S56-S57
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Quantitative prediction of CYP3A4 Induction using simple relative factor approach
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Kuramoto, Shino
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2019
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p. S42-S43
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Quantitative prediction of drug interaction potential between cobicistat and ruzasvir using a physiological based pharmacokinetic modeling approach
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Wang, Ying-Hong
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2019
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p. S71
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Quantitative prediction of metabolite exposures in humans using chimeric mice with humanized-liver
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Watari, Ryosuke
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2019
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p. S61-S62
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Rapid ADME screening for streamlined FDA submission; a case study assessing oral absorption validation and transporter substrate assessment of new molecular entities in wt caco-2 cells (C2BBEI)
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Thomas, Kevin
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2019
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p. S21
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Rapid CYP450 quantification by immunoaffinity-mass spectrometry
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Pötz, Oliver
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2019
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p. S27
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Reactive metabolite formation by irreversible and quasi-irreversible cytochrome P450 Inhibitors
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Thomas, Jennifer
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2019
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p. S40-S41
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Recommendations for in vitro CYP3A4 mRNA data analysis for drug-drug interaction risk assessment from the IQ Induction working group
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Tweedie, Donald
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2019
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p. S44
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Reduced parent-metabolite(s) physiologically-based pharmacokinetic model: Application to mycophenolic acid
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Matsunaga, Norikazu
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2019
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p. S69
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Regulatory requirements to assess induction
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Berglund, Eva Gil
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2019
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p. S11
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Relative activity factor (RAF)-based scaling of uptake clearance of OATP1B substrates from transfected cell systems to human hepatocytes and to in vivo
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Izumi, Saki
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2019
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p. S19
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Resistance mediated by lysosomal sequestration of anticancer agents in vitro
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Mlejnek, Petr
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2019
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34 |
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p. S21
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artikel
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| 219 |
Revisiting evaluation of CYP2C9 and CYP2C19 Induction in vitro: potential for robust induction responses with ≥ 4-Day hepatocyte exposure times
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Stresser, David
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2019
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34 |
1S |
p. S43-S44
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artikel
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| 220 |
RPL28 Promoter polymorphism RS4806668 is associated with reduced survival in folfiri-treated metastatic colorectal cancer patients
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Labriet, Adrien
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2019
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34 |
1S |
p. S64-S65
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artikel
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| 221 |
Screening for phase I and phase II drug metabolism using supplemented liver and intestinal S9 fractions: A cocktail approach
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Thomas, Kevin
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2019
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34 |
1S |
p. S24-S25
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artikel
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| 222 |
Semi-physiologically based pharmacokinetic model allows prediction of CNS disposition of ONO-2333MS in humans
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Matsunaga, Norikazu
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2019
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34 |
1S |
p. S69-S70
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artikel
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| 223 |
Sequential metabolism kinetics of Δ9-Tetrahydrocannabinol (THC) and ITS Psychoactive 11-OH-THC Metabolite
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Patilea-Vrana, Gabriela
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2019
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34 |
1S |
p. S60
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artikel
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| 224 |
Sex differences in brain oxycodone metabolism and analgesia
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Arguelles, Nicole
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2019
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34 |
1S |
p. S29
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artikel
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| 225 |
Simultaneous assessment of transporter drug–drug interactions using a probe drug cocktail in cynomolgus monkey
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Varma, Manthena
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2019
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34 |
1S |
p. S77
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artikel
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| 226 |
Simultaneous measurements of N1-methylnicotinamide, creatinine, isobutyryl-L-carnitine by liquid chromatograph with high resolution mass spectrometry for assessing the activities of multiple renal cationic transporters in first-in-human clinical trial
|
Luo, Lina
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2019
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34 |
1S |
p. S74
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artikel
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| 227 |
Simultaneous modeling of metabolism, competitive and mechanism based inhibition
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Burt, Howard
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2019
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34 |
1S |
p. S3-S4
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artikel
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| 228 |
Site-specific deuterium substitution: A viable approach in drug discovery and development
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Bradbury, Margaret
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2019
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34 |
1S |
p. S8-S9
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artikel
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| 229 |
Steroidal anti-androgens inhibit lithocholic acid sulfonation and increase lithocholic acid-induced toxicity in a human hepatocellular carcinoma cell model
|
Wong, Siew Ying
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2019
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34 |
1S |
p. S18
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artikel
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| 230 |
Studying the metabolism of sunscreen compounds in vitro by LC-MS/MS
|
Guesmi, Amal
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2019
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34 |
1S |
p. S57-S58
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artikel
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| 231 |
Substrate-dependent interactions between natural flavonoids and drug transporter OATP2B1
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Nabekura, Tomohiro
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2019
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34 |
1S |
p. S75-S76
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artikel
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| 232 |
Systems pharmacokinetic modeling of ADCs
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Shah, Dhaval
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2019
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34 |
1S |
p. S9
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artikel
|
| 233 |
Tanshinone IIA reverses rifampicin-induced liver injury via activating NRF2-mediated regulation of human NTCP transporter expression
|
Yang, Yujie
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2019
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34 |
1S |
p. S78
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artikel
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| 234 |
Targeted covalent inhibitors for drug design
|
Baillie, Thomas
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2019
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34 |
1S |
p. S13-S14
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artikel
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| 235 |
Technical considerations for evaluating human liver enzyme induction potential
|
Ferguson, Stephen
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2019
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34 |
1S |
p. S2
|
artikel
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| 236 |
The combined application of long term hepatic co-culture and RNA interference for reaction phenotyping: lessons learned
|
Borel, Anthony
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2019
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34 |
1S |
p. S49
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artikel
|
| 237 |
The development of a CRISPR/Cas-mediated PD-1 knockout rat model to study idiosyncratic drug reactions including nevirapine-induced liver injury
|
Cho, Tiffany
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2019
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34 |
1S |
p. S15-S16
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artikel
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| 238 |
The hurdle of human PK Predictions for hepatic oatp substrates: lessons learned from rat allometry
|
Mei, Hong
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|
2019
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34 |
1S |
p. S67
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artikel
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| 239 |
The impact of plasma protein binding on the tissue distribution of warfarin - investigation in nagase analbuminemic rats (NAR)
|
Pang, Jodie
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2019
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34 |
1S |
p. S37
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artikel
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| 240 |
The phenotyping of solute carrier transporters in human primary hepatocytes
|
Bi, Yi-an
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2019
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34 |
1S |
p. S71
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artikel
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| 241 |
Therapeutic targeting of the pyruvate dehydrogenase complex/pyruvate dehydrogenase kinase (PDC/PDK) axis for congenital and acquired metabolic diseases
|
Stacpoole, Peter
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2019
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34 |
1S |
p. S61
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artikel
|
| 242 |
The role of nucleoside transporters in entecavir transport across placenta
|
Karbanova, Sara
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|
2019
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34 |
1S |
p. S40
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artikel
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| 243 |
The role of reductases in drug discovery and development
|
Di, Li
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2019
|
34 |
1S |
p. S62
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artikel
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| 244 |
The utility of liver spheroids in addressing current issues in drug metabolism and liver toxicity evaluations
|
Gan, Jinping
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|
2019
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34 |
1S |
p. S10
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artikel
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| 245 |
Tissue-specific mechanisms of irinotecan metabolism
|
Vrana, Marc
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2019
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34 |
1S |
p. S47
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artikel
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| 246 |
Title page
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|
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2019
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34 |
1S |
p. i
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artikel
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| 247 |
TOC
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|
|
2019
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34 |
1S |
p. ii-iv
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artikel
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| 248 |
Toxicogenomics and systems toxicology approaches to understanding adverse outcomes
|
Willy, Jeffrey
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|
2019
|
34 |
1S |
p. S8
|
artikel
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| 249 |
Transcriptomic biomarkers to assess the liver and metabolic responses associated with bioactivation mechanisms of drug induced liver injury
|
Monroe, James
|
|
2019
|
34 |
1S |
p. S36
|
artikel
|
| 250 |
Transporters and arsenic toxicity
|
Leslie, Elaine
|
|
2019
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34 |
1S |
p. S6
|
artikel
|
| 251 |
Transporters and drug-induced liver injury
|
Brouwer, Kim
|
|
2019
|
34 |
1S |
p. S5
|
artikel
|
| 252 |
Understanding DMPK of biotherapeutics using intact protein bioanalysis
|
Jian, Wenying
|
|
2019
|
34 |
1S |
p. S13
|
artikel
|
| 253 |
Understanding the translational capability of in vitro active hepatic OATP uptake data using PBPK modeling
|
Bowman, Christine
|
|
2019
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34 |
1S |
p. S47-S48
|
artikel
|
| 254 |
Unraveling the metabolic fate of potential therapeutic dimer compounds for Parkinson’s disease
|
Nwabufo, Chukwunonso
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|
2019
|
34 |
1S |
p. S59-S60
|
artikel
|
| 255 |
UP-regulation of ATP-binding cassette transporters in the placenta during PRE-eclampsia and the potential role of NRF2
|
Yu, Lu
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|
2019
|
34 |
1S |
p. S78
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artikel
|
| 256 |
Use of antiepileptics during pregnancy: Clinician’s view
|
Fantaneanu, Tadeu
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|
2019
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34 |
1S |
p. S7-S8
|
artikel
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| 257 |
Using electronic medical records to advance genomic medicine – novel approaches for finding actionable pharmacogenomics
|
Denny, Joshua
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|
2019
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34 |
1S |
p. S6
|
artikel
|
| 258 |
Using statistical analyses to demonstrate equivalency between automated and manual processes to deliver high quality in vitro adme data even faster
|
Amin, Jakal
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|
2019
|
34 |
1S |
p. S52
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artikel
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| 259 |
Utility and limitations of dual cholate shunt assay in preclinical species
|
More, Vijay
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|
2019
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34 |
1S |
p. S75
|
artikel
|
| 260 |
Virtual cell models to predict binding and distribution of chemicals in in vitro toxicity assays
|
Fisher, Ciarán
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|
2019
|
34 |
1S |
p. S4
|
artikel
|
| 261 |
Why is modelling of in vitro experimental data important?
|
Gardner, Iain
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|
2019
|
34 |
1S |
p. S2-S3
|
artikel
|
| 262 |
Zebrafish as a screening model for testing the permeability of blood-brain barrier to small molecules
|
Kim, Seong Soon
|
|
2019
|
34 |
1S |
p. S35
|
artikel
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